Foetal Sulphoglycoprotein Antigen (FSA) as a Possible Precursor of Alimentary Canal Cancers

Häkkinen, I

doi:10.3109/00365527209180774

Cited by 8 publications

(8 citation statements)

References 10 publications

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“…Similarly we prepared 74 cancerous gastric juice samples -51 from persons in blood group A and 23 from persons in group B, as well as 28 samples from young normal controls, 17 of which belonged to blood group A and 11 to B. The antisera used were: anti-FSA serum prepared in rabbits and absorbed with salivary glycoproteins of a normal young person in blood group O as described earlier [9,11]; anti-N" serum prepared by immunizing rabbits with normal gastric glycoprotein antigen [11,15] and hyper-immune human anti-A and anti-B sera (standard preparations from the Finnish Red Cross Transfusion Centre). The blood group antisera were selected and tested to give a specific precipitation line in the Ouchterlony plate against compatible blood group glycoproteins of ovarian cyst origin.…”

Section: Methodsmentioning

confidence: 99%

“…The population study for detection of FSA in gastric juice has been described earlier [10,12]. The samples were collected for the most part from industrial workers (about 12,000 persons) and the remainder from an unselected rural population (about 2,000 persons).…”

Section: Methodsmentioning

confidence: 99%

“…The study was restrict ed to the age group from 40 to 70 years. Acid glycoproteins were isolated front gastric juice, using precipitation with cetylpyridinium chloride [7,10]. The samples thus obtained were analyzed for FSA in Ouchterlony plates against a specific rab bit anti-FSA serum.…”

Section: Methodsmentioning

confidence: 99%

“…Alterations in connec tion with a malignancy point to the possibility that changes occur in the course of life [14]. In our earlier study [10,12] we analyzed gastric samples from about 14,000 persons, aged 40 years or more, for the pur pose of finding fetal sulphoglycoprotein antigen (FSA). It was thought that the group of FSA positives could be regarded as a high-risk group for gastric cancer.…”

mentioning

confidence: 99%

“…According to their results it seems unlikely that the A-like antigen is identical with the true A antigen which is determined by N-acetylgalactosamine. The group of blood group glycoproteins in the stomach includes still other antigens which are believed to be organ-specific [11,13,15].…”

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confidence: 99%

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Gastric Fetal Sulphoglycoprotein Antigen (FSA) and Blood Group Antigens A and B

Häkkinen¹

1974

Int Arch Allergy Immunol

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Acid gastric glycoproteins deriving from 180 non-cancerous FSA secretors, 74 gastric cancer patients (FSA positives), and 28 young controls (FSA negatives), all in blood group A or B were analyzed for content of blood group antigens and for the relation of FSA (or N_o in young controls) to these. The Ouchterlony analysis revealed six different combinations in the same glycoprotein molecules or separately. There seemed to be a trend towards disappearance of blood group antigens in gastric cancer, although some of the non-cancerous FSA positives and gastric cancer samples showed quite a similar polydisperse picture. The glycoproteins deriving from young controls were strictly monodisperse and showed a strong positivity for blood group antigens. The practical importance of the present data lies in the fact that they provide the possibility of following the FSA blood group picture of non-cancerous FSA positives. This may warrant further clinical examinations as the picture alters.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Gastric Fetal Sulphoglycoprotein Antigen (FSA) and Blood Group Antigens A and B

Häkkinen¹

1974

Int Arch Allergy Immunol

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The detection of an antigen present in gastric carcinoma

1974

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Carcinofetal antigens. III. Further carcinofetal antigens

Lamerz

Fateh‐Moghadam

1975

Klin Wochenschr

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The occurrance and significance of important carcinofetal antigens other than AFP and CEA are reported. These included the alpha 2 H-protein which is produced in the liver and increases in serum of patients with various tumors, the fetal sulphoglycoprotein antigen FSA from the gastric juice of patients with gastric cancer, the carcinoplacental alkaline phosphatase (REGAN-isoenzyme)which is found in the serum of patients suffering from e.g. bronchogenic, mammary, urogenital and gastrointestinal carcinomas, the beta-S-fetoprotein which is most likely to be identical with C-reactive protein, gamma-fetoprotein, the carcinofetal antigen in glial tumors (CFGA); ectopic production of placental hormones like human gonadotropin, placental lactogen, plasminogen-activators; leukemia-associated antigens. Furthermore, some other less known carcinofetal antigens are mentioned.

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Foetal Sulphoglycoprotein Antigen (FSA) as a Possible Precursor of Alimentary Canal Cancers

Cited by 8 publications

References 10 publications

Gastric Fetal Sulphoglycoprotein Antigen (FSA) and Blood Group Antigens A and B

Gastric Fetal Sulphoglycoprotein Antigen (FSA) and Blood Group Antigens A and B

The detection of an antigen present in gastric carcinoma

Carcinofetal antigens. III. Further carcinofetal antigens

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