Focus on focus: lack of coherence between systemic and microvascular indices of oedema formation

Tusscher, Birkitt L ten; Gudden, Corien; Vliet, Suus Van; Smit, Bob; İnce, Can; Boerma, E. Christiaan; Grooth, Harm-Jan de; Elbers, Paul

doi:10.5603/ait.a2017.0062

Cited by 2 publications

(3 citation statements)

References 21 publications

(25 reference statements)

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“…However, considering all patient measurements, the average distance between the SM and the tissue surface was found around 160 μm. Similarly, Ten Tusscher et al [26] reported an FD of around 130 μm [22]. The purpose of their study was to identify if this variable was related to tissue edema; however, they found that there was no correlation between the severity of tissue edema and FD [26].…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, Ten Tusscher et al [26] reported an FD of around 130 μm [22]. The purpose of their study was to identify if this variable was related to tissue edema; however, they found that there was no correlation between the severity of tissue edema and FD [26]. On the other hand, this parameter has been shown to identify the presence of vaginal atrophy in a quantitative manner.…”

Section: Discussionmentioning

confidence: 99%

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Morphologic Mapping of the Sublingual Microcirculation in Healthy Volunteers

Güven

Hilty

et al. 2022

J Vasc Res

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Purpose: Monitoring the sublingual and oral microcirculation (SM-OM) using hand-held vital microscopes (HVMs) has provided valuable insight into the (patho)physiology of diseases. However, the microvascular anatomy in a healthy population has not been adequately described yet. Methods: Incident dark field-based HVM imaging was used to visualize the SM-OM. First, the SM was divided into four different fields; Field-a (between incisors-lingua), Field-b (between the canine-first premolar-lingua), Field-c (between the first-second premolar-lingua), Field-d (between the second molar-wisdom teeth-lingua). Second, we investigated the buccal area, lower and upper lip. Total/functional vessel density (TVD/FCD), focus depth (FD), small vessel mean diameters (SVMDs), and capillary tortuosity score (CTS) were compared between the areas. Results: Fifteen volunteers with a mean age of 29 ± 6 years were enrolled. No statistical difference was found between the sublingual fields in terms of TVD (p = 0.30), FCD (p = 0.38), and FD (p = 0.09). SVMD was similar in Field-a, Field-b, and Field-c (p = 0.20–0.30), and larger in Field-d (p < 0.01, p = 0.015). The CTS of the buccal area was higher than in the lips. Conclusion: The sublingual area has a homogenous distribution in TVD, FCD, FD, and SVMD. This study can be a description of the normal microvascular anatomy for future researches regarding microcirculatory assessment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Morphologic Mapping of the Sublingual Microcirculation in Healthy Volunteers

Güven

Hilty

et al. 2022

J Vasc Res

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“…Although video imaging of the microcirculation may reveal several perfusion abnormalities, it's use in quantifying tissue edema seems limited [71].…”

Section: Evaluation Of Fluid Overloadmentioning

confidence: 99%

Evaluating fluid overload in critically ill children

Bem,

Lemson

2024

Current Opinion in Pediatrics

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Purpose of review To review the evaluation and management of fluid overload in critically ill children. Recent findings Emerging evidence associates fluid overload, i.e. having a positive cumulative fluid balance, with adverse outcome in critically ill children. This is most likely the result of impaired organ function due to increased extravascular water content. The combination of a number of parameters, including physical, laboratory and radiographic markers, may aid the clinician in monitoring and quantifying fluid status, but all have important limitations, in particular to discriminate between intra- and extravascular water volume. Current guidelines advocate a restrictive fluid management, initiated early during the disease course, but are hampered by the lack of high quality evidence. Summary Recent advances in early evaluation of fluid status and (tailored) restrictive fluid management in critically ill children may decrease complications of fluid overload, potentially improving outcome. Further clinical trials are necessary to provide the clinician with solid recommendations.

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Focus on focus: lack of coherence between systemic and microvascular indices of oedema formation

Cited by 2 publications

References 21 publications

Morphologic Mapping of the Sublingual Microcirculation in Healthy Volunteers

Morphologic Mapping of the Sublingual Microcirculation in Healthy Volunteers

Evaluating fluid overload in critically ill children

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