Focused Ultrasound, an Emerging Tool for Atherosclerosis Treatment: A Comprehensive Review

Imtiaz, Cynthia; Farooqi, Muhammad Awais; Bhatti, Theophilus; Lee, Jooho; Moin, Ramsha; Kang, Chul Ung; Farooqi, Hafiz Muhammad Umer

doi:10.3390/life13081783

Cited by 5 publications

(3 citation statements)

References 86 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Considerable attention has been directed toward preclinical and clinical studies exploring the application of therapeutic FUS in managing colorectal cancer [80]. Over the past twenty years, more than 3500 patients diagnosed with colorectal cancer have undergone palliative therapy utilizing thermally ablative HIFU [81]. These interventions have shown feasibility, safety, and effectiveness, offering pain relief and, in some instances, tumor growth control [21].…”

Section: Utilizing Therapeutic Focused Ultrasound For Colorectal Canc...mentioning

confidence: 99%

Focused Ultrasound as Targeted Therapy for Colorectal Cancer: A Comprehensive Review

Farooqi,

Mahnoor,

Delgado

et al. 2024

Gastrointestinal Disorders

Self Cite

View full text Add to dashboard Cite

Traditional cancer treatments have not significantly improved the survival rates for individuals with colorectal cancer. As a result, there is a dire need to explore novel treatment modalities that can target cancer-specific niches, transform cold colorectal tumors into hot ones, and disrupt the tumor niche. Therapeutic focused ultrasound, recognized for its capacity to induce thermal and mechanical impacts on tissue, can potentially eliminate cancer cells and elicit the body’s anticancer reaction by disrupting the tumor microenvironment. This article provides an overview of recent developments in employing therapeutic focused ultrasound (TFUS) to enhance the body’s natural defenses against colorectal cancers. It also discusses studies examining the utility of TFUS in treating colorectal cancer patients and recent research indicating its potential to stimulate the body’s anticancer response in various in vitro and in vivo colorectal cancer models. Furthermore, it explores the therapeutic effects of TFUS on the immune system in colorectal cancers. This article also highlights the safety and effectiveness of TFUS in managing colorectal cancer, providing relief from pain, and potentially improving survival rates. Given the indications that TFUS may bolster the body’s immune response and augment the impacts of TFUS therapy in clinical and preclinical colorectal cancer models, it has the potential to emerge as a pivotal tool in clinical settings.

show abstract

Section: Utilizing Therapeutic Focused Ultrasound For Colorectal Canc...mentioning

confidence: 99%

Focused Ultrasound as Targeted Therapy for Colorectal Cancer: A Comprehensive Review

Farooqi,

Mahnoor,

Delgado

et al. 2024

Gastrointestinal Disorders

Self Cite

View full text Add to dashboard Cite

show abstract

“…Precisely regulating acoustic treatments at temperatures between 40 • C and 90 • C makes the system suitable for a variety of non-ablative and ablative applications in dermatological treatment [8]. The ability to tailor the treatment parameters, such as power, pulse duration, and focal penetration depth, allows for the customization of the treatment process, ensuring that the desired therapeutic outcome is achieved with precision [10].…”

Section: Introductionmentioning

confidence: 99%

Healing Process after High-Intensity Focused Ultrasound Treatment of Benign Skin Lesions: Dermoscopic Analysis and Treatment Guidelines

