Folate and monoamine metabolism in epilepsy

5‐Hydroxyindoleacetic Acid and Homovanillic Acid in Cerebrospinal Fluid of Children with Febrile Convulsions

“…First, in the study of Habel et al (1981), some children received phenothiazines, antihistamines, or AEDs. The possible role of these medications on CSF monoamine metabolites is difficult to establish and has led to conflicting reports (Reynolds et al, 1975;Shaywitz et al, 1975;Chadwick et al, 1977; Kalfakis and Markianos, 1987). Second, the delay between the convulsion and the lumbar puncture was apparently more important in the study of Habel et al (1981) (within 2 8 h) than in the present study (mean time 2 h), which can lead to attenuation of the metabolite changes.…”

Effects of Change in Dietary Folic Acid Content on Pentylenetetrazol Seizure Threshold in Rat

“…However, until now decrease of brain folate levels by these drugs has not been reported in the literature and we ourselves were unable to induce it (unpublished results). Reynolds et al (1975) demonstrated a strong decrease in C S F folate content in treated epileptic patients.…”

“…The 5-methyl-THF content of basal ganglia and parts of the FA deficient NS NS NS brain stem is high (Korevaar et al, 1973). In a study of treated and untreated epileptic patients n = 16 n = 12 1264 165 1099 n = 7 1209 152 1056 Reynolds et al (1975) were able to demonstrate a negative correlation of folate levels and monoamine metabolites 5-HIAA and HVA in the CSF. The anticonvulsant effects of phenytoin and phenobarbital may then depend, in part, upon the interaction of t h e s e d r u g s with folate metabolism.…”

Depression in Patients With Epilepsy

“…Moreover, that there is a relationship between FA, monoamines and epilepsy has also been suggested (Chadwick et al 1975a;Reynolds et al 1975).…”

“…In conclusion, it seems that DA agonists can inhibit photosensitive generalised epilepsy and photomyoclonic responses both experimentally and clinically. 11yoclonus has been successfully treated with clonazepa.m (Chadwick et al 1975b) which has been shown to cause a rise in brain 5HT and 5HIAA in mice (Jenner et al 1975), and which leads to an increase of CSF 5HIAA in patients after treatment (Chadwick et al 1975b). In addition, the insecticide p,p'-DDT produces stimulus -sensitive intention myoclonus in humans and rodents (Garcin et al 1965;Chung Hwa....-1g and Van Woert 1978).…”