Folate conjugated trimethyl chitosan/graphene oxide nanocomplexes as potential carriers for drug and gene delivery

Hu, Huilan; Tang, Cui; Chen, Yin

doi:10.1016/j.matlet.2014.03.133

Cited by 58 publications

(11 citation statements)

References 15 publications

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“…several studies have modified the graphene derivatives by polymers such as polyethylenimine (PEI), [143][144][145][146] lactosylated chitosan oligosaccharide (LCO), chitosan (CS), [147][148][149] and polyamidoamine (PAMAM). 150,151 For instance, the results of Zhang's studies 113 clearly showed that the use of PEI-conjugated GO to deliver DOX and siRNA does not only lead to improved therapy efficiency but also to patient safety increment.…”

Section: Dovepressmentioning

confidence: 99%

<p>Applications of Graphene and Graphene Oxide in Smart Drug/Gene Delivery: Is the World Still Flat?</p>

Hoseini‐Ghahfarokhi¹,

Mirkiani²,

Mozaffari³

et al. 2020

IJN

154

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Graphene, a wonder material, has made far-reaching developments in many different fields such as materials science, electronics, condensed physics, quantum physics, energy systems, etc. Since its discovery in 2004, extensive studies have been done for understanding its physical and chemical properties. Owing to its unique characteristics, it has rapidly became a potential candidate for nano-bio researchers to explore its usage in biomedical applications. In the last decade, remarkable efforts have been devoted to investigating the biomedical utilization of graphene and graphene-based materials, especially in smart drug and gene delivery as well as cancer therapy. Inspired by a great number of successful graphene-based materials integrations into the biomedical area, here we summarize the most recent developments made about graphene applications in biomedicine. In this paper, we review the up-to-date advances of graphene-based materials in drug delivery applications, specifically targeted drug/ gene delivery, delivery of antitumor drugs, controlled and stimuli-responsive drug release, photodynamic therapy applications and optical imaging and theranostics, as well as investigating the future trends and succeeding challenges in this topic to provide an outlook for future researches.

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Section: Dovepressmentioning

confidence: 99%

<p>Applications of Graphene and Graphene Oxide in Smart Drug/Gene Delivery: Is the World Still Flat?</p>

Hoseini‐Ghahfarokhi¹,

Mirkiani²,

Mozaffari³

et al. 2020

IJN

154

View full text Add to dashboard Cite

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“…The loading capacity of DOX reached 30.9% and migration of pDNA could be completely retarded. The accumulative release of pDNA was 31.1% at 72 h. In vitro folate/trimethyl chitosan-modified GO at concentrations up to 80 mg L −1 after incubation for 48 h did not reduce the viability of HeLa cells [257].…”

Section: Gene Deliverymentioning

confidence: 99%

Nanocomposites as biomolecules delivery agents in nanomedicine

Bamburowicz-Klimkowska

Popławska

Grudziński

2019

J Nanobiotechnol

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Nanoparticles (NPs) are atomic clusters of crystalline or amorphous structure that possess unique physical and chemical properties associated with a size range of between 1 and 100 nm. Their nano-sized dimensions, which are in the same range as those of vital biomolecules, such as antibodies, membrane receptors, nucleic acids, and proteins, allow them to interact with different structures within living organisms. Because of these features, numerous nanoparticles are used in medicine as delivery agents for biomolecules. However, off-target drug delivery can cause serious side effects to normal tissues and organs. Considering this issue, it is essential to develop bioengineering strategies to significantly reduce systemic toxicity and improve therapeutic effect. In contrast to passive delivery, nanosystems enable to obtain enhanced therapeutic efficacy, decrease the possibility of drug resistance, and reduce side effects of “conventional” therapy in cancers. The present review provides an overview of the most recent (mostly last 3 years) achievements related to different biomolecules used to enable targeting capabilities of highly diverse nanoparticles. These include monoclonal antibodies, receptor-specific peptides or proteins, deoxyribonucleic acids, ribonucleic acids, [DNA/RNA] aptamers, and small molecules such as folates, and even vitamins or carbohydrates.

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“…The outcome of this research indicates that the carrier possesses high drug loading capacity and the drug was taken up by the cell through the mechanism of folate receptor mediated endocytosis 39 . Hu et al 40 industrialized a drug delivery system via conjugating the folate with trimethylchitosan (FTMC)/graphene oxide (GO) nanocomplexes (FGNCs) for the targeted delivery of DOX to the tumour cells. An insignificant cytotoxicity of FGNCs was observed in HeLa and A549 cells.…”

Section: Doxorubicinmentioning

confidence: 99%

“…The higher uptake level in HeLa cells with folate-receptor demonstrated the targeting capability of FGNCs. The efficiency of targeting delivery might decline the toxicity of the loaded anticancer therapeutic agent 40 . DOX was incorporated into the biodegradable succinyl chitosan nanoparticles functionalized with folic acid which were explained to be non-toxic in vitro.…”

Section: Doxorubicinmentioning

confidence: 99%

Folic Acid Decorated Chitosan Nanoparticles and its Derivatives for the Delivery of Drugs and Genes to Cancer Cells

et al. 2017

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Nanotechnology offers a number of nanoscale implements for medicine. Among these, nanoparticles are revolutionizing the field of drug and gene delivery. Chitosan is a natural polymer which provides a profitable tool to an innovative delivery system due to its inherent physicochemical and biological characteristics. Chitosan nanoparticles are promising drug and gene delivery carriers because of small size, better stability, low toxicity, inexpensiveness, simplicity, easy fabrication and versatile means of administration. Chitosan can also be easily modified chemically due to the presence of reactive functional hydroxide and amine groups. Folic acid is commonly engaged as a ligand, for targeting cancer cells, as its receptor, that transports folic acid into the cells through endocytosis and is over-expressed on the surface of several human epithelial cancer cells. Integrating folic acid into chitosan-based drug delivery inventions directs the systems with a well-organized targeting ability. The present review outlines several illustrations of this versatile system based on folate decorated chitosan, which have shown potential as auspicious delivery systems published over the past few years. In addition, it is probable to formulate chitosan nanocarriers that exhibit manifold usage beyond targeted delivery, such as nanotheranostics and cancer stem cell therapy.

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Folate conjugated trimethyl chitosan/graphene oxide nanocomplexes as potential carriers for drug and gene delivery

Cited by 58 publications

References 15 publications

<p>Applications of Graphene and Graphene Oxide in Smart Drug/Gene Delivery: Is the World Still Flat?</p>

<p>Applications of Graphene and Graphene Oxide in Smart Drug/Gene Delivery: Is the World Still Flat?</p>

Nanocomposites as biomolecules delivery agents in nanomedicine

Folic Acid Decorated Chitosan Nanoparticles and its Derivatives for the Delivery of Drugs and Genes to Cancer Cells

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