Folate and Cancer Chemoprevention

Zhang, Shumin M.; Willett, Walter C.

doi:10.1007/978-1-59259-767-3_37

Cited by 3 publications

(5 citation statements)

References 162 publications

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“…Folate is an important constituent of vegetables and fruits. It functions as the coenzyme in the biosynthesis of thymidylate and purines (4)(5)(6). Insufficient folate status could increase DNA damage and instability by uracil misincorporation into DNA (5,7,8).…”

Section: Introductionmentioning

confidence: 99%

“…Insufficient folate status could increase DNA damage and instability by uracil misincorporation into DNA (5,7,8). Sufficient folate is also required to maintain an adequate cellular pool of S-adenosylmethionine, the universal methyl donor for DNA methylation (5,6,9). Folate deficiency may result in abnormal DNA methylation and uncontrolled gene expression leading to malignant transformation (5,8,10).…”

Section: Introductionmentioning

confidence: 99%

“…Folate deficiency may result in abnormal DNA methylation and uncontrolled gene expression leading to malignant transformation (5,8,10). Epidemiologic studies have suggested that diminished folate status increased the risk of cancer in various sites, including the stomach (6,(11)(12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

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Genetic Polymorphisms in Folate Metabolism and the Risk of Stomach Cancer

Zhang

Terry

Hou

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Folate deficiency has been implicated in the etiology of stomach cancer through abnormal DNA methylation and disrupted DNA synthesis and repair. Enzyme-coding genes involved in folate metabolism are often polymorphic. In a population-based study of 305 cases and 427 controls in Warsaw, Poland, we evaluated the risk of stomach cancer in relation to polymorphisms in folate-metabolizing genes, including MTHFR (Ex5+79C>T and Ex8À62A>C), MTR (Ex26À20A>G), and MTRR (Ex2À64A>G, Ex5+123C>T, Ex15+572C>T, Ex15À405A>T, Ex9À85C>T, Ex15À526G>A, and Ex14+14C>T). Polymorphisms in the MTHFR gene were not associated with stomach cancer risk. No notable effect was found for polymorphisms in MTR or MTRR either, although MTR Ex26À20 A>G and MTRR Ex5+123C>T polymorphisms were associated with a borderline increased risk of stomach cancer (MTR Ex26À20A>G, AG/GG versus AA: odds ratio, 1.35; 95% confidence interval, 0.96-1.90; MTRR Ex5+123C>T, CT/TT versus CC: odds ratio, 1.30; 95% confidence interval, 0.93-1.82). We did not find significant interactions between polymorphisms in MTHFR, MTR, and MTRR genes and dietary folate and alcohol consumption. Our study did not identify strong genetic determinants in the folate metabolism pathway for stomach cancer risk. (Cancer Epidemiol Biomarkers Prev 2007;16(1):115 -21)

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Genetic Polymorphisms in Folate Metabolism and the Risk of Stomach Cancer

Zhang

Terry

Hou

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…The turbulence generated by the irregular motion of the atmosphere influences the wavefront of the light waves, making it challenging for astronomical telescopes to achieve the ideal field of view and resolution (Zhang & Tao 2004;Guo et al 2022). In 1953, Babcock proposed the concept of adaptive optics (AO).…”

Section: Introductionmentioning

confidence: 99%

Breaking Boundaries: A Universal Wavefront Reconstruction Approach for High-resolution Solar Imaging

Ge,

Zhu,

Gao

et al. 2024

ApJL

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This Letter proposes a universal wavefront reconstruction approach based on a coupled data set and neural network, aiming to overcome the limitations of current algorithms in terms of universality and wavefront sensing accuracy for variable imaging objects. First, a novel data set, Multi-Object Wavefront Coupling Dataset (MOCD-Dataset), is developed to provide diverse data and enable the network to learn universal wavefront features. Next, a new universal wavefront reconstruction network called Object-Independent Wavefront Decoupling Network (OIWD-Net) is introduced, aiming to separate imaging object information from multiple variable images. Our algorithm eliminates the need for specialized wavefront sensors, has a simple system, high light energy utilization, and does not require customized models for each different type of imaging objects, making it highly practical. By combining the MOCD-Dataset and the OIWD-Net, excellent accuracy in wavefront reconstruction of different imaging objects has been achieved. This research provides a new solution for high-resolution image restoration in fields such as solar structure observation and astronomical high-resolution imaging.

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“…Hibiscus Rosa sinesis extract is a source of many potentially active constituents such as quercetin, glycosides, riboflavin, niacin, carotene, malvalic acid gentisic acid, margaric acid and lauric acid". [1][2][3][4][5][6]. Hibiscus flowers and leaves are used in India for the abortion, antifertility, contraceptive, Diuretic, Menorrhagia, Bronchitis, Emmengogue, emulcent, and Cough" [7].…”

Section: Introductionmentioning

confidence: 99%

Pharmacological Studies of Hibiscus Rosa Sinesis Leaf Extract

Agrawal

2023

AJARR

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We have undertaken to study the pharmacological activities of the hydro-methanolic leaves extract of Hibiscus rosa sinesis using standard screening methods such as disc diffusion and DPPH methods. In phytochemical screening, Secondary metabolites such as phenols, saponins, and tannins were present in. Hibiscus rosa sinesis leaf extract. The dose dependent antibacterial and antioxidant activities was also observed. The present study is important because Hibiscus Rosa sinensis plant is important in traditional medicine to cure various ailments.

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Folate and Cancer Chemoprevention

Cited by 3 publications

References 162 publications

Genetic Polymorphisms in Folate Metabolism and the Risk of Stomach Cancer

Genetic Polymorphisms in Folate Metabolism and the Risk of Stomach Cancer

Breaking Boundaries: A Universal Wavefront Reconstruction Approach for High-resolution Solar Imaging

Pharmacological Studies of Hibiscus Rosa Sinesis Leaf Extract

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