Foetal umbilical artery Doppler in small preterms: (<scp>IQ</scp>) Neurocognitive outcome at 5 years of age

Eger, Siw Helen W.; Sommerfelt, Kristian; Kiserud, Torvid; Markestad, Trond

doi:10.1111/apa.12164

Cited by 12 publications

(8 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Eleven studies reported outcomes in association with umbilical artery blood flow. Seven of these did not find an association between abnormal flow in the umbilical artery and neurocognitive outcome (Valcamonico et al, 2004, 2007; Kirsten et al, 2007; Leppänen et al, 2009; Shand et al, 2009; Torrance et al, 2010; Eger et al, 2013). Male fetuses with intrauterine growth restriction and absent or reversed end diastolic flow in the umbilical artery have performed worse on cognitive tests than those with appropriate growth for gestational age (Morsing et al, 2011).…”

Section: Resultsmentioning

confidence: 99%

Prenatal Risk Factors for Adverse Developmental Outcome in Preterm Infants—Systematic Review

et al. 2019

View full text Add to dashboard Cite

Background: Preterm infants are still at an increased risk for suboptimal neurodevelopmental outcomes when compared with term born infants. The development of a child born preterm can be jeopardized by suboptimal conditions during pregnancy, in addition to the suboptimal growth environment postnatally compared to the normal in utero environment. This review summarizes the literature on the role of chorioamnionitis, placental insufficiency, and maternal smoking on the developmental outcomes of preterm infants. Methods: A systematic database search was performed to identify all original articles published on or before September 12, 2018 that evaluated the impact of clinical or histological chorioamnionitis, abnormal prenatal fetal and placental blood flow, and prenatal smoking exposure on the neuropsychological and cognitive outcomes of preterm infants. We identified a total of 54 studies. Thirty five original articles evaluated the effects of clinical or histological chorioamnionitis; 15 studies evaluated the effects of abnormal blood flow patterns; and four studies evaluated the effects of maternal smoking during pregnancy. Results: The studies on prenatal risk factors showed conflicting results about the impact on the neurodevelopment of preterm infants. The majority of the studies did not show that chorioamnionitis poses a direct risk to the development of preterm infants. The role of abnormal prenatal placental and fetal blood flow on the development of preterm infants remained inconclusive because the sample sizes were often small and methodological problems complicated the interpretation of the data. Maternal smoking during pregnancy was assessed only in one cohort which showed that maternal smoking is a risk for suboptimal cognitive and neuropsychological development in preterm infants. Conclusions: This review summarizes the data on several prenatal risk factors which play a role in the developmental outcomes of preterm infants. To optimize the developmental outcomes, we need to first optimize the fetal wellbeing before birth. More research that extends from the fetal life to long-term developmental outcomes is needed.

show abstract

Section: Resultsmentioning

confidence: 99%

Prenatal Risk Factors for Adverse Developmental Outcome in Preterm Infants—Systematic Review

et al. 2019

View full text Add to dashboard Cite

show abstract

“…From an obstetric point of view, it is possible to postulate that the widespread use of Doppler sonography and other methods of evaluation of fetal well-being have contributed to define better timing of delivery of VLBW infants. 23,24 Among postnatal improvements, it is possible that better respiratory support, administration of surfactant, reduction of early neonatal sepsis and subsequent nosocomial infections, and improved nutritional support could have contributed to the increase in rates of normal neurodevelopmental outcome at 2 years as recorded in our series. 25,26 In conclusion, this study showed that in a homogenous population from a single institution, the increased survival of VLBW infants was mirrored by increased rates of normal neurodevelopmental outcome at 2 years.…”

Section: Discussionmentioning

confidence: 81%

“…In our analysis, in multivariate models, improved neonatal outcome over time was independent of antenatal steroid administration and mode of delivery, indicating that other factors play a crucial role in this trend. From an obstetric point of view, it is possible to postulate that the widespread use of Doppler sonography and other methods of evaluation of fetal well‐being have contributed to define better timing of delivery of VLBW infants …”

Section: Discussionmentioning

confidence: 99%

Obstetric risk factors and time trends of neurodevelopmental outcome at 2 years in very‐low‐birthweight infants: a single institution study

Gardella

Iacobone

Bogliolo

et al. 2015

Develop Med Child Neuro

View full text Add to dashboard Cite

ABBREVIATIONS pPROMPreterm premature rupture of membranes SGA Small for gestational age VLBW Very low birthweight AIM To assess the time trends of neonatal survival and infant neurodevelopmental outcome in very-low-birthweight children at 24 months corrected age over a 20-year period.METHOD The study cohort comprised 857 infants (439 males and 418 females) weighing less than 1500g at birth or delivered before 32 weeks gestational age in the period 1989 to 2008. Neurological examination and cognitive assessment of the infants (Bayley Scales of Infant Development and Griffiths Mental Developmental Scale) were performed at 24 months corrected age. RESULTSThe prevalence of neonatal survival with normal neurodevelopmental outcome increased from 55

show abstract

“…Among high-risk samples, UA Doppler predicts developmental delay [7][8][9][10] and motor development [9][10][11] at 1-2 years of age, while follow-up studies among 4-9-year-olds reported no association with intelligence quotient (IQ). [12][13][14] Among low-risk pregnancies, high UA-PI was associated with poorer memory functioning among 12-year-olds: differences in general reasoning or academic achievement, albeit in the same direction, were not statistically significant. 15 Evidence from large prospective population-based studies is lacking: while costly, the benefit of these studies is that they are ideally suited for This article is protected by copyright.…”

Section: Introductionmentioning

confidence: 87%

Fetal–placental blood flow and neurodevelopment in childhood: population‐based neuroimaging study

Sammallahti

Tiemeier

Louwen

et al. 2021

Ultrasound in Obstet & Gyne

View full text Add to dashboard Cite

Contribution:1. What are the novel findings of this work? Increased placental vascular resistance, measured using prenatal Doppler ultrasound, is associated with poorer motor and cognitive abilities among 4-12-year-old children. We used a populationbased sample of 2,803 mother-child dyads: this exceptional setting allowed us to investigate fetal determinants of neurodevelopment in a general population. What are the clinical implications of this work?Fetal-placental blood flow may impact long-term brain development. While these effects may be subtle at the population-level, future researchers should consider possible long-term effects when designing and evaluating early interventions.

show abstract

Foetal umbilical artery Doppler in small preterms: (IQ) Neurocognitive outcome at 5 years of age

Abstract: Absent or reversed end-diastolic flow in the umbilical artery (AREDF) was associated with increased risk of SCH in extremely preterm infants (GA <28 weeks).

Cited by 12 publications

References 32 publications

Prenatal Risk Factors for Adverse Developmental Outcome in Preterm Infants—Systematic Review

Prenatal Risk Factors for Adverse Developmental Outcome in Preterm Infants—Systematic Review

Obstetric risk factors and time trends of neurodevelopmental outcome at 2 years in very‐low‐birthweight infants: a single institution study

Fetal–placental blood flow and neurodevelopment in childhood: population‐based neuroimaging study

Contact Info

Product

Resources

About