Focal onset non-motor seizure following COVID-19 vaccination: A mere coincidence?

Ghosh, Ritwik; Dubey, Souvik; Roy, Dipayan; Mandal, Arpan; Naga, Dinabandhu; Benito‐León, Julián

doi:10.1016/j.dsx.2021.05.003

Cited by 29 publications

(28 citation statements)

References 5 publications

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“…At the initial submission of this article, there were no known reports of possible COVID-19 vaccination-related seizures. However, since then, one report has surfaced of a 68-year-old rural Indian man experiencing non-epileptic seizures four days after receiving his first dose of Covishield vaccine [5]. We are therefore the second report, to our knowledge, suggesting this possibility.…”

Section: Discussionmentioning

confidence: 69%

Two Cases of Post-Moderna COVID-19 Vaccine Encephalopathy Associated With Nonconvulsive Status Epilepticus

Liu¹,

Ugolini²,

Jha³

2021

Cureus

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Coronavirus disease 2019 (COVID-19) infections can cause many complications, including central nervous system (CNS) complications. One of the most common COVID-19 CNS complications is COVID-19 encephalopathy, a disorder characterized by cognitive impairment, altered consciousness, and even seizures. The Moderna COVID-19 vaccine is a recently approved mRNA-based vaccine aimed at preventing COVID-19 infections and their complications. Here, we describe two patients with no known neurological or psychiatric history who presented with encephalopathy and seizures that began after part one of their Moderna COVID-19 vaccine series. To our knowledge, there are no other reports of post-Moderna COVID-19 vaccine encephalopathy in the literature. We suggest a mechanism for this complication and thoroughly discuss why the Moderna vaccine is possibly responsible, by addressing confounders in our patients.

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Section: Discussionmentioning

confidence: 69%

Two Cases of Post-Moderna COVID-19 Vaccine Encephalopathy Associated With Nonconvulsive Status Epilepticus

Liu¹,

Ugolini²,

Jha³

2021

Cureus

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“…Previous studies of COVID-19 vaccine acceptance, including those among cancer patients and also the general population, revealed similar attitudes [ 6 , 22 , 32 , 33 ].…”

Section: Discussionmentioning

confidence: 82%

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology Clinic of University Clinical Hospital Mostar, Bosnia and Herzegovina: A Cross-Sectional Study

et al. 2021

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Background The pandemic of Coronavirus infectious disease 2019 (COVID-19) poses a major public health challenge, and an effective vaccine is the potential mechanism to resolve this specific situation. The present study aimed to evaluate acceptance of COVID-19 vaccination among patients attending the Oncology Clinic of University Clinical Hospital Mostar. Material/Methods This cross-sectional observational study enrolled 364 patients with cancer from the Oncology Clinic of University Clinical Hospital Mostar during February 2021. Data were collected using a questionnaire that captured general information about the participants and their attitudes toward COVID-19 vaccination. Results Of the participants, 41.8% answered “Yes” when asked if they would take the vaccine once it becomes available, 37.6% answered “Not sure”, and 20.6% answered “No”. For patients in favor of vaccination, the main reasons reported were fear of getting sick (77.6%), the desire to contribute to herd immunity (57.8%), and trusting the recommendations of health professionals (57.2%). The main reasons for the patients’ vaccination refusal/indecision were doubts about the results from clinical trials of COVID-19 vaccines (49.1%), concerns about adverse effects (24.5%), and confusion about the various vaccine options (19.8%). The majority of participants (82.4%) stated that recommendation by their oncologist could influence their decision about vaccination. Of the participants who indicated unwillingness (refusal or indecision) to be vaccinated against COVID-19, 65.3% stated that recommendation by their oncologist could influence their decision about vaccination. Conclusions The findings from the present study showed most patients had refused or were indecisive regarding immunization with COVID-19 vaccine. Increasing physician awareness of this situation may result in higher rates of vaccination.

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“…A case report from India stated that a healthy older male had a first-ever seizure following the first dose of the vaccine. 15 Investigations after the event showed normal electroencephalography for age, but ASM was started, as mild periventricular leukoaraiosis was seen on brain magnetic resonance imaging. No further seizure was reported at the subsequent 1-month follow-up.…”

Section: Resultsmentioning

confidence: 99%

“…Interestingly, one healthy control reported a seizurelike event with no fever or other provoking factors and another one was diagnosed with reflex epilepsy after vaccination. A case report from India stated that a healthy older male had a first‐ever seizure following the first dose of the vaccine 15 . Investigations after the event showed normal electroencephalography for age, but ASM was started, as mild periventricular leukoaraiosis was seen on brain magnetic resonance imaging.…”

Section: Discussionmentioning

confidence: 99%

COVID‐19 vaccine take‐up rate and safety in adults with epilepsy: Data from a multicenter study in China

Zhang

Xiao

et al. 2021

Epilepsia

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SummaryObjectiveThis study was undertaken to investigate the COVID‐19 vaccine uptake rate and possible postvaccination effects in adults with epilepsy.MethodsWe invited adults with epilepsy attending three centers in China from July 24 to August 31, 2021 to participate in this study. We also asked age‐ and sex‐matched controls among people attending for other chronic neuropsychiatric conditions and healthy controls accompanying people with illness attending the hospitals to participate. We excluded people who, under the national guidelines, had evident contradictions to vaccination. Participants were interviewed face‐to‐face using questionnaires. Vaccine uptake and postvaccine adverse events among the people with epilepsy were compared with those with neuropsychiatric conditions and controls. We also compared the willingness and reasons for hesitancy among unvaccinated participants.ResultsWe enrolled 981 people, of whom 491 had epilepsy, 217 had other neuropsychiatric conditions, and 273 were controls. Forty‐two percent of those with epilepsy had had the first dose of a vaccine, compared with 93% of controls and 84% of the people with neuropsychiatric conditions (p < .0001). The majority (93.8%) of those immunized had inactivated vaccines. Among the unvaccinated people with epilepsy, 59.6% were willing to have the vaccine. Their main reasons for hesitation were potential adverse effects (53.3%) and concerns about losing seizure control (47.0%). The incidence of adverse events in the epilepsy group was similar to controls. Nineteen people with epilepsy reported an increase in seizure frequency. No episode of status epilepticus or prolonged seizures was reported. Two controls had their first‐ever seizure, which was unlikely related to the vaccine.SignificanceThe vaccine uptake rate in people with epilepsy was lower than in their same‐age controls. The postvaccination effect was no higher than in controls. We found no evidence suggesting worsening seizures after vaccination. Measurement and education focused on increasing the vaccination rate in epilepsy are warranted.

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Focal onset non-motor seizure following COVID-19 vaccination: A mere coincidence?

Cited by 29 publications

References 5 publications

Two Cases of Post-Moderna COVID-19 Vaccine Encephalopathy Associated With Nonconvulsive Status Epilepticus

Two Cases of Post-Moderna COVID-19 Vaccine Encephalopathy Associated With Nonconvulsive Status Epilepticus

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology Clinic of University Clinical Hospital Mostar, Bosnia and Herzegovina: A Cross-Sectional Study

COVID‐19 vaccine take‐up rate and safety in adults with epilepsy: Data from a multicenter study in China

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