Focal photodynamic intracellular acidification as a cancer therapeutic

Gdovin, Matthew J.; Kadri, Nuha Buchanan; Rios, Lourdes; Holliday, Steven; Jordan, Zachary

doi:10.1016/j.semcancer.2017.02.005

Cited by 20 publications

(14 citation statements)

References 60 publications

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“…In the same line, and in order to increase the efficacy of targeted drug delivery systems with low toxicity, acridine orange, a photodynamic-related acidophilic dye with a strong tumoricidal action in different malignancies, takes advantage of the low extracellular pH of tumors [132,133]. Other photodynamic-oriented procedures have been recently reported as selective and local intracellular acidifiers in cancer treatment [134].…”

Section: Towards a New Perspective And Clinical Approach To Malignmentioning

confidence: 99%

Hydrogen Ion Dynamics of Cancer and a New Molecular, Biochemical and Metabolic Approach to the Etiopathogenesis and Treatment of Brain Malignancies

Harguindey¹,

Orozco²,

Alfarouk

et al. 2019

IJMS

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The treatment of cancer has been slowly but steadily progressing during the last fifty years. Some tumors with a high mortality in the past are curable nowadays. However, there is one striking exception: glioblastoma multiforme. No real breakthrough has been hitherto achieved with this tumor with ominous prognosis and very short survival. Glioblastomas, being highly glycolytic malignancies are strongly pH-dependent and driven by the sodium hydrogen exchanger 1 (NHE1) and other proton (H+) transporters. Therefore, this is one of those pathologies where the lessons recently learnt from the new pH-centered anticancer paradigm may soon bring a promising change to treatment. This contribution will discuss how the pH-centric molecular, biochemical and metabolic perspective may introduce some urgently needed and integral novel treatments. Such a prospective therapeutic approach for malignant brain tumors is developed here, either to be used alone or in combination with more standard therapies.

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Section: Towards a New Perspective And Clinical Approach To Malignmentioning

confidence: 99%

Hydrogen Ion Dynamics of Cancer and a New Molecular, Biochemical and Metabolic Approach to the Etiopathogenesis and Treatment of Brain Malignancies

Harguindey¹,

Orozco²,

Alfarouk

et al. 2019

IJMS

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“…pH variations are associated with different human diseases, like acidosis in tumor development 128 – 130 , and also in ischemic stroke, neurodegenerative disease, seizures, and respiratory control 131 , 132 . Indeed, pH modification can be envisaged as a therapeutic approach for these pathologies; for instance, non-invasive photodynamic therapy (PDT) has been shown to cause focal intracellular acidification in cancer cells 133 , 134 .…”

Section: Physiological Evidence and Compatibility With His Phosphorylmentioning

confidence: 99%

Histidine kinases and the missing phosphoproteome from prokaryotes to eukaryotes

Adam

Hunter

2018

Laboratory Investigation

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Protein phosphorylation is the most common type of post-translational modification in eukaryotes. The phosphoproteome is defined as the complete set of experimentally detectable phosphorylation sites present in a cell’s proteome under various conditions. However, we are still far from identifying all the phosphorylation sites in a cell mainly due to the lack of information about phosphorylation events involving residues other than Ser, Thr and Tyr. Four types of phosphate-protein linkage exist and these generate nine different phosphoresidues – pSer, pThr, pTyr, pHis, pLys, pArg, pAsp, pGlu, and pCys. Most of the effort in studying protein phosphorylation has been focused on Ser, Thr and Tyr phosphorylation. The recent development of 1- and 3-pHis monoclonal antibodies promises to increase our understanding of His phosphorylation and the kinases and phosphatases involved. Several His kinases are well defined in prokaryotes, especially those involved in Two-Component System (TCS) signaling. However in higher eukaryotes, NM23, a protein originally characterized as a nucleoside diphosphate kinase, is the only characterized protein-histidine kinase. This ubiquitous and conserved His kinase autophosphorylates its active site His, and transfers this phosphate either onto a nucleoside diphosphate or onto a protein His residue. Studies of NM23 protein targets using newly developed anti-pHis antibodies will surely help illuminate the elusive His phosphorylation-based signaling pathways. This review discusses the role that the NM23/NME/NDPK phosphotransferase plays, how the addition of the pHis phosphoproteome will expand the phosphoproteome, and make His phosphorylation part of the global phosphorylation world. It also summarizes why our understanding of phosphorylation is still largely restricted to the acid stable phosphoproteome, and highlights the study of NM23 histidine kinase as an entrée into the world of histidine phosphorylation.

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“…We would like to shed light on a recent breakthrough in oncology, first reported by Matthew Gdovin, in his research, published in Seminars of Clinical Biology, 2017 [ 1 ]. It was demonstrated that a chemical compound, Nitrobenzaldehyde, when injected into the tumor, prior to a beam of ultraviolet (UV) light, eliminated cancer cells from the body within two hours.…”

Section: Editorialmentioning

confidence: 99%

The Fight Against Cancer: Nitrobenzaldehyde as the Potential Warrior

Saleem

Iqbal

2018

Cureus

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New milestones have been reached in oncology with the advent of a noninvasive, photodynamic therapy which aims to eradicate cancer cells rapidly. A chemical compound, Nitrobenzaldehyde, injected into the tumor, activates by ultraviolet (UV) light and disrupts the cancer cells' internal and external dynamics. This technique could be of enormous therapeutic value in destroying numerous cancer lines including breast, prostate, pancreatic cancers, etc., without causing unwanted systemic side effects.

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Focal photodynamic intracellular acidification as a cancer therapeutic

Cited by 20 publications

References 60 publications

Hydrogen Ion Dynamics of Cancer and a New Molecular, Biochemical and Metabolic Approach to the Etiopathogenesis and Treatment of Brain Malignancies

Hydrogen Ion Dynamics of Cancer and a New Molecular, Biochemical and Metabolic Approach to the Etiopathogenesis and Treatment of Brain Malignancies

Histidine kinases and the missing phosphoproteome from prokaryotes to eukaryotes

The Fight Against Cancer: Nitrobenzaldehyde as the Potential Warrior

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