Focal Segmental Glomerulosclerosis Followed by Granuloma and Preceding T-Cell Lymphoma by 46 Months: A Continuation Process or Coincidence

Abstract

Focal segmental glomerulosclerosis is a severe renal disease with a complex and unclear pathophysiology. Nephrotic syndrome is the clinical presentation of this renal disease. The recurrence of the disease after renal transplantation and the remission obtained after immune-adsorption treatment illustrate the implication of a circulating factor that requires characterization. Granulomatous inflammation is a tissue reaction caused by several conditions, including neoplastic diseases. In the literature, focal segmental glomerulosclerosis and granulomatous inflammation have both been associated with lymphoma. We report the case of a 56-year-old woman who initially developed focal and segmental glomerulosclerosis. After one year, the granulomatous inflammation was treated as tuberculosis infection and then as sarcoidosis. Finally, after another year, non-specified peripheral T-cell lymphoma was diagnosed.

Acute kidney injury in Hodgkin’s lymphoma, non-Hodgkin lymphoma/leukemia, and lymphoplasmacytic lymphoma: One center experience

“…We consider PGNMID, AL amyloidosis, MPGN, MN, FSGS, and IgAN, which totally presented in 13 cases, as NHL/CLL-related and HL-related causes of the underlying CKD, as all these variants of kidney damage were described in the NHL/CLL and HL setting. 3,6,16,[22][23][24][25][26][27][28][29] PGNMID and AL resulted from direct paraprotein deposition, while MPGN, MN, FSGS, and IgAN represent paraneoplastic spectrum. 24,25 AKI on the top of CKD in these 13 patients was pre-renal (9 cases), caused by LI (3 cases) and TLS (1 case).…”