Focal nodular hyperplasia and hepatic adenoma: A Review

Lizardi-Cervera, Javier; Cuéllar-Gamboa, Lorena; Motola-Kuba, Daniel

doi:10.1016/s1665-2681(19)32013-7

Cited by 47 publications

(30 citation statements)

References 12 publications

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“…Occasionally, two or more tumors are found. Tumor size is variable, with a range of 1–30 cm (usually 8–15 cm) 16 . In our study, 93.7% of the Chinese patients were diagnosed with a solitary lesion.…”

Section: Discussionmentioning

confidence: 60%

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Systematic review of hepatocellular adenoma in China and other regions

Lin

Esschert

Liu

et al. 2010

J of Gastro and Hepatol

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Hepatocellular adenoma (HCA) is a benign liver neoplasm with a risk of spontaneous bleeding and malignant transformation. The aim of this review article is to review all the case reports and case series of patients with HCA from 1998 to 2008 in China and other parts of the world in order to compare clinical presentation, surgical management and outcomes. A search for all reports of HCA in the world literature from 1998 to 2008 was performed. A total of 356 patients were identified, including 191 patients from China, 104 from Europe, 46 from North America, and 15 from South-East Asia. A female predominance was not observed in Chinese patients in contrast to the other regions. Acute/chronic abdominal pain was the main clinical presentation in all regions. Twenty patients were diagnosed with coexistent hepatocellular carcinoma (HCC), and hepatitis B virus infection (HBV) was found among six of them. The management of HCA consisted of resection in most cases. The clinical presentation of HCA in China differed from other parts of the world regarding male predominance and a higher incidence of coexistent HCC in China. This might be the result of the birth control policy in China, limited oral contraceptive use, and the higher incidence of HBV.

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Section: Discussionmentioning

confidence: 60%

“…Tumor size is variable, with a range of 1-30 cm (usually 8-15 cm). 16 In our study, 93.7% of the Chinese patients were diagnosed with a solitary lesion. In patients from South-East Asia and North America, the rate of solitary lesions was 80% and 65.2%, respectively.…”

Section: Clinical Presentationmentioning

confidence: 56%

Systematic review of hepatocellular adenoma in China and other regions

Lin

Esschert

Liu

et al. 2010

J of Gastro and Hepatol

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“…Both lesions are typically asymptomatic and are often discovered incidentally on imaging (1–2). HA is strongly associated with exposure to estrogens, particularly estrogen-containing oral contraceptives.…”

Section: Introductionmentioning

confidence: 99%

Characterization of hepatic adenoma and focal nodular hyperplasia with gadoxetic acid

Mohajer

Frydrychowicz

Robbins

et al. 2012

Magnetic Resonance Imaging

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Purpose-To characterize imaging features of histologically proven hepatic adenoma (HA) as well as histologically and/or radiologically proven focal nodular hyperplasia (FNH) using delayed hepatobiliary MR imaging with 0.05mmol/kg gadoxetic acid. Materials and Methods-Five patients with sixHAs with histological correlation were retrospectively identified on liver MRI studies performed with gadoxetic acid, and T1-weighted imaging acquired during the delayed hepatobiliary phase. Additionally, 23 patients with 34 radiologically diagnosed FNH lesions (interpreted without consideration of delayed imaging) were identified, two of which also had histological confirmation. Signal intensity ratios relative to adjacent liver were measured on selected imaging sequences.Results-All six hepatic adenomas (100%), which had histological confirmation, demonstrated hypointensity relative to adjacent liver on delayed imaging. Further, all of the FNH (including 34 radiologically proven, 2 of which were also histologically proven) were either hyperintense (23/34, 68%) or isointense (11/34, 32%) relative to the adjacent liver on delayed imaging. None of the FNHs were hypointense relative to liver.Conclusion-Distinct imaging characteristics of HA versus FNH on delayed gadoxetic acidenhanced MRI, with adenomas being hypointense and FNH being iso-or hyperintense on delayed imaging may improve specificity for characterization, and aid in the differentiation of these two lesions.

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“…Focal nodular hyperplasia (FNH) is the second commonest benign liver tumour and occurs in 3% of adults . Over 80–90% of lesions occur in females in the reproductive years . A solitary nodule is present in 78% of cases with 84% having a diameter of around 5 cm, although some have been reported up to 15 cm .…”

Section: Specific Liver Massesmentioning

confidence: 99%

Diagnosis and management of liver masses in pregnancy

Milburn

Black

Ahmed

et al. 2016

The Obstetric & Gynaecologis

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Key content Liver masses are increasingly detected in pregnancy because of the widespread use of abdominal ultrasonography. Most lesions are benign and can be treated conservatively, although rarely these can lead to clinical symptoms and the potential for significant haemorrhage. Diagnosis of liver masses is made primarily through radiological assessment with blood tests and rarely by direct liver biopsy. Collaboration between the obstetric department and specialist liver multidisciplinary team is essential to ensure optimal management. Learning objectives Review of liver masses in pregnancy. Overview of issues relevant in the prepregnancy and postpartum periods. Interventional management strategies for liver lesions. Ethical issues Should the diagnosis of a liver mass lead to termination of pregnancy? When should ionising radiation be used to aid diagnosis of liver masses? Are doctors aware of the risk of bleeding from a benign liver mass?

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Focal nodular hyperplasia and hepatic adenoma: A Review

Cited by 47 publications

References 12 publications

Systematic review of hepatocellular adenoma in China and other regions

Systematic review of hepatocellular adenoma in China and other regions

Characterization of hepatic adenoma and focal nodular hyperplasia with gadoxetic acid

Diagnosis and management of liver masses in pregnancy

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