Focal pancreatic lesions: accuracy and complications of US-guided fine-needle aspiration cytology

Zamboni, Giulia; D’Onofrio, Mirko; Principe, Francesco; Mucelli, Roberto Pozzi

doi:10.1007/s00261-009-9527-6

Cited by 14 publications

(17 citation statements)

References 28 publications

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“…In agreement with other authors (Zamboni et al, 2010) at our institution , in the appropriate setting, percutaneous US-guided FNAB is considered the first invasive approach of obtaining tissue diagnosis confirmation in patients with unresectable lesions.…”

Section: Discussionmentioning

confidence: 54%

“…In a series of 545 US-guided FNAB, 93,4% procedures were diagnostic, with an overall 99,4% sensitivity and 99.4% accuracy (Zamboni et al, 2010).…”

Section: Type Of Needle and Results Of Guided Biopsymentioning

confidence: 99%

“…However, as recently reported, local expertise in and the availability of EUS and interventional radiology may determine the first procedure selected for a cytohistological diagnosis for a pancreatic mass (Zamboni et al, 2010 ). …”

Section: Guide For Pancreatic Biopsymentioning

confidence: 99%

“…In addiction CT fluoroscopy allows visualizing the needle track from the entry point to the target, allowing faster and more efficient procedure (Zamboni et al, 2010).…”

Section: Computed Tomographymentioning

confidence: 99%

“…Patients with suspected pancreatic cancer and imaging studies suggesting resectable tumour should undergo directly to surgery since no histologic diagnosis confirmation is required prior to surgical exploration unless neoadjuvant therapy is indicated (Zamboni et al, 2010).…”

Section: Diagnosis Of Pancreatic Neoplasiamentioning

confidence: 99%

See 4 more Smart Citations

Role of Guided - Fine Needle Biopsy of the Pancreatic Lesion

Cavanna¹,

Cicilia²,

Nobili³

et al. 2012

Pancreatic Cancer - Clinical Management

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Section: Discussionmentioning

confidence: 54%

“…In a series of 545 US-guided FNAB, 93,4% procedures were diagnostic, with an overall 99,4% sensitivity and 99.4% accuracy (Zamboni et al, 2010).…”

Section: Type Of Needle and Results Of Guided Biopsymentioning

confidence: 99%

Section: Guide For Pancreatic Biopsymentioning

confidence: 99%

“…In addiction CT fluoroscopy allows visualizing the needle track from the entry point to the target, allowing faster and more efficient procedure (Zamboni et al, 2010).…”

Section: Computed Tomographymentioning

confidence: 99%

Section: Diagnosis Of Pancreatic Neoplasiamentioning

confidence: 99%

See 3 more Smart Citations

Role of Guided - Fine Needle Biopsy of the Pancreatic Lesion

Cavanna¹,

Cicilia²,

Nobili³

et al. 2012

Pancreatic Cancer - Clinical Management

View full text Add to dashboard Cite

Cytologic features of pancreatic adenocarcinoma with “vacuolated cell pattern.” report of a case diagnosed by endoscopic ultrasound‐guided fine‐needle aspiration

Samad

Conway

Attam

et al. 2014

Diagnostic Cytopathology

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The "vacuolated cell pattern" has only been recently described as a distinct morphologic variant of pancreatobiliary adenocarcinoma. Herein, we report the endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) cytologic features of a case of pancreatic adenocarcinoma with "vacuolated cell pattern" occurring in a 60-year-old man. The aspirate smears and cell block sections from the EUS-FNA of a 23.5 mm hypoechoic pancreatic head mass were highly cellular, showing variably-sized crowded three-dimensional cell clusters, flat sheets, and numerous highly atypical single cells. The background was bloody and showed necrotic debris, but no discernible mucus. The most striking feature of the aspirate was the presence of numerous very large (20-50 µm) vacuoles, occupying the entire cytoplasm, pushing the nuclei to the side and indenting them, that imparted a cribriform appearance to the sheets of neoplastic cells. The non-vacuolated neoplastic cells were large, had abundant dense (squamoid) cytoplasm, irregularly contoured hyperchromatic nuclei, and prominent macronucleoli. Histologic evaluation of the pancreatectomy specimen showed a "vacuolated cell pattern" adenocarcinoma composed of poorly formed glands, solid sheets, and infiltrating single cells with pleomorphic nuclei and large cytoplasmic vacuoles. To our knowledge, this is the first report describing the cytologic features of this rather uncommon morphologic variant of pancreatic adenocarcinoma. Recognition of this morphologic variant of pancreatic adenocarcinoma in ESU-FNA samples allows its differentiation from primary and metastatic signet-ring cell carcinomas.

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Pancreatic Ultrasound: State of the Art

Ciaravino

D’Onofrio

2019

J of Ultrasound Medicine

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An ultrasound (US) study is often the first imaging approach in patients with abdominal symptoms or signs related to abdominal diseases, and it is often part of the routine workup. The pancreatic gland, despite its retroperitoneal site, can be efficiently examined with US thanks to advances in US technologies. Nowadays, a pancreatic US study could be considered complete if multiparametric, including the use of Doppler imaging, US elastography, and contrast‐enhanced imaging for the study of a pancreatic mass. A complete US examination could contribute to a faster diagnosis, especially if the pancreatic lesion is incidentally detected, addressing second‐step imaging modalities correctly.

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Focal pancreatic lesions: accuracy and complications of US-guided fine-needle aspiration cytology

Abstract: Tissue confirmation of the diagnosis is required either for unresectable pancreatic masses or for resectable masses when the diagnosis is uncertain. In this article, we review indications, technique, and clinical results of percutaneous fine-needle aspiration of focal pancreatic lesions.

Cited by 14 publications

References 28 publications

Role of Guided - Fine Needle Biopsy of the Pancreatic Lesion

Role of Guided - Fine Needle Biopsy of the Pancreatic Lesion

Cytologic features of pancreatic adenocarcinoma with “vacuolated cell pattern.” report of a case diagnosed by endoscopic ultrasound‐guided fine‐needle aspiration

Pancreatic Ultrasound: State of the Art

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