1971
DOI: 10.1136/jcp.s3-5.1.66
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Folate absorption

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Cited by 11 publications
(1 citation statement)
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“…Normal folate polyglutamate absorption in pernicious anaemia patients (Hoffbrand, 1971) suggests that cleavage of the peptide chain does not occur significantly in the gut lumen although the enzyme, whether derived from intestinal or pancreatic secretion or from desquamated intestinal cells, is available. ThepH in the gut rarely falls low enough to permit conjugase activity, and in pernicious anaemia in particular, is unlikely to fall much below neutrality.…”
Section: Discussionmentioning
confidence: 99%
“…Normal folate polyglutamate absorption in pernicious anaemia patients (Hoffbrand, 1971) suggests that cleavage of the peptide chain does not occur significantly in the gut lumen although the enzyme, whether derived from intestinal or pancreatic secretion or from desquamated intestinal cells, is available. ThepH in the gut rarely falls low enough to permit conjugase activity, and in pernicious anaemia in particular, is unlikely to fall much below neutrality.…”
Section: Discussionmentioning
confidence: 99%