Focal Transplantation of Human iPSC-Derived Glial-Rich Neural Progenitors Improves Lifespan of ALS Mice

Kondo, Takayuki; Funayama, Misato; Tsukita, Kayoko; Hotta, Akitsu; Yasuda, Akimasa; Nori, Satoshi; Kaneko, Shinjiro; Nakamura, Masaya; Takahashi, Ryōsuke; Okano, Hideyuki; Yamanaka, Shinya; Inoue, Haruhisa

doi:10.1016/j.stemcr.2014.05.017

Cited by 130 publications

(99 citation statements)

References 29 publications

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“…Neural progenitor cells, which can be generated from iPSC, have become a promising source for cell therapy for ALS. These cells have been transplanted in the lumbar spinal cord in ALS mice models, further differentiated into neurons and astrocytes, and were shown to be able to improve the quality and lifespan of these mice [70,71] . Recently, the world has drawn attention to the ALS "Ice bucket" campaign [72] , gaining scientific research strength and raising public awareness about the disease.…”

Section: Alsmentioning

confidence: 99%

Induced pluripotent stem cells for modeling neurological disorders

Russo

Cugola

Fernandes

et al. 2015

WJT

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Section: Alsmentioning

confidence: 99%

Induced pluripotent stem cells for modeling neurological disorders

Russo

Cugola

Fernandes

et al. 2015

WJT

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“…Transplanted cells survived in the spinal cord and differentiated mainly into GFAP + , ALDH1L1 + , and GLT-1 + astrocytes. Analysis of NTFs expression at the lumbar spinal cord reveled upregulation in mouse-originated VEFF, NT3, and GDNF [152].…”

Section: Preclinical Studies Using Human Glial Progenitors Derived Frmentioning

confidence: 99%

Astrocytes in Pathogenesis of ALS Disease and Potential Translation into Clinic

Izrael¹,

Guy²,

Itskovitz‐Eldor³

et al. 2018

Astrocyte - Physiology and Pathology

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Astrocytes are the major cell population in the central nervous system (CNS) and play pivotal role in CNS homeostasis and functionality. Malfunction of astrocytes were implicated in multiple neurodegenerative diseases and disorders, including amyotrophic lateral sclerosis (ALS), spinal cord injury (SCI), brain stroke, Parkinson's disease (PD), and Alzheimer disease (AD). These new insights led to the rationale that transplantation of healthy and functional human astrocytes could support survival of neurons and be of therapeutic value in treating neurodegenerative diseases. Here, we will mainly focus on the role of astrocytes in ALS disease, the major cell sources for generation of human astrocytes, or astrocyte like cells and show how multiple preclinical studies demonstrate the efficacy of these cells in animal models. In addition, we will cover immerging early stage clinical trials that are currently being conducted using human astrocytes or human astrocyte like cell population.

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“…These transplanted cells show a good survival, differentiation potential, and also enhanced the life span of the treated animals (Kondo et al, 2014). Stem cell therapy has been an area of debate for a long time.…”

Section: Amyotrophic Lateral Sclerosis (Als)mentioning

confidence: 99%

Advances in Stem Cell Research- A Ray of Hope in Better Diagnosis and Prognosis in Neurodegenerative Diseases

Singh

Srivastav

Srivastava

et al. 2016

Front. Mol. Biosci.

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Neurodegeneration and neurodegenerative disorders have been a global health issue affecting the aging population worldwide. Recent advances in stem cell biology have changed the current face of neurodegenerative disease modeling, diagnosis, and transplantation therapeutics. Stem cells also serve the purpose of a simple in-vitro tool for screening therapeutic drugs and chemicals. We present the application of stem cells and induced pluripotent stem cells (iPSCs) in the field of neurodegeneration and address the issues of diagnosis, modeling, and therapeutic transplantation strategies for the most prevalent neurodegenerative disorders. We have discussed the progress made in the last decade and have largely focused on the various applications of stem cells in the neurodegenerative research arena.

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Focal Transplantation of Human iPSC-Derived Glial-Rich Neural Progenitors Improves Lifespan of ALS Mice

Cited by 130 publications

References 29 publications

Induced pluripotent stem cells for modeling neurological disorders

Induced pluripotent stem cells for modeling neurological disorders

Astrocytes in Pathogenesis of ALS Disease and Potential Translation into Clinic

Advances in Stem Cell Research- A Ray of Hope in Better Diagnosis and Prognosis in Neurodegenerative Diseases

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