Focus on long non-coding RNA MALAT1: Insights into acute and chronic lung diseases

Lai, Xing-Ning; Zhong, Jie; Zhang, Aihua; Zhang, Boyi; Zhu, Tao; Ren, Lei-Ming

doi:10.3389/fgene.2022.1003964

Cited by 12 publications

(7 citation statements)

References 145 publications

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“…MALAT1 can worsen ALI conditions by interacting with different miRNAs [ 85 ]. MALAT1 can downregulate specific miRNAs and can ultimately facilitate the pathogenesis of ALI [ 86 ]. Overexpressed MALAT1 also sponges specific miRNAs, which can exacerbate inflammation.…”

Section: Lncrnas In Ali/ardsmentioning

confidence: 99%

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Long Noncoding RNA: A Novel Insight into the Pathogenesis of Acute Lung Injury

Dutta

Zhu²,

Han³

et al. 2023

JCM

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Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), represent an acute stage of lung inflammation where the alveolar epithelium loses its functionality. ALI has a devastating impact on the population as it not only has a high rate of incidence, but also has high rates of morbidity and mortality. Due to the involvement of multiple factors, the pathogenesis of ALI is complex and is not fully understood yet. Long noncoding RNAs (lncRNAs) are a group of non-protein-coding transcripts longer than 200 nucleotides. Growing evidence has shown that lncRNAs have a decisive role in the pathogenesis of ALI. LncRNAs can either promote or hinder the development of ALI in various cell types in the lungs. Mechanistically, current studies have found that lncRNAs play crucial roles in the pathogenesis of ALI via the regulation of small RNAs (e.g., microRNAs) or downstream proteins. Undoubtedly, lncRNAs not only have the potential to reveal the underlying mechanisms of ALI pathogenesis but also serve as diagnostic and therapeutic targets for the therapy of ALI.

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Section: Lncrnas In Ali/ardsmentioning

confidence: 99%

“…MALAT1 sponges miR-181a-5p by negatively regulating it. MALAT1 is overexpressed and miR-181a-5p is downregulated in ALI [ 86 ]. Either MALAT1 knockdown or miR-181a-5p overexpression reduces Fas and subsequently suppresses apoptosis and inflammation.…”

Section: Lncrnas In Ali/ardsmentioning

confidence: 99%

Long Noncoding RNA: A Novel Insight into the Pathogenesis of Acute Lung Injury

Dutta

Zhu²,

Han³

et al. 2023

JCM

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“…As one of the first lncRNAs discovered, metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been linked to the pathophysiology of inflammatory illnesses, metabolic diseases, and cancer [ 40 , 41 , 42 ]. As discovered by Gu et al [ 43 ], the early inflammatory response of acinar cells may include a “MALAT1-miR-194-yes-associated protein 1 (YAP1)” mutual feedback loop.…”

Section: Exosome-specific Ncrnasmentioning

confidence: 99%

Fighting Fire with Fire: Exosomes and Acute Pancreatitis-Associated Acute Lung Injury

et al. 2022

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Acute pancreatitis (AP) is a prevalent clinical condition of the digestive system, with a growing frequency each year. Approximately 20% of patients suffer from severe acute pancreatitis (SAP) with local consequences and multi-organ failure, putting a significant strain on patients’ health insurance. According to reports, the lungs are particularly susceptible to SAP. Acute respiratory distress syndrome, a severe type of acute lung injury (ALI), is the primary cause of mortality among AP patients. Controlling the mortality associated with SAP requires an understanding of the etiology of AP-associated ALI, the discovery of biomarkers for the early detection of ALI, and the identification of potentially effective drug treatments. Exosomes are a class of extracellular vesicles with a diameter of 30–150 nm that are actively released into tissue fluids to mediate biological functions. Exosomes are laden with bioactive cargo, such as lipids, proteins, DNA, and RNA. During the initial stages of AP, acinar cell-derived exosomes suppress forkhead box protein O1 expression, resulting in M1 macrophage polarization. Similarly, macrophage-derived exosomes activate inflammatory pathways within endothelium or epithelial cells, promoting an inflammatory cascade response. On the other hand, a part of exosome cargo performs tissue repair and anti-inflammatory actions and inhibits the cytokine storm during AP. Other reviews have detailed the function of exosomes in the development of AP, chronic pancreatitis, and autoimmune pancreatitis. The discoveries involving exosomes at the intersection of AP and acute lung injury (ALI) are reviewed here. Furthermore, we discuss the therapeutic potential of exosomes in AP and associated ALI. With the continuous improvement of technological tools, the research on exosomes has gradually shifted from basic to clinical applications. Several exosome-specific non-coding RNAs and proteins can be used as novel molecular markers to assist in the diagnosis and prognosis of AP and associated ALI.

