Focalised stimulation using high definition transcranial direct current stimulation (HD-tDCS) to investigate declarative verbal learning and memory functioning

Nikolin, Stevan; Loo, Colleen; Bai, Shuxiong; Dokos, Socrates; Martin, Donel

doi:10.1016/j.neuroimage.2015.05.019

Cited by 138 publications

(97 citation statements)

References 81 publications

(69 reference statements)

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“…Our results are in line with previous studies that employed the standard 4 × 1 HD-tDCS set-up (Kuo et al, 2013; Nikolin et al, 2015; Borckardt et al, 2012; Villamar et al, 2013a, b). Only mild and self-resolved adverse effects were reported after the end of each stimulation session.…”

Section: Discussionsupporting

confidence: 93%

“…One of the most frequently used HD-tDCS montages is the 4×1 ring set-up which employs a central electrode surrounded by four return electrodes arranged in a circle around the central electrode (Dmochowski et al, 2011; Edwards et al, 2013; Villamar et al, 2013b). HD-tDCS enhances motor cortex excitability (Caparelli-Daquer et al, 2012) similar to conventional tDCS, significantly improves verbal learning and working memory in healthy individuals (Nikolin et al, 2015), improves language in patients with stroke (Richardson et al, 2015), and is well tolerated (Borckhardt et al, 2012; Brunye et al, 2014; Kuo et al, 2013; Garnett et al, 2015; Richardson et al, 2015). As with tDCS, HD-tDCS studies have also been designed to stimulate one brain area for a small number of sessions (1–10).…”

Section: Introductionmentioning

confidence: 99%

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Extended Multiple-Field High-Definition transcranial direct current stimulation (HD-tDCS) is well tolerated and safe in healthy adults

Turski

Kessler-Jones

Chow

et al. 2017

RNN

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Background High definition transcranial direct current stimulation (HD-tDCS) has been administered over single brain regions for small numbers of sessions. Safety, feasibility and tolerability of HD-tDCS over multiple brain regions, multiple daily stimulations and long periods are not established. Objective We studied safety, feasibility and tolerability of daily HD-tDCS over 2–4 brain regions for 20 sessions in healthy adults. Methods Five healthy adults underwent physical and neurological examination, electrocardiogram (EKG), electroencephalogram (EEG) and cognitive screening (ImpACT) before, during and after HD-tDCS. Four networks (left/right temporoparietal and frontal) were stimulated in sequence (20 min each) using HD-tDCS in 20 daily sessions. Sessions 1–10 included sequential stimulation of both temporoparietal networks, sessions 11–15 stimulations of 4 networks and sessions 16–20 two daily stimulation cycles of 4 networks/cycle (1.5 mA/network). Side effects, ImpACT scores and EEG power spectrum were compared before and after HD-tDCS. Results All subjects completed the trial. Adverse events were tingling, transient redness at the stimulation site, perception of continuing stimulation after end of session and one self-resolving headache. EEG power spectrum showed decreased delta power in frontal areas several days after HD-tDCS. While at the group level ImpACT scores did not differ before and after stimulations, we found a trend for correlation between decreased EEG delta power and individual improvements in ImpACT scores after HD-tDCS. Conclusion Prolonged, repeat daily stimulation of multiple brain regions using HD-tDCS is feasible and safe in healthy adults. Preliminary EEG results suggest that HD-tDCS may induce long lasting changes in excitability in the brain.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Extended Multiple-Field High-Definition transcranial direct current stimulation (HD-tDCS) is well tolerated and safe in healthy adults

Turski

Kessler-Jones

Chow

et al. 2017

RNN

View full text Add to dashboard Cite

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“…New stimulation protocols using transcranial current are now being explored, raising new possibilities for cognitive enhancement as well as new questions regarding efficacy. High-definition tDCS, in which multiple small electrodes are used to create more focal current flow, may more effectively modulate cognitive abilities including WM (e.g., Nikolin, Loo, Bai, Dokos, & Martin, 2015). By varying current over time, with alternating current stimulation, random noise stimulation, and pulsed current stimulation, potentially different psychological effects may be obtained.…”

Section: Discussionmentioning

confidence: 99%

Does Transcranial Direct Current Stimulation Improve Healthy Working Memory?: A Meta-analytic Review

