Abstract:Management of breast cancer during pregnancy is complicated by the high risks of abortion and foetal malformation from the use of radiotherapy and chemotherapy. A case of breast cancer during pregnancy, treated with radiotherapy, and the estimated foetal dose is reported.
“…Notably, there have been case reports of normal infants born to irradiated mothers and successful radiation therapy for Hodgkin disease during pregnancy with appropriate supplemental shielding [32,45,[47][48][49]. Additionally, the 2006 international recommendations from an expert meeting published by Loibl and colleagues [4] regarding therapeutic irradiation have recently been challenged by authors who feel the risks of fetal irradiation exposure have been overestimated [49].…”
Section: Irradiationmentioning
confidence: 99%
“…Although 80% of these masses are benign, further evaluation is warranted if findings persist more than 2 to 4 weeks [7,32]. Evaluation begins with a thorough clinical examination, and a baseline breast examination is recommended at the first prenatal visit [4].…”
Breast cancer, along with cervical cancer, is one of the most commonly diagnosed cancers of pregnancy. Most would define gestational breast cancer as breast cancer that is diagnosed during pregnancy, lactation, and up to 12 months post-partum. The diagnostic and therapeutic implications in this clinical setting are special. These women typically present with a more advanced-stage disease that carries an associated poorer prognosis. Physicians thus are challenged to balance aggressive maternal care with appropriate modifications that will ensure fetal protection. . Of women diagnosed with breast cancer younger than 40 years, only approximately 10% will be pregnant [2,3]. These data certainly suggest a low incidence of pregnancy-associated breast cancer. In fact, historically, the incidence is estimated at 1 in 3000 pregnancies [4][5][6]. Despite the overall low incidence, however, gestational breast cancer is one of the most common pregnancy-associated malignancies, second only to cervical cancer [4,6]. Notably, many have offered that this incidence will only increase as more women delay childbearing until later in life [4,7]. This concern is based on the fact that pregnancy-associated breast cancer is age-related, and women
“…Notably, there have been case reports of normal infants born to irradiated mothers and successful radiation therapy for Hodgkin disease during pregnancy with appropriate supplemental shielding [32,45,[47][48][49]. Additionally, the 2006 international recommendations from an expert meeting published by Loibl and colleagues [4] regarding therapeutic irradiation have recently been challenged by authors who feel the risks of fetal irradiation exposure have been overestimated [49].…”
Section: Irradiationmentioning
confidence: 99%
“…Although 80% of these masses are benign, further evaluation is warranted if findings persist more than 2 to 4 weeks [7,32]. Evaluation begins with a thorough clinical examination, and a baseline breast examination is recommended at the first prenatal visit [4].…”
Breast cancer, along with cervical cancer, is one of the most commonly diagnosed cancers of pregnancy. Most would define gestational breast cancer as breast cancer that is diagnosed during pregnancy, lactation, and up to 12 months post-partum. The diagnostic and therapeutic implications in this clinical setting are special. These women typically present with a more advanced-stage disease that carries an associated poorer prognosis. Physicians thus are challenged to balance aggressive maternal care with appropriate modifications that will ensure fetal protection. . Of women diagnosed with breast cancer younger than 40 years, only approximately 10% will be pregnant [2,3]. These data certainly suggest a low incidence of pregnancy-associated breast cancer. In fact, historically, the incidence is estimated at 1 in 3000 pregnancies [4][5][6]. Despite the overall low incidence, however, gestational breast cancer is one of the most common pregnancy-associated malignancies, second only to cervical cancer [4,6]. Notably, many have offered that this incidence will only increase as more women delay childbearing until later in life [4,7]. This concern is based on the fact that pregnancy-associated breast cancer is age-related, and women
“…34 Successful breast cancer RT during pregnancy and birth of healthy children has been reported. 29,33,35 A patient in week 24 of her pregnancy was treated for a ductal carcinoma with 10 MV X-rays to a total dose of 50 Gy. 33 Lead shields of 4-cm thickness were used and the measured fetal dose was 0.16 Gy; without shielding the dose would have been 0.28 Gy.…”
Section: Breast Cancermentioning
confidence: 99%
“…3 months after treatment this patient gave birth to a healthy son. Ngu et al treated a patient in the third trimester with a total dose of 50 Gy to the breast with 6 MV photons 35 . With a lead shielding over the abdomen and a lead block inferior to the breast the estimated fetal dose was 0.14-0.18 Gy.…”
Organ malformations and mental retardation (the sensitivity is high from 2 to 8 weeks, and 8 to 25 weeks after conception, respectively) are the most serious results of fetal exposure to radiation that are observed after birth and probably arise above a threshold dose of 0.1-0.2 Gy. This threshold dose is not generally reached with curative radiotherapy during pregnancy, because most of the tumors are located sufficiently far from the fetus and that precautions have been taken to protect the unborn child against leakage radiation and collimator scatter. Generally, pregnant women with malignant diseases are advised to delay the radiotherapy until after delivery. If a pregnant patient necessitates radiotherapy the physician should inform the risk of the fetus and the benefits of the mother. Subjects like week of pregnancy, stage of the disease and radiation safety must be discussed in details and the final decision should be taken by the patient. In this review, patients who were exposed to radiation during pregnancy because of radiotherapy and their fetal exposure were discussed.
“…Van der Giessen'in yayınladığı bir olgusunda 24. gebelik haftasında invaziv duktal karsinom tanısıyla total dozu 50 Gy olan tedavi rejimi uygulanmış, tedaviden üç ay sonra sağlıklı bir erkek çocuğu doğurtulduğunu bildirmiştir. Antypas ve arkadaşları ilk trimesterdeki bir olguyu toplam 46 Gy'i bulan doz rejimiyle, Ngu ve arkadaşları da üçüncü trimesterdeki bir olguyu toplam 50 Gy'lik dozla tedavi ettiklerini bildirmişlerdir (22)(23)(24). Olgularımız arasında gebeliğinin 6. haftasında tanı almış, sağ meme lumpektomi sonrasında toplam dozu 46 Gy olan rejim ile tedavi edilmiş bir olgu bulunmaktadır.…”
The aim of this paper is to present 11 cases of patients diagnosed with breast cancer during pregnancy and their perinatal outcomes. Material and methods: A retrospective analysis of 11 cases of breast cancer diagnosed during pregnancy between 2010-2015 was conducted in our clinic. In addition, the parents were surveyed regarding the health outcomes of the children exposed to chemotherapy and radiotherapy in utero. Results: Mean maternal age was 33,7±4,7 , mean parity was 1,6±1,2 . All patients had invasive ductal carsinoma histopathologically. Mean gestational age during the diagnosis was 21,9±9,3 weeks . Any treatment had given for three patients (%27,3) during the pregnancy. Two patients operated (%22,2), one patient exposed only chemotherapy (%7,1), four patients operated and exposed adjuvant chemotherapy (%36,3), one patient operated and exposed radiotherapy (%7,1) during pregnancy. Mean gestational age at the delivery was 36,7±3,4 weeks and all neonates were appropriate for gestational age. The children exposed any kind of treatment in utero were normally without any significant exposured-related toxicity or health problems. Conclusion: Pregnant women with breast cancer can be treated safely without concerns for serious complications or short-term health concerns for their offspring during the second and third trimesters.
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