Folate and Vitamin B12Metabolism in Weanling Rats Given a Maize Diet

Spector, I.; Metz, J.

doi:10.1093/ajcn/19.3.187

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1968

1975

Publication Types

Select...

Article4

Book1

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 8 publications

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

The relationships between vitamin B12 and folic acid and the effect of methionine on folate metabolism

1975

View full text Add to dashboard Cite

The relationship between vitamin B12 and folate and the effect of methionine on folate metabolism during B12 deficiency in rats is best explained by the prevention of the accumulation of 5-methyl-H4PteGlu by vitamin B12 and/or methionine. Although several points remain to be clarified, the 'methyl trap' hypothesis provides the most satisfactory explanation for the relation between vitamin B12, methionine and folic acid. This concept is extended by the hypothesis that H4PteGlu is the most active substrate for pteroylpolyglutamate synthetase, and thus accounts for the effect of methionine or vitamin B12 increasing liver folate levels.

show abstract