Mancuso

Ilieva

Hamilton

et al. 2016

Journal of Cognitive Neuroscience

247

179

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Transcranial direct current stimulation (tDCS) has been reported to improve working memory (WM) performance in healthy individuals, suggesting its value as a means of cognitive enhancement. However, recent meta-analyses concluded that tDCS has little or no effect on WM in healthy participants. In this article, we review reasons why these meta-analyses may have underestimated the effect of tDCS on WM and report a more comprehensive and arguably more sensitive meta-analysis. Consistent with our interest in enhancement, we focused on anodal stimulation. Thirty-one articles matched inclusion criteria and were included in four primary meta-analyses assessing the WM effects of anodal stimulation over the left and right dorsolateral pFC (DLPFC) and right parietal lobe as well as left DLPFC stimulation coupled with WM training. These analyses revealed a small but significant effect of left DLPFC stimulation coupled with WM training. Left DLPFC stimulation alone also enhanced WM performance, but the effect was reduced to nonsignificance after correction for publication bias. No other effects were significant, including a variety of tested moderators. Additional meta-analyses were undertaken with study selection criteria based on previous meta-analyses, to reassess the findings from these studies using the analytic methods of this study. These analyses revealed a mix of significant and nonsignificant small effects. We conclude that the primary WM enhancement potential of tDCS probably lies in its use during training. However, recent meta-analyses concluded that tDCS has little or no effect on WM in healthy participants.In this article, we review reasons why these meta-analyses may have underestimated the effect of tDCS on WM and report a more comprehensive and arguably more sensitive metaanalysis. Consistent with our interest in enhancement, we focused on anodal stimulation. Thirty-one articles matched inclusion criteria and were included in four primary meta-analyses assessing the WM effects of anodal stimulation over the left and right dorsolateral pFC (DLPFC) and right parietal lobe as well as left DLPFC stimulation coupled with WM training. These analyses revealed a small but significant effect of left DLPFC stimulation coupled with WM training. Left DLPFC stimulation alone also enhanced WM performance, but the effect was reduced to nonsignificance after correction for publication bias. No other effects were significant, including a variety of tested moderators. Additional meta-analyses were undertaken with study selection criteria based on previous meta-analyses, to reassess the findings from these studies using the analytic methods of this study. These analyses revealed a mix of significant and nonsignificant small effects. We conclude that the primary WM enhancement potential of tDCS probably lies in its use during training. ■

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“…However, recent research has addressed the ability of focal stimulation to achieve more refined targeting of neuromodulation5691033364849505152, because the increased focality of stimulation might improve the functional interpretation of stimulation effects, as the outcomes of brain stimulation are linked to the target area. Furthermore, once the target areas are determined, targeted neuromodulation might be paramount and avoid unwanted effects in other brain areas.…”

Section: Discussionmentioning

confidence: 99%

The Effect of a Transcranial Channel as a Skull/Brain Interface in High-Definition Transcranial Direct Current Stimulation—A Computational Study

Seo

Kim

Jun

2017

Sci Rep

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A transcranial channel is an interface between the skull and brain; it consists of a biocompatible and highly conductive material that helps convey the current induced by transcranial direct current stimulation (tDCS) to the target area. However, it has been proposed only conceptually, and there has been no concrete study of its efficacy. In this work, we conducted a computational investigation of this conceptual transcranial model with high-definition tDCS, inducing focalized neuromodulation to determine whether inclusion of a transcranial channel performs effectively. To do so, we constructed an anatomically realistic head model and compartmental pyramidal neuronal models. We analyzed membrane polarization by extracellular stimulation and found that the inclusion of a transcranial channel induced polarization at the target area 11 times greater than conventional HD-tDCS without the transcranial channel. Furthermore, the stimulation effect of the transcranial channel persisted up to approximately 80%, even when the stimulus electrodes were displaced approximately 5 mm from the target area. We investigated the efficacy of the transcranial channel and found that greatly improved stimulation intensity and focality may be achieved. Thus, the use of these channels may be promising for clinical treatment.

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Focalised stimulation using high definition transcranial direct current stimulation (HD-tDCS) to investigate declarative verbal learning and memory functioning

Cited by 138 publications

References 81 publications

Extended Multiple-Field High-Definition transcranial direct current stimulation (HD-tDCS) is well tolerated and safe in healthy adults

Extended Multiple-Field High-Definition transcranial direct current stimulation (HD-tDCS) is well tolerated and safe in healthy adults

Does Transcranial Direct Current Stimulation Improve Healthy Working Memory?: A Meta-analytic Review

The Effect of a Transcranial Channel as a Skull/Brain Interface in High-Definition Transcranial Direct Current Stimulation—A Computational Study

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