Focus on the Possible Role of Dietary Sodium, Potassium, Phosphate, Magnesium, and Calcium on CKD Progression

Mazzaferro, Sandro; Martini, Natalia De; Cannata‐Andía, Jorge B.; Cozzolino, Mario; Rotondi, Silverio; Tartaglione, Lida; Pasquali, Marzia

doi:10.3390/jcm10050958

Cited by 14 publications

(11 citation statements)

References 68 publications

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“…It is typically instituted to avoid negative cardiac effects of hyperkalemia, but overly aggressive K + restriction could be harmful to the kidneys in the long term. While findings from several studies have supported this hypothesis, 20 , 21 others have not. 22 , 23 Moreover, clinical studies have been observational, making mechanistic inferences difficult.…”

Section: Discussionmentioning

confidence: 98%

Kir4.2 mediates proximal potassium effects on glutaminase activity and kidney injury

Terker¹,

Zhang²,

Arroyo³

et al. 2022

Cell Reports

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Section: Discussionmentioning

confidence: 98%

Kir4.2 mediates proximal potassium effects on glutaminase activity and kidney injury

Terker¹,

Zhang²,

Arroyo³

et al. 2022

Cell Reports

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“…In particular, it is widely acknowledged that renal failure patients develop a severe type of vascular calcification which is pathogenically linked to the derangements in mineral metabolism and of calcium, phosphate, and VitD. Available therapies are based on restriction of dietary phosphate load and/or administration of drugs chelating phosphate in the foods [15]. Despite this, more effective strategies are needed.…”

Section: Discussionmentioning

confidence: 99%

In vitro evaluation of the calcification inhibitory properties of Policosanol, Genistein and Vitamin D (Reduplaxin®) either alone or in combination

Iacobini,

Fassino,

Mazzaferro

et al. 2024

Kidney Blood Press Res

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Introduction: The process of vascular calcification has severe clinical consequences in a number of diseases, including diabetes, atherosclerosis, and end-stage renal disease. In the present study, we investigated the effect of Policosanol, Genistein and Vitamin D separately and in association to evaluate the possible synergistic action on inorganic phosphate (Pi)-induced calcification of Vascular Smooth Muscle Cells (VSMCs) Methods: Primary Human VSMCs were cultured with either Growth Medium or Growth medium Supplemented with Calcium and Phosphorus (Calcification Medium) in combination with Policosanol, Genistein and Vitamin D. Alizarin red staining, Mineralization and the protein expression of RUNX2 and Superoxide Dismutase-2 (SOD-2) were investigated. Results: All three substances tested were effective at reducing osteogenic differentiation of VSMCs in a dose-dependent manner. Poli+Gen, Poli+VitD, Gen+VitD treatment induced a greater inhibition of calcification and RUNX2 expression compared to single compounds treatments. Moreover the association of Poli+Gen+VitD (Reduplaxin®) was more effective at inhibiting VSMCs mineralization and preventing the increase in RUNX-2 expression induced by Calcification Medium but not modified SOD-2 expression. Conclusions: The association of Pol, Gen and Vit D (Reduplaxin®) has an additive inhibitory effect on the calcification process of VSMCs induced in vitro by a pro-calcifying medium.

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“…Dietary guidance. 11 Professional dietitians assess the nutritional status of CKD patients, and then give appropriate dietary guidance according to their nutritional problems. Dietary review analysis software and appropriate dietary models are employed to guide patient intake and diet.…”

Section: Mdt Treatment and Traditional Clinical Treatmentmentioning

confidence: 99%

The influence of multidisciplinary team clinic on the prognosis of patients with chronic kidney disease

Bian

Zhang

Shen

et al. 2022

Exp Biol Med (Maywood)

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Chronic kidney disease (CKD) seriously affects the quality of life and survival time of patients, and even affects social and national economic development. In China, how to effectively control the disease process of CKD outpatients has not been determined. A retrospective analysis was made to 100 patients with CKD. Fifty patients treated with traditional clinical treatment were in the control group, and the other fifty patients treated with multidisciplinary team (MDT) clinical treatment were in the MDT group. The prognosis of the two groups after treatment was compared, including glomerular filtration rate (GFR), number of renal replacement treatments, and mortality, to evaluate the actual effect of MDT clinic. CKD patients in the MDT group received the MDT clinic for 24 months. There was no significant difference between GFR and serum creatinine level before treatment, and the quality of life was significantly higher than before. In the control group, the GFR declined more dramatically, the serum creatinine level was higher, and the quality of life was lower than before ( P < 0.05). The frequency of renal replacement therapy and mortality in the MDT group were significantly lower than those in the control group ( P < 0.05). MDT clinic can effectively improve the prognosis of patients with CKD, delay kidney disease progression, and reduce mortality.

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Focus on the Possible Role of Dietary Sodium, Potassium, Phosphate, Magnesium, and Calcium on CKD Progression

Cited by 14 publications

References 68 publications

Kir4.2 mediates proximal potassium effects on glutaminase activity and kidney injury

Kir4.2 mediates proximal potassium effects on glutaminase activity and kidney injury

In vitro evaluation of the calcification inhibitory properties of Policosanol, Genistein and Vitamin D (Reduplaxin®) either alone or in combination

The influence of multidisciplinary team clinic on the prognosis of patients with chronic kidney disease

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