FokI polymorphism in the vitamin D receptor gene in patients with hip osteoarthritis: A case-control study

Abstract

Objectives: This study aimed to examine whether there is an association between hip osteoarthritis and vitamin D receptor gene FokI polymorphisms. Patients and methods: In this case-control study, a total of 162 volunteers (43 males, 119 females; mean age: 62.4±9.3; range, 50 to 80 years) were included between March 2011 and March 2012. The patient group included 80 individuals with a diagnosis of coxarthrosis. Eightytwo individuals with normal hip, low back, and sacroiliac joint examination were included in the control group. The American College of Rheumatology hip osteoarthritis classification criteria were used in the diagnosis of coxarthrosis. Analysis of FokI polymorphisms was performed with restriction fragment length polymorphisms. Results: When the genotype and allele distributions of vitamin D receptor FokI polymorphisms were examined, no statistical difference was found in both groups. Conclusion: No significant association between the hip osteoarthritis and FokI polymorphisms could be obtained.

The Role of Vitamin C and Vitamin D in the Pathogenesis and Therapy of Periodontitis—Narrative Review

“…Naturally, VDRs come in polymorphism variants, making VitD supplementation quite a challenge. VDR variants come with different VitD bonding capacities, as shown in different studies [ 88 , 89 , 90 ]. VitD has an essential role in periodontitis, as a sufficient VitD level has beneficial effects on periodontitis prevalence and severity.…”