Folate and Vitamin B6 Rapidly Normalize Endothelial Dysfunction In Children With Type 1 Diabetes Mellitus

Abstract

High-dose folate and vitamin B6 normalized endothelial dysfunction in children with type 1 diabetes. This effect was maintained over 8 weeks, with no additional benefit from combination treatment.

Family history of hypertension increases risk of preeclampsia in pregnant women: a case-control study

“…(46) The third factor is the effect of folate in improving systemic endothelial function and therefore reducing the risk of such complications as preeclampsia. (47) There was a statistically significant relationship between advanced maternal age and preeclampsia in this study, which is in agreement with the results of previous studies. (15) Sexual partner change did not confer an increased risk of preeclampsia in this study.…”

Early Atherosclerosis Relates to Urinary Albumin Excretion and Cardiovascular Risk Factors in Adolescents With Type 1 Diabetes: Adolescent Type 1 Diabetes cardio-renal Intervention Trial (AdDIT)

“…The overweight epidemic has resulted in up to one-third of adolescents with type 1 diabetes in Australia being overweight or obese, consistent with international trends (24), and this could add to the cardiovascular burden of diabetes. BMI and waist circumference had direct relationships with IMT, but these did not remain on multivariate analysis of the cohort, 33% of whom were overweight or obese.…”

The Role of Complementary and Alternative Therapies in Pediatric Diabetes

“…23 The same study group compared folate and pyridoxamine supplementation in 124 children with type 1 diabetes. 24 In a similar randomized, double-blind, placebo-controlled study design, the investigators compared 4 groups: (1) folate 5 mg/d versus placebo; (2) pyridoxamine 100 mg/d versus placebo; (3) folate 5 mg/d and pyridoxamine 100 mg/d, and (4) 2 placebo tablets, with 30 subjects in each group. After 8 weeks of interventions, an improvement in FMD was noted in all 3 intervention groups, with no additional benefit from combination treatment.…”

“…Similar to the initial study, the beneficial effect was independent of HbA 1c and homocystine levels, and glucose and c-peptide. 24 Despite evidence that folate and pyridoxamine seem to improve short-term endothelial function in children with type 1 diabetes, larger studies with longer follow-up are needed. The effect sought is on endothelial function and not on HbA 1c .…”