Focused ultrasound: Innovation in use for neurologic conditions

Hosseini, M. Reza; Pierre, Kevin; Felisma, Patrick; Mampre, David; Fusco, Anna; Reddy, Ramya; Chandra, Vyshak; Lucke‐Wold, Brandon

doi:10.46439/trauma.1.001

Cited by 2 publications

(1 citation statement)

References 136 publications

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“…FUS uses focused ultrasound waves to temporarily disrupt the BBB in a controlled and localized manner, allowing drugs or other therapeutic agents to cross into the brain [ 12 ]. FUS could be categorized into high-intensity focused ultrasound (HIFU) and low-intensity focused ultrasound (LIFU).…”

Section: Therapeutic Strategies In Bbb Opening and Deliverymentioning

confidence: 99%

Translational strategies and systems biology insights for blood-brain barrier opening and delivery in brain tumors and Alzheimer’s disease

Song,

Plumlee,

Ahn

et al. 2023

Biomedicine & Pharmacotherapy

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Section: Therapeutic Strategies In Bbb Opening and Deliverymentioning

confidence: 99%

Translational strategies and systems biology insights for blood-brain barrier opening and delivery in brain tumors and Alzheimer’s disease

Song,

Plumlee,

Ahn

et al. 2023

Biomedicine & Pharmacotherapy

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Getting ahead of Alzheimer’s disease: early intervention with focused ultrasound

et al. 2023

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The amyloid-β (Aβ) hypothesis implicates Aβ protein accumulation in Alzheimer’s disease (AD) onset and progression. However, therapies targeting Aβ have proven insufficient in achieving disease reversal, prompting a shift to focus on early intervention and alternative therapeutic targets. Focused ultrasound (FUS) paired with systemically-introduced microbubbles (μB) is a non-invasive technique for targeted and transient blood–brain barrier opening (BBBO), which has demonstrated Aβ and tau reduction, as well as memory improvement in models of late-stage AD. However, similar to drug treatments for AD, this approach is not sufficient for complete reversal of advanced, symptomatic AD. Here we aim to determine whether early intervention with FUS-BBBO in asymptomatic AD could delay disease onset. Thus, the objective of this study is to measure the protective effects of FUS-BBBO on anxiety, memory and AD-associated protein levels in female and male triple transgenic (3xTg) AD mice treated at an early age and disease state. Here we show that early, repeated intervention with FUS-BBBO decreased anxiety-associated behaviors in the open field test by 463.02 and 37.42% in male and female cohorts, respectively. FUS-BBBO preserved female aptitude for learning in the active place avoidance paradigm, reducing the shock quadrant time by 30.03 and 31.01% in the final long-term and reversal learning trials, respectively. Finally, FUS-BBBO reduced hippocampal accumulation of Aβ40, Aβ42, and total tau in females by 12.54, 13.05, and 3.57%, respectively, and reduced total tau in males by 18.98%. This demonstration of both cognitive and pathological protection could offer a solution for carriers of AD-associated mutations as a safe, non-invasive technique to delay the onset of the cognitive and pathological effects of AD.

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Focused ultrasound: Innovation in use for neurologic conditions

Cited by 2 publications

References 136 publications

Translational strategies and systems biology insights for blood-brain barrier opening and delivery in brain tumors and Alzheimer’s disease

Translational strategies and systems biology insights for blood-brain barrier opening and delivery in brain tumors and Alzheimer’s disease

Getting ahead of Alzheimer’s disease: early intervention with focused ultrasound

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