Folate-conjugated Fe3O4@SiO2@gold nanorods@mesoporous SiO2 hybrid nanomaterial: a theranostic agent for magnetic resonance imaging and photothermal therapy

Wang, Dawei; Zhu, Xiao; Lee, Siu Fung; Chan, George H.M.; Li, Hung‐Wing; Kong, Siu Kai; Yu, Jimmy C.; Chen, Cheng; Wáng, Yì Xiáng J.; Leung, Ken Cham‐Fai

doi:10.1039/c3tb20090f

Cited by 75 publications

(50 citation statements)

References 51 publications

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“…Cell viability was evaluated by MTT assay after 808 nm laser irradiation (10 W/cm 2 ) for 4 minutes (averaged from four experiments). #: p < 0.01 …”

Section: Gold‐iron Oxide Materialsmentioning

confidence: 93%

“…These observations render Au nanorods excellent candidates for light‐scattering imaging, photoacoustic imaging, and as photothermal therapeutic agents. We reported the layer‐by‐layer synthesis and characterization of a novel five‐component hybrid composite, Fe 3 O 4 @SiO 2 ‐Au nanorod@mesoSiO 2 ‐folic acid, which simultaneously processes magnetic and easily controllable optical properties in the near‐infrared region. Such a hybrid composite consisted of an Fe 3 O 4 @SiO 2 core, at which surfactant (cetyltrimethylammonium bromide, CTAB)‐coated Au nanorods [32a] were self‐assembled; then another thin mesoporous silica (mesoSiO 2 ) layer with amino groups was coated outside to render the system more stable.…”

Section: Gold‐iron Oxide Materialsmentioning

confidence: 99%

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Noble Metal-Iron Oxide Hybrid Nanomaterials: Emerging Applications

Leung

Xuan

2016

The Chemical Record

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This account provides an overview of current research activities that focus on the synthesis and applications of nanomaterials from noble metal (e.g., Au, Ag, Pd) and iron oxide (Fe3O4) hybrids. An introduction to the synthetic strategies that have been developed for generating M-Fe3O4 nanomaterials with different novel structures is presented. Surface functionalization and bioconjugation of these hybrid nanoparticles and nanocomposites are also reviewed. The utilization of the advantageous properties of both noble metals and iron oxide for a variety of applications, such as theranostics, gene delivery, biosensing, cell sorting, bioseparation, and catalysis, is discussed and highlighted. Finally, future trends and perspectives of these sophisticated nanocomposites are outlined. The fundamental requirements underpinning the effective preparation of M-Fex Oy hybrid nanomaterials shed light on the future development of heterogeneous catalysts, nanotheranostics, nanomedicines, and other chemical technologies.

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“…Cell viability was evaluated by MTT assay after 808 nm laser irradiation (10 W/cm 2 ) for 4 minutes (averaged from four experiments). #: p < 0.01 …”

Section: Gold‐iron Oxide Materialsmentioning

confidence: 93%

Section: Gold‐iron Oxide Materialsmentioning

confidence: 99%

Noble Metal-Iron Oxide Hybrid Nanomaterials: Emerging Applications

Leung

Xuan

2016

The Chemical Record

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“…[16] Thus, folic acid (FA), an onimmunogenic receptor-specific ligand, has been gradually used as as pecificm otif for targeting human cancer cells with overexpressed folate receptors. [17,18] For example, Lu et al prepared at argeting drug-delivery system by capping HMSNs with FA,w hich showed ah igh targeting efficacy toward KB cells (overexpressed folate receptors). [19] Chang et al reported that aP EG-and FA-coated tumor-targeted drug-delivery systema lso illustratedh igh cellular uptake efficiencyb yM CF-7 cells.…”

Section: Introductionmentioning

confidence: 99%

Shape‐Controlled Hollow Mesoporous Silica Nanoparticles with Multifunctional Capping for In Vitro Cancer Treatment

