Fœtal and neonatal hepatitis and its sequelæ

Heredity in Common Diseases

“…Our results in infective hepatitis are not conclusive, but they are suggestive enough to warrant further study (Debrd, 1939;Parsons, 1939;Dible et al, 1954;Singh et al, 1961). We cannot explain our findings in tuberculosis nor why this type of infection should not follow the pattern of susceptibility in other chest infections.…”

Jaundice and Infantile Diarrhoea

“…Thus although three cases (Cases 8, 9 and 11) had received blood transfusions, the microscopical features (many bile thrombi in all three, moderate periportal fibrosis in two and bile duct proliferation in the third) could hardly be attributed to haemolysis. Next, the only resemblance to neonatal hepatitis as described by Dible, Hunt, Pugh, Steingold and Wood (1954) was the presence of haemosiderosis in seven cases. A similar degree of iron pigmentation was noted in several cases of infantile diarrhoea without the hepatic lesions described above, and it was considered therefore to be a relatively non-specific finding.…”

Congenital Absence of the Intrahepatic Bile Ducts

“…There is, however, a mortality rate of 20 % and a further 100 of patients develop cirrhosis of the liver (Gellis, Craig and Hsia, 1954). The microscopical picture during the neonatal stage shows marked variation in the size of the liver cells, with distorted multinucleated giant cells scattered throughout the liver substance (Craig and Landing, 1952;Bodian and Newns, 1953 (Bodian and Newns, 1953;Dible, Hunt, Pugh, Steingold and Wood, 1954). In the bile-inspissation syndrome of Lightwood and Bodian (1946) prolonged haemolytic jaundice due to Rhesus incompatibility became complicated by biliary obstruction; this they showed histologically to be associated with inspissation of bile in the canaliculi.…”