Focal nodular hyperplasia of the liver as established by 99mTc sulfur colloid and HIDA scintigraphy.

Biersack, H. J.; Thelen, M.; Torres, Julián Francisco Ruiz; Lackner, Klaus-Jürgen; Winkler, C

doi:10.1148/radiology.137.1.7422844

Cited by 27 publications

(11 citation statements)

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“…However, contrary to expectations, several studies showed that 30–36% of FNH have decreased uptake [32,64,65]. Herman et al [66] used the 99m Tc-sulfur-colloid scan preoperatively for the diagnosis of FNH (n = 13) and HCA (n = 10).…”

Section: Resultsmentioning

confidence: 99%

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Imaging Modalities for Focal Nodular Hyperplasia and Hepatocellular Adenoma

Esschert¹,

Gulik²,

Phoa

2010

Dig Surg

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Background/Aims: There are several imaging modalities available for the detection of focal liver lesions. Differentiation between focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) is important because of the consequences for management. However, differentiation based on imaging alone still shows limitations. Methods: We reviewed the literature for typical features of FNH and HCA on radiologic and nuclear imaging with emphasis on differentiation of both lesions. Results: Seven articles describe the performance of an imaging modality for the differentiation between FNH and HCA. Limitations of these studies are the small sample size and/or the lack of comparison with the ‘gold standard’, i.e. histological diagnosis. No studies are available that compare the accuracy of several imaging modalities in the differentiation of FNH and HCA. Conventional ultrasound (US) is not useful in the differentiation because of the non-specific features. On contrast-enhanced US, the arterial filling direction of FNH is centrifugal and centripetal in case of HCA. The parenchymal enhancement of FNH is sustained in the portal venous and delayed phases, but shows rapid washout in case of HCA. Multiphase CT scan can differentiate FNH from HCA when there is a central scar. FNH may have a slightly higher relative enhancement in the arterial phase. On MRI with hepatocyte-specific contrast agents, HCA does not show contrast uptake in the hepatobiliary phase in contrast to FNH. Conclusion: We conclude that there is limited evidence of the diagnostic performance of currently used imaging modalities for the differentiation of FNH and HCA. We therefore propose a prospective study (DiFA trial) to determine the accuracy of several radiologic and nuclear imaging studies in differentiating FNH and HCA.

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Section: Resultsmentioning

confidence: 99%

“…The hepatobiliary tracer 99m Tc-mebrofenin (HIDA) is, like the hepatobiliary MR contrast agents, taken up by functional hepatocytes and excreted into the bile [64]. Since biliary drainage in FNH is reduced compared to normal liver parenchyma, the tracer is retained and visible as a hot spot on delayed images [65].…”

Section: Resultsmentioning

confidence: 99%

Imaging Modalities for Focal Nodular Hyperplasia and Hepatocellular Adenoma

Esschert¹,

Gulik²,

Phoa

2010

Dig Surg

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“…The lesion may be either isodense or hypodense [4]. However, according to a recent report, as many as 44% of nine tumors were undetectable on the basis of tissue attenuation differentials, and the detection of the lesion was not improved by the use of intravenous contrast material [26].…”

Section: Discussionmentioning

confidence: 99%

Focal nodular hyperplasia of the liver imaging by differing modalities

et al. 1983

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The logistic approach in diagnosis of focal nodular hyperplasia (FNH) of the liver is discussed, based on the experience with three children. In only one child could the diagnosis be made without angiography. In that child the combination of hypervascularity on the radionuclide angiogram and uptake of the radiocolloid by Kupffer cells was sufficient for the diagnosis of FNH. If the radionuclide scintigraphy is inconclusive, angiography has to be done to show the typical features of FNH, seen in all three patients. Only if scintigraphy and angiography are not able to differentiate FNH from hepatic adenoma, biopsy or exploratory laparotomy is indicated as a final diagnostic procedure. Ultrasonography or computerized tomography is of value only in screening for hepatic mass lesions.

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“…Der Fokus liegt dabei auf der Positronenemissionstomografie in Kombination mit der Computertomografie (PET/CT). Die hepatobiliäre Funktionsszintigrafie unter Verwendung von 99m Technetium markierten Imino-diacetat-Verbindungen, welche auch zur Charakterisierung verschiedener Lebertumore dienen kann [11], liegt außerhalb des Fokus dieser Arbeit. Diesbezüglich wurde jedoch insbesondere in den letzten Jahren der Stellenwert zur Beurteilung der Leberfunktion im Rahmen der Radioembolisation primärer und sekundärer Lebertumore gezeigt [12,13,14].…”

Section: Introductionunclassified

Primäre und sekundäre Lebertumore – aus Sicht der Nuklearmedizin

Holzgreve,

Ilhan,

Unterrainer

et al. 2023

Angewandte Nuklearmedizin

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ZusammenfassungKonventionelle, radiologische Modalitäten wie die Ultraschalldiagnostik, CT- und MRT-Bildgebung sind der klinische Standard in der onkologischen Bildgebung primärer und sekundärer Lebertumore. In den letzten Jahrzehnten konnten nuklearmedizinische Verfahren, darunter insbesondere die PET/CT-Bildgebung, zusätzliche, molekulare Informationen liefern, die maßgeblich zur weiteren Optimierung der Stadieneinteilung und Risikostratifizierung beigetragen haben. Neben FDG als „Standard“-Radiopharmakon der PET/CT-Bildgebung werden in diesem Artikel weitere, spezifischere Radiopharmaka und neue Entwicklungen beschrieben.

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Focal nodular hyperplasia of the liver as established by 99mTc sulfur colloid and HIDA scintigraphy.

Abstract: Three cases of focal nodular hyperplasia of the liver are reported, presumably associated with the long-term use of oral contraceptives. Special reference is made to hepatobiliary scintigraphy with 99mTc diethyl-IDA, and the cause of the observed findings is discussed.

Cited by 27 publications

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Imaging Modalities for Focal Nodular Hyperplasia and Hepatocellular Adenoma

Imaging Modalities for Focal Nodular Hyperplasia and Hepatocellular Adenoma

Focal nodular hyperplasia of the liver imaging by differing modalities

Primäre und sekundäre Lebertumore – aus Sicht der Nuklearmedizin

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