Focal Relationship Between Structure and Function Within the Central 10 Degrees in Glaucoma

Abstract

The GCC is the most useful parameter to evaluate structure and function within the central 10° in glaucoma. Adjusting for RGC displacement is essential to evaluate the relationship between structure of the GCL-related layer and function at the central macula.

The relationship between central visual field sensitivity and macular ganglion cell/inner plexiform layer thickness in glaucoma

“…Our findings are in agreement with the previous studies which reported that adjusting the location of central VF test locations for RGC displacement improved the correlations for the four paracentral points although this improvement did not reach statistical significance 8 9. The reason for this location-dependent effect may be that the displacement of the macular GCs from the corresponding cones is maximal closest to the fovea 3 8 9. A previous study similarly reported that inferotemporal GC/IPL thickness had the highest correlation with corresponding sensitivities on microperimetry superotemporally 23.…”

“…These results are consistent with those of earlier studies, which found a severity-dependent association between macular structure and function in patients with glaucoma 9 24. Ohkubo et al 9 reported that GC/IPL thickness of most of the upper half of the macula did not significantly correlate with VF sensitivities in eyes with early glaucoma.…”

“…These results are consistent with those of earlier studies, which found a severity-dependent association between macular structure and function in patients with glaucoma 9 24. Ohkubo et al 9 reported that GC/IPL thickness of most of the upper half of the macula did not significantly correlate with VF sensitivities in eyes with early glaucoma. The reason for this severity-dependent association between macular structure and function is that the superior macular region is less susceptible to glaucomatous damage than the inferior macula in early disease 15.…”

“…Beyond the central 4.8×4.0 mm ellipse, where the GC/IPL measurements are provided by the proprietary software, the magnitude of such measurements is fairly small 3 17. A previous study reported that the correlation between VF sensitivity and GC/IPL thickness was often found to be in the wrong direction beyond 5.8° from the fovea 9. The results of our study need to be interpreted taking into account the topography of GCs in the human retina 3 16…”

Individual Differences in Foveal Shape: Feasibility of Individual Maps Between Structure and Function Within the Macular Region

“…For instance some authors reported that after considering this ''on average'' ganglion cell displacement in the macula, the sectorial structure-function relationship in glaucoma improves, 3,9 especially within the central 108 of the visual field. More recently, Turpin et al 10 have published a method for customizing such mapping based on an individual person's retinal ganglion cell plus inner plexiform layers (RGCþIPL) profiles obtained from macular OCT scans.…”