Folate and DNA Methylation

Crowell, Julie; Ly, Anna; Kim, Young–In

doi:10.1201/b10449-4

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Effects Of Folate Status On Dna Methylation In Animal Studies2

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2012

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“…In the colorectum, the majority of animal studies demonstrate a resistance to altered SAM and SAH levels and do not support an association between folate deficiency and genomic DNA methylation (31,85,86). However, a recent study reported that chronic, severe folate deficiency in older adult FIG.…”

Section: Effects Of Folate Status On Dna Methylation In Animal Studiesmentioning

confidence: 94%

“…The effect of folate deficiency and supplementation on DNA methylation in rodents has been previously reviewed (31,85,86). Briefly, it appears that prolonged and severe folate deficiency induces global DNA hypomethylation in the rodent liver (10,22), while moderate deficiency does not have a consistent effect.…”

Section: Effects Of Folate Status On Dna Methylation In Animal Studiesmentioning

confidence: 98%

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