Focusing on fatty acid profile in milk from different species after in vitro digestion

Santillo, Antonella; Figliola, Lucia; Ciliberti, Maria Giovanna; Caroprese, Mariangela; Marino, R.; Albenzio, Marzia

doi:10.1017/s0022029918000274

Cited by 16 publications

(13 citation statements)

References 22 publications

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“…Acetate, butyrate, and formate have been found in HM of women worldwide (20)(21)(22)(23)(24)(25)(26) (20)(21)(22). We also confirm the positive correlations of HM acetate with butyrate and formate reported by Prentice et al The failure by us and others to detect propionate in HM is curious.…”

Section: Discussionsupporting

confidence: 88%

“…All three of these SCFAs were identified by nuclear magnetic resonance (NMR) at 1-2 months postpartum in a larger study of women (22). Butyrate has also been documented in studies of HM fat or fatty acids (23,24). Meng et al reported the presence of acetate and butyrate in HM from women with and without irritable bowel disease, finding higher acetate levels in women treated with aminosalicylates (25).…”

Section: Introductionmentioning

confidence: 94%

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Human Milk From Atopic Mothers Has Lower Levels of Short Chain Fatty Acids

et al. 2020

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Short chain fatty acids (SFCAs) are microbial metabolites produced in the gut upon fermentation of dietary fiber. These metabolites interact with the host immune system and can elicit epigenetic effects. There is evidence to suggest that SCFAs may play a role in the developmental programming of immune disorders and obesity, though evidence in humans remains sparse. Here we have quantified human milk (HM) SCFA levels in an international cohort of atopic and non-atopic mothers (n = 109). Our results demonstrate that human milk contains detectable levels of the SCFAs acetate, butyrate, and formate. Samples from atopic mothers had significantly lower concentrations of acetate and butyrate than those of non-atopic mothers. HM SCFA levels in atopic and non-atopic women also varied based on maternal country of residence (Australia, Japan, Norway, South Africa, USA). Reduced exposure to HM SCFA in early life may program atopy or overweight risk in breastfed infants.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 94%

Human Milk From Atopic Mothers Has Lower Levels of Short Chain Fatty Acids

et al. 2020

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“…The atherogenic and thrombogenic indices, calculated on fatty acid composition, candidate equine milk as an interesting food for people with allergic and inflammatory conditions [28,64]. Moreover, the fatty acids profile detected after in vitro digestion shows significant differences depending on the milk sources, with a prevalence of saturated fatty acids released from both human and donkey milk [65]. Heat damages have been observed in donkey's milk on functional lipid compounds, which may also directly and indirectly influence gut environment and immunoinflammatory functions [66,67].…”

Section: Functional and Bioactive Compoundsmentioning

confidence: 99%

Equine Milk Production and Valorization of Marginal Areas—A Review

Miraglia

Salimei

Fantuz

2020

Animals

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The equine dairy chain is renewing the interest toward horse and donkey breeding for the production of milk with potential health promoting properties. The dairy equine chain for human consumption could contribute to the rural eco-sustainable development for the micro-economies of those areas threatened by marginalization. As a part of the whole equine industry, and its possible impact in the modern and future society, the main traits of the equine dairy enterprise are reviewed with a special focus on management of animals and milk. Equine milk compositional and nutritional peculiarities are described as also related to milk hygiene and health issues. Scientific and technical aspects of the feeding management are considered in the frame of the emerging dairy equine enterprise, where pasture is an essential element that allows to match production goals for horses and donkeys, biodiversity preservation, as well as landscape safeguard.

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“…Milk sources were previously subjected to in vitro digestion according to Minekus et al (2014). Free fatty acids in digested milk sources were analyzed as described in Santillo et al (2018) and are reported in online Supplementary Table 2S.…”

Section: Milk Treatmentsmentioning

confidence: 99%

Effect of lipid fraction of digested milk from different sources in mature 3T3-L1 adipocyte

Santillo

Figliola

Caroprese

et al. 2019

Journal of Dairy Research

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We evaluated the effect of in vitro digested milk on mature adipocytes 3T3-L1, paying particular attention to its fatty acid composition, and comparing human (HM), donkey (DM), bovine (BM), ovine (OM), caprine (CM) and formula (FM) milk. Cellular viability, apoptosis, oxidative response and gene expression levels of NF-κB p65, HMGB1, SREBP-1c and FAS were evaluated. Digested milk treatments significantly reduced 3T3-L1 mature adipocytes viability and caspase activity compared with control group, but no significant differences were observed among different sources of digested milk. In all digested milk samples, ROS level was higher than the control, however, the digested human and formula milk showed lower levels of ROS than DM, BM, OM and CM samples. Lower capacity of HM and FM to induce oxidative stress in mature adipocytes was ascribed to the peculiar free fatty acids profile of digested milk samples. All milk treatments elicited a significant over-expression of NF-κB p65 in 3T3-L1 adipocytes compared to the control; the lowest gene expression was found in HM, BM, OM and CM, the highest in FM and an intermediate behavior was shown in DM. All digested milk treatments influenced the gene expression of SRBP-1c with FM and HM showing the highest levels. For FAS expression, BM showed the highest level, OM and CM intermediate and FM, HM and DM the lowest levels, however HM and DM had comparable levels to the control.

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Focusing on fatty acid profile in milk from different species after in vitro digestion

Cited by 16 publications

References 22 publications

Human Milk From Atopic Mothers Has Lower Levels of Short Chain Fatty Acids

Human Milk From Atopic Mothers Has Lower Levels of Short Chain Fatty Acids

Equine Milk Production and Valorization of Marginal Areas—A Review

Effect of lipid fraction of digested milk from different sources in mature 3T3-L1 adipocyte

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