Focus on invasive mucormycosis in paediatric haematology oncology patients: a series of 11 cases

Phulpin-Weibel, Aurélie; Rivier, Alexandre; Leblanc, Thierry; Bertrand, Yves; Chastagner, Pascal

doi:10.1111/myc.12010

Cited by 17 publications

(28 citation statements)

References 19 publications

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“…A slight male predominance was noted during the study; however, the gender difference was not significant. This male predominance agrees with previous reports . Some authors have correlated this tendency to the protective influence of oestrogens, but this correlation may not be valid in children younger than 12 years of age.…”

Section: Discussionsupporting

confidence: 87%

“…Of the 158 confirmed cases of mucormycosis, 14% were children. In accordance with previous reports, patients with ages from 6 months to 18 years were enrolled, and the mean age was 10.3 years . A slight male predominance was noted during the study; however, the gender difference was not significant.…”

Section: Discussionsupporting

confidence: 71%

“…Most reports of mucormycosis are of isolated cases, and there are few cases series in the literature. HM is the major underlying disease in these patients …”

Section: Discussionmentioning

confidence: 99%

“…HM is the major underlying disease in these patients. [12][13][14][15][16][17][18] This study examines the paediatric mucormycosis cases of a larger cases series at a single centre. Of the 158 confirmed cases of mucormycosis, 14% were children.…”

Section: Discussionmentioning

confidence: 99%

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Mucormycosis in children: a study of 22 cases in a Mexican hospital

Bonifáz¹,

Tirado‐Sánchez²,

Calderón³

et al. 2014

Mycoses

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SummaryWe present a single-centre, retrospective study of 22 cases of mucormycosis in children. A total of 158 mucormycosis cases were identified, of which 22 (13.96%) were children. The mean age of the children was 10.3 years (range: 6 months-18 years), and 59% of the infections occurred in males. The rhinocerebral form was the main clinical presentation (77.27%), followed by the primary cutaneous and pulmonary patterns. The major underlying predisposing factors were diabetes mellitus in 68.18% of the patients and haematologic diseases in 27.7% of the patients. The cases were diagnosed by mycological tests, with positive cultures in 95.4% of the patients. Rhizopus arrhizus was the foremost aetiologic agent in 13/22 cases (59.1%). In 21 cultures, the aetiologic agents were identified morphologically and by molecular identification. In 10 cultures, the internal transcribed spacer region of the ribosomal DNA was sequenced. Clinical cure and mycological cure were achieved in 27.3% cases, which were managed with amphotericin B deoxycholate and by treatment of the underlying conditions.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 71%

“…Most reports of mucormycosis are of isolated cases, and there are few cases series in the literature. HM is the major underlying disease in these patients …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Mucormycosis in children: a study of 22 cases in a Mexican hospital

Bonifáz¹,

Tirado‐Sánchez²,

Calderón³

et al. 2014

Mycoses

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“…В ев-ропейских исследованиях основным фоновым забо-леванием у детей чаще всего отмечается острый мие-лоидный лейкоз (45 % всех больных), в аналогичном исследовании, проведенном в США, около 70 % -это больные острым лейкозом [18,19]. В группе наблюда-емых нами детей острые лейкозы также составили 64 % среди фоновых заболеваний.…”

Section: Discussionunclassified

MUCORMYCOSIS IN ONCOHEMATOLOGY PATIENTS (results of the prospective study)

Климко¹,

Хостелиди²,

Шадривова³

et al. 2017

Onkogematologiâ

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The Changing Epidemiology of Invasive Fungal Infections

Enoch

Yang

Aliyu

et al. 2016

Methods in Molecular Biology

311

208

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Invasive fungal infections (IFI) are an emerging problem worldwide with invasive candidiasis and candidemia responsible for the majority of cases. This is predominantly driven by the widespread adoption of aggressive immunosuppressive therapy among certain patient populations (e.g., chemotherapy, transplants) and the increasing use of invasive devices such as central venous catheters (CVCs). The use of new immune modifying drugs has also opened up an entirely new spectrum of patients at risk of IFIs. While the epidemiology of candida infections has changed in the last decade, with a gradual shift from C. albicans to non-albicans candida (NAC) strains which may be less susceptible to azoles, these changes vary between hospitals and regions depending on the type of population risk factors and antifungal use. In certain parts of the world, the incidence of IFI is strongly linked to the prevalence of other disease conditions and the ecological niche for the organism; for instance cryptococcal and pneumocystis infections are particularly common in areas with a high prevalence of HIV disease. Poorly controlled diabetes is a major risk factor for invasive mould infections. Environmental factors and trauma also play a unique role in the epidemiology of mould infections, with well-described hospital outbreaks linked to the use of contaminated instruments and devices. Blastomycosis is associated with occupational exposure (e.g., forest rangers) and recreational activities (e.g., camping and fishing).The true burden of IFI is probably an underestimate because of the absence of reliable diagnostics and lack of universal application. For example, the sensitivity of most blood culture systems for detecting candida is typically 50 %. The advent of new technology including molecular techniques such as 18S ribosomal RNA PCR and genome sequencing is leading to an improved understanding of the epidemiology of the less common mould and dimorphic fungal infections. Molecular techniques are also providing a platform for improved diagnosis and management of IFI.Many factors affect mortality in IFI, not least the underlying medical condition, choice of therapy, and the ability to achieve early source control. For instance, mortality due to pneumocystis pneumonia in HIV-seronegative individuals is now higher than in seropositive patients. Of significant concern is the progressive increase in resistance to azoles and echinocandins among candida isolates, which appears to worsen the already significant mortality associated with invasive candidiasis. Mortality with mould infections approaches 50 % in most studies and varies depending on the site, underlying disease and the use of antifungal agents such as echinocandins and voriconazole. Nevertheless, mortality for most IFIs has generally fallen with advances in medical technology, improved care of CVCs, improved diagnostics, and more effective preemptive therapy and prophylaxis.

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Focus on invasive mucormycosis in paediatric haematology oncology patients: a series of 11 cases

Cited by 17 publications

References 19 publications

Mucormycosis in children: a study of 22 cases in a Mexican hospital

Mucormycosis in children: a study of 22 cases in a Mexican hospital

MUCORMYCOSIS IN ONCOHEMATOLOGY PATIENTS (results of the prospective study)

The Changing Epidemiology of Invasive Fungal Infections

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