Calik,

Zawada,

Bove

et al. 2024

JCM

View full text Add to dashboard Cite

Background: High-Intensity Focused Ultrasound (HIFU) has emerged as a precise and non-invasive modality for tissue ablation and healing. This study presents a detailed dermoscopic analysis of skin healing post-High-Intensity Focused Ultrasound (HIFU) treatment, focusing on common benign skin lesions, such as seborrheic keratosis, sebaceous hyperplasia, vascular lesions, and sebaceous nevi. Methods: Prior to HIFU treatment, a comprehensive assessment was conducted, integrating ultrasound scanning and clinical evaluations. The TOOsonix System ONE-M was employed for HIFU treatments, with parameters tailored to each lesion type. Results: A common pattern observed across all lesions includes initial whitening post treatment, followed by scab formation and the development of a pink area with reparative vessels. This study, however, highlights distinct differences in fibrosis patterns and healing timelines across different lesion types. Each lesion type exhibited unique fibrosis patterns post treatment. Flatter variants of seborrheic keratosis healed within a month, displaying hypopigmentation and reparative vessels, alongside a distinct lattice fibrosis pattern in more verrucous forms, which took about two months to heal. Sebaceous hyperplasia, characterized by rapid healing within three weeks, demonstrated fibrosis with pink areas and perpendicular white lines, concluding with a slight depression. Vascular lesions varied in healing time based on depth, with superficial ones showing whitening and crust formation, while deeper lesions had vessel occlusion and size reduction accompanied by concentric fibrotic bands. Sebaceous nevi presented the longest healing duration of three months, characterized by amorphous white-gray structures, scab formation, and the emergence of pink areas with branching vessels, leading to clear skin with reduced white lines. Conclusions: in conclusion, this meticulous clinical evaluation highlights the unique healing characteristics and timelines for each skin lesion type treated with HIFU. These insights are invaluable for optimizing follow-up assessments, identifying potential complications, and refining treatment protocols. By providing detailed insights into the healing timelines and patterns for different types of lesions, patients can be better informed about their post-treatment journey.

show abstract

“…To evaluate the impact of cavitation on abdominal fat, researchers utilize various medical imaging techniques, including ultrasound, CT, MRI, and DXA. These methods provide detailed assessments of fat distribution and volume, facilitating the monitoring of treatment outcomes 13 . The optimization of fat prediction models stands as a central focus in this research, employing advanced hyperparameter optimization techniques.…”

Section: Introductionmentioning

confidence: 99%

Employing machine learning for enhanced abdominal fat prediction in cavitation post-treatment

Abdel Hady,

Mabrouk,

Abd El-Hafeez

2024

Sci Rep

View full text Add to dashboard Cite

This study investigates the application of cavitation in non-invasive abdominal fat reduction and body contouring, a topic of considerable interest in the medical and aesthetic fields. We explore the potential of cavitation to alter abdominal fat composition and delve into the optimization of fat prediction models using advanced hyperparameter optimization techniques, Hyperopt and Optuna. Our objective is to enhance the predictive accuracy of abdominal fat dynamics post-cavitation treatment. Employing a robust dataset with abdominal fat measurements and cavitation treatment parameters, we evaluate the efficacy of our approach through regression analysis. The performance of Hyperopt and Optuna regression models is assessed using metrics such as mean squared error, mean absolute error, and R-squared score. Our results reveal that both models exhibit strong predictive capabilities, with R-squared scores reaching 94.12% and 94.11% for post-treatment visceral fat, and 71.15% and 70.48% for post-treatment subcutaneous fat predictions, respectively. Additionally, we investigate feature selection techniques to pinpoint critical predictors within the fat prediction models. Techniques including F-value selection, mutual information, recursive feature elimination with logistic regression and random forests, variance thresholding, and feature importance evaluation are utilized. The analysis identifies key features such as BMI, waist circumference, and pretreatment fat levels as significant predictors of post-treatment fat outcomes. Our findings underscore the effectiveness of hyperparameter optimization in refining fat prediction models and offer valuable insights for the advancement of non-invasive fat reduction methods. This research holds important implications for both the scientific community and clinical practitioners, paving the way for improved treatment strategies in the realm of body contouring.

show abstract

Focused Ultrasound, an Emerging Tool for Atherosclerosis Treatment: A Comprehensive Review

Cited by 5 publications

References 86 publications

Focused Ultrasound as Targeted Therapy for Colorectal Cancer: A Comprehensive Review

Focused Ultrasound as Targeted Therapy for Colorectal Cancer: A Comprehensive Review

Healing Process after High-Intensity Focused Ultrasound Treatment of Benign Skin Lesions: Dermoscopic Analysis and Treatment Guidelines

Employing machine learning for enhanced abdominal fat prediction in cavitation post-treatment

Contact Info

Product

Resources

About