Focused Ultrasound Neuromodulation of Human <em>In Vitro</em> Neural Cultures in Multi-Well Microelectrode Arrays
Ruixing Liang,
Griffin Mess,
Joshua Punnoose
et al.
Abstract:The neuromodulatory effects of focused ultrasound (FUS) have been demonstrated in animal models, and FUS has been used successfully to treat movement and psychiatric disorders in humans. However, despite the success of FUS, the mechanism underlying its effects on neurons remains poorly understood, making treatment optimization by tuning FUS parameters difficult. To address this gap in knowledge, we studied human neurons in vitro using neurons cultured from humaninduced pluripotent stem cells (HiPSCs). Using Hi… Show more
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