Focus on levomepromazine

Abstract

This paper is an overview of recently published research concerning the neuroleptic drug aripiprazole. Aripiprazole is an antipsychotic drug with high affinity for D(2)- and D(3)-receptors and the dopamine autoreceptor. It also has serotonin 5-HT(1A)-receptor partial agonist and 5-HT(2A)-receptor antagonist properties. It is prescribed in the treatment of schizophrenia and is under the treatment of schizophrenia and schizoaffective investigation for treatment of bipolar disorder. The drug is given by mouth in an initial dose of 10 or 15 mg once daily. The dose may be adjusted at intervals of not less than 2 weeks up to a maximum of 30 mg daily. It appears to be useful in disorder and has a better side-effect profile than haloperidol.

Additional use of methotrimeprazine for treating refractory agitation in pediatric patients

“…This classic neuroleptic is commonly used as co-medication in emergency psychiatry in adults to treat acute psychosis or mania by reducing levels of agitation, anger, and aggressiveness [4], thereby improving comfort for all—the patient, family, and members of the multidisciplinary team. There is no literature to allow for advisory dosages of MTZ in children with RA; however, in palliative care 0.1 mg/kg IV/SC/8 h is suggested [1].…”

“…25–50 mg/orally/24 h MTZ are common. Potential, but rare side effects of MTZ include tardive dyskinesia, akathisia, neuroleptic malignant syndrome, and extrapyramidal and cholinergically mediated side effects; a contraindication is bone marrow depression [4]. …”

“…We conclude that once RA still continues after adequate 24-h dosages of D2-blocking agents, the addition of MTZ by trial and error titration might be a useful option [4]. We would like to reintroduce and underscore, on the basis of empirical evidence and by analogy to what is known in adults [1, 4], the use and effectiveness of MTZ in the treatment of RA in critically ill children in the PICU.…”

“…We would like to reintroduce and underscore, on the basis of empirical evidence and by analogy to what is known in adults [1, 4], the use and effectiveness of MTZ in the treatment of RA in critically ill children in the PICU.…”

Inhibition of human cytochrome P450 isoenzymes by a phenothiazine neuroleptic levomepromazine: An in vitro study

“…Levomepromazine is used for treating schizophrenia, paranoia, mania, toxic psychoses and mental organic syndromes associated with delirium. [2]. Moreover, it is also used in the therapy of nausea and vomiting in advanced cancer patients and as a sedative in terminal care and burn patients [3].…”