Focal right temporo-occipital blood flow changes associated with judgment of line orientation

Hannay, H. Julia; Jc, Falgout; Da, Leli; Cr, Katholi; Jh, Halsey; El, Wills

doi:10.1016/0028-3932(87)90113-8

Cited by 32 publications

(20 citation statements)

References 31 publications

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“…We therefore examined the quantitative relationships between BOLD activation and behavioral performance on two visuospatial tasks in a fMRI experiment in order to determine the critical regions involved in task execution. Inspection of the coordinates of the activation foci revealed similar neural networks were involved in performance on both the line orientation and mental rotation tasks, consistent with previously published results (e.g., O'Donnell et al, 1997;Cohen et al, 1996;Perronet & Farrah, 1989;Hannay et al, 1987). When the physiological responses were correlated with RT data from the respective tasks, areas more specifically associated with performance on each task were identified.…”

Section: Discussionsupporting

confidence: 75%

“…For example, posterior parietal and extrastriate visual cortices are engaged in the mental rotation of objects as demonstrated by PET (Alivisatos & Petrides, 1997), fMRI (Cohen et al, 1996;Tagaris et al, 1996), and eventrelated potential (ERP) (Perronet & Farrah, 1989) techniques. However, they are also involved in performance on other visuospatial processing tasks such as those involving judgements of axis/line orientation (Taira, Kawashima, Inoue, & Fukuda, 1998;O'Donnell, Swearer, Smith, Hokama, & McCarly, 1997;Hannay et al, 1987;Benton, Varney, & Hamsher, 1978). Which of these two regions is specifically critical to performance on each of these rather different tasks remains an open question.…”

Section: Introductionmentioning

confidence: 99%

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Identifying Rate-Limiting Nodes in Large-Scale Cortical Networks for Visuospatial Processing: An Illustration using fMRI

Bullmore

Zubicaray

et al. 2001

Journal of Cognitive Neuroscience

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Abstract& With the advent of functional neuroimaging techniques, in particular functional magnetic resonance imaging (fMRI), we have gained greater insight into the neural correlates of visuospatial function. However, it may not always be easy to identify the cerebral regions most specifically associated with performance on a given task. One approach is to examine the quantitative relationships between regional activation and behavioral performance measures. In the present study, we investigated the functional neuroanatomy of two different visuospatial processing tasks, judgement of line orientation and mental rotation. Twenty-four normal participants were scanned with fMRI using blocked periodic designs for experimental task presentation. Accuracy and reaction time (RT) to each trial of both activation and baseline conditions in each experiment was recorded. Both experiments activated dorsal and ventral visual cortical areas as well as dorsolateral prefrontal cortex. More regionally specific associations with task performance were identified by estimating the association between (sinusoidal) power of functional response and mean RT to the activation condition; a permutation test based on spatial statistics was used for inference. There was significant behavioral±physiological association in right ventral extrastriate cortex for the line orientation task and in bilateral (predominantly right) superior parietal lobule for the mental rotation task. Comparable associations were not found between power of response and RT to the baseline conditions of the tasks. These data suggest that one region in a neurocognitive network may be most strongly associated with behavioral performance and this may be regarded as the computationally least efficient or rate-limiting node of the network. &

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Section: Discussionsupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Identifying Rate-Limiting Nodes in Large-Scale Cortical Networks for Visuospatial Processing: An Illustration using fMRI

Bullmore

Zubicaray

et al. 2001

Journal of Cognitive Neuroscience

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“…The cognitive deficits observed on the Judgment of Line Orientation, a task related mainly to right hemisphere functioning [31], are probably related to a right temporoparieto-occipital hypoperfusion as recently described in a single photon emission computed tomography (SPECT) study carried out on BD subjects without neurological involvement [32].…”

Section: Discussionmentioning

confidence: 98%

Cognitive impairment in Behçet's disease patients without overt neurological involvement

Monastero

Camarda

Pipia

et al. 2004

Journal of the Neurological Sciences

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“…What has been observed is that BLO performance correlates with increased blood flow (33Xe inhalation rCBF) bilaterally within the posterior brain regions (Hannay et al, 1987). Functional MRI (f MRI) research has shown that bilateral superior parietal lobe activation can be observed on a modified BLO task with a more dominant role attributed to the right parietal region.…”

Section: Imaging Correlates Of Visuospatial Tasksmentioning

confidence: 99%

Regional cerebral blood flow correlates of visuospatial tasks in Alzheimer's disease

Tippett

Black

2008

J Int Neuropsychol Soc

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This study investigated the role of visuospatial tasks in identifying cognitive decline in patients with Alzheimer's disease (AD), by correlating neuropsychological performance with cerebral perfusion measures. There were 157 participants: 29 neurologically healthy controls (age: 70.3 6 6.6, MMSE Ն 27), 86 patients with mild AD (age: 69.18 6 8.28, MMSE Ն 21) and 42 patients moderate0severe AD (age: 68.86 6 10.69, MMSE 8-20). Single Photon Emission Computerized Tomography (SPECT) was used to derive regional perfusion ratios, and correlated using partial least squares (PLS) with neuropsychological test scores from the Benton Line Orientation (BLO) and the Rey-Osterrieth Complex Figure (RO). Cross-sectional analysis demonstrated that mean scores differed in accordance with disease status: control group (BLO 25.5, RO 33.3); mild AD (BLO 20.1, RO 25.5); moderate0severe AD (BLO 10.7, RO 16). Correlations were observed between BLO0RO and right parietal SPECT regions in the AD groups. Visuospatial performance, often undersampled in cognitive batteries for AD, is clearly impaired even in mild AD and correlates with functional deficits as indexed by cerebral perfusion ratios on SPECT implicating right hemisphere circuits. Furthermore, PLS reveals that usual spatial tasks probe a distributed brain network in both hemispheres including many areas targeted by early AD pathology. (JINS, 2008(JINS, , 14, 1034(JINS, -1045

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Focal right temporo-occipital blood flow changes associated with judgment of line orientation

Cited by 32 publications

References 31 publications

Identifying Rate-Limiting Nodes in Large-Scale Cortical Networks for Visuospatial Processing: An Illustration using fMRI

Identifying Rate-Limiting Nodes in Large-Scale Cortical Networks for Visuospatial Processing: An Illustration using fMRI

Cognitive impairment in Behçet's disease patients without overt neurological involvement

Regional cerebral blood flow correlates of visuospatial tasks in Alzheimer's disease

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