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“…8 The aberrant expression of lncRNAs has also been suggested to correlate with inflammatory lung diseases including COPD. 9,10 Liu et al identified many dysexpressed lncRNAs in the blood samples of patients with COPD via high-throughput RNA sequencing. 11 Zong et al reported that the lncRNA CCAT1 is overexpressed in COPD tissues, whereas its knockdown ameliorated cigarette smoke extract (CSE)-induced inflammation.…”

Section: Introductionmentioning

confidence: 99%

“…For example, lncRNA BC069792 functions as a tumor suppressor in breast cancer by upregulating Potassium Voltage‐Gated Channel Q4 through the adsorption of hsa‐miR‐658 and hsa‐miR‐4739 8 . The aberrant expression of lncRNAs has also been suggested to correlate with inflammatory lung diseases including COPD 9,10 . Liu et al identified many dysexpressed lncRNAs in the blood samples of patients with COPD via high‐throughput RNA sequencing 11 .…”

Section: Introductionmentioning

confidence: 99%

Suppression of long noncoding RNA SNHG6 alleviates cigarette smoke‐induced lung inflammation by modulating NF‐κB signaling

Yang,

Yuan,

Wang

et al. 2024

Environmental Toxicology

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BackgroundChronic obstructive pulmonary disease (COPD) is a widespread inflammatory disease with a high mortality rate. Long noncoding RNAs play important roles in pulmonary diseases and are potential targets for inflammation intervention.MethodsThe expression of small nucleolar RNA host gene 6 (SNHG6) in mouse lung epithelial cell line MLE12 with or without cigarette smoke extract (CSE) treatment was first detected using quantitative reverse‐transcription PCR. ELISA was used to evaluate the release of inflammatory cytokines (TNF‐α, IL‐1β, and IL‐6). The binding site of miR‐182‐5p with SNHG6 was predicted by using miRanda, which was verified by double luciferase reporter assay.ResultsHere, we revealed that SNHG6 was upregulated in CS‐exposed MLE12 alveolar epithelial cells and lungs from COPD‐model mice. SNHG6 silencing weakened CS‐induced inflammation in MLE12 cells and mouse lungs. Mechanistic investigations revealed that SNHG6 could upregulate IκBα kinase through sponging the microRNA miR‐182‐5p, followed by activated NF‐κB signaling. The suppressive effects of SNHG6 silencing on CS‐induced inflammation were blocked by an miR‐182‐5p inhibitor.ConclusionOverall, our findings suggested that SNHG6 regulates CS‐induced inflammation in COPD by activating NF‐κB signaling, thereby offering a novel potential target for COPD treatment.

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Focus on long non-coding RNA MALAT1: Insights into acute and chronic lung diseases

Cited by 12 publications

References 145 publications

Long Noncoding RNA: A Novel Insight into the Pathogenesis of Acute Lung Injury

Long Noncoding RNA: A Novel Insight into the Pathogenesis of Acute Lung Injury

Fighting Fire with Fire: Exosomes and Acute Pancreatitis-Associated Acute Lung Injury

Suppression of long noncoding RNA SNHG6 alleviates cigarette smoke‐induced lung inflammation by modulating NF‐κB signaling

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