Geng

Chen

et al. 2017

Chemistry A European J

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A series of multifunctional shape-controlled nonspherical hollow mesoporous silica nanoparticles (HMSNs) drug carriers have been prepared by employing Fe O with four morphologies (capsule, cube, rice, and rhombus) as a sacrificial template and a multifunctional cap as the encapsulating shell. The resulting shape-controlled nonspherical HMSNs perfectly replicate the original morphology of the Fe O templates, which possess a high specific surface area, good monodispersity, perpendicular mesoporous channels, and excellent biocompatibility. After modification of polyethylene glycol (PEG) and folic acid (FA), the shape-controlled HMSN core and functional shell can then be integrated into a single device (HMSNs-PEG-FA) to provide an efficient and tumor-cell-selective drug-delivery system. The shape-controlled HMSNs and HMSNs-PEG-FA all show controlled pH-responsive release behavior for the anticancer drug doxorubicin hydrochloride (DOX). The in vitro results indicate that HMSNs-PEG-FA is biocompatible and selectively targets HeLa cells (overexpressed folate receptors). Fluorescence images show that desirable surface modification and the nonspherical shape effectively facilitate cellular internalization of HMSNs. It is expected that the construction of these unique nanomaterials with controlled morphology through the hard-templating technique may also provide useful information for the design of nanoscale multifunctional systems.

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“…Since the first discovery of M41S silica in 1992, mesoporous SiO 2 has become one of the most extensively studied materials due to its application in wide range of fields . Moreover, various techniques have been developed to control the pore structure, shape, and size of this material .…”

Section: Introductionmentioning

confidence: 99%

“…Since the first discovery of M41S silica in 1992, mesoporous SiO 2 has become one of the most extensively studied materials due to its application in wide range of fields. [26][27][28] Moreover, various techniques have been developed to control the pore structure, shape, and size of this material. [29][30][31] Many investigations have been devoted to mesoporous SiO 2 as supporting material for stabilizing TiO 2 nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Core@dual‐Shell Nanoporous SiO₂–TiO₂ Composite Fibers with High Flexibility and Its Photocatalytic Activity

Chen

Pan

et al. 2014

J. Am. Ceram. Soc.

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Structural design is of great importance to the performance of photocatalysts in environmental remediation. Therefore, micro/nanofibrous morphology and nanoporous local structures have been found to be beneficial to improve the photocatalytic activity. In this investigation, we report the design and fabrication of flexible and thermal stable nanoporous SiO2–TiO2 composite fibers as efficient photocatalysts. Combining electrospinning and modified Stöber techniques, core‐shell and mesoporous SiO2 fibers with high flexibility were fabricated and employed as the scaffold for supporting TiO2 nanoparticles. A nanoporous shell of TiO2 nanoparticles was then muffled over the SiO2 fibers to form core@dual‐shell SiO2–TiO2 composite fibers with hierarchically porous structure, which were conveniently patterned into a nonwoven, recyclable film. This nonwoven film exhibits better photocatalytic activity for Rhodamine B degradation under UV irradiation compared with some other TiO2‐based materials reported in recent years.

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Folate-conjugated Fe3O4@SiO2@gold nanorods@mesoporous SiO2 hybrid nanomaterial: a theranostic agent for magnetic resonance imaging and photothermal therapy

Cited by 75 publications

References 51 publications

Noble Metal-Iron Oxide Hybrid Nanomaterials: Emerging Applications

Noble Metal-Iron Oxide Hybrid Nanomaterials: Emerging Applications

Shape‐Controlled Hollow Mesoporous Silica Nanoparticles with Multifunctional Capping for In Vitro Cancer Treatment

Core@dual‐Shell Nanoporous SiO₂–TiO₂ Composite Fibers with High Flexibility and Its Photocatalytic Activity

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Folate-conjugated Fe3O4@SiO2@gold nanorods@mesoporous SiO2 hybrid nanomaterial: a theranostic agent for magnetic resonance imaging and photothermal therapy

Cited by 75 publications

References 51 publications

Noble Metal-Iron Oxide Hybrid Nanomaterials: Emerging Applications

Noble Metal-Iron Oxide Hybrid Nanomaterials: Emerging Applications

Shape‐Controlled Hollow Mesoporous Silica Nanoparticles with Multifunctional Capping for In Vitro Cancer Treatment

Core@dual‐Shell Nanoporous SiO2–TiO2 Composite Fibers with High Flexibility and Its Photocatalytic Activity

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Product

Resources

About

Core@dual‐Shell Nanoporous SiO₂–TiO₂ Composite Fibers with High Flexibility and Its Photocatalytic Activity