Focal liver lesions: MR imaging with Mn-DPDP--initial clinical results in 40 patients.

Hamm, Bernd; Vogl, Thomas J.; Branding, Gordian; Schnell, B.; Taupitz, Matthias; Wolf, K.-J.; Lissner, J.

doi:10.1148/radiology.182.1.1309218

Cited by 170 publications

(47 citation statements)

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“…The sensitivity achieved by current MRI technology is essentially equivalent to that of helical CT for larger HCCs, especially when state-of-the-art liver MRI protocols including dynamic contrast-enhanced acquisitions are adopted [29][30][31]. In addition, paramagnetic hepatocytespecific contrast agents are showing promise in their ability to improve detection of HCC [32,33]. However, despite substantial technological improvements in MRI and CT over the past decade, detection of small (less than 2 cm) HCCs still remains a significant challenge [34].…”

Section: Hepatocellular Carcinomamentioning

confidence: 99%

The role of contrast-enhanced ultrasound in the detection of focal liver leasions

et al. 2001

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IntroductionOver the last decade, the therapeutic approach for treating focal liver malignancies, including both hepatocellular carcinoma (HCC) and metastatic lesions, has changed dramatically, particularly due to the proliferation of new treatment strategies. These have included percutaneous ablative therapies such as percutaneous ethanol injection (PEI), thermal therapies such as radiofrequency (RF), laser, and microwaves, as well as angiographic therapies such as segmental chemoembolization and hypoxic perfusion, and orthotopic liver transplantation (OLT). Furthermore, at the same time, there has been a general greater acceptance of previously characterized, more standard treatment modalities such as surgical resection and systemic chemotherapy. Given this wide range of potential therapeutic options, a main aim of current medical management of focal liver cancer is to tailor therapy for every patient by selecting the therapeutic modality which will ideally provide the highest success rate, fewest risks and lowest costs for each given situation. However, in order to provide this level of optimized, individualized care, accurate detection of neoplastic lesions by imaging modalities including ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MRI) is mandatory.Worldwide, US is the most widely available imaging modality for the screening of liver pathology, and has furthermore functioned as the mainstay for screening efforts for the detection of small incidental hepatomas in high-risk patients. Nevertheless, the limitations of conventional gray-scale B-mode US for the detection of focal liver lesions have been well documented [1,2]. Color Doppler and power Doppler increased the sensitivity for hepatic lesion detection compared to grayscale US, but they did not allow levels of sensitivity comparable to those of contrast enhanced axial imaging (CT and MRI). Two breakthroughs in US, harmonic imaging and the development of second-generation contrast agents, have recently been described and have demonstrated the potential to dramatically broaden the scope of US diagnosis of hepatic lesions. This paper will review the prior state of the art for the sonographic detection of the two most common forms of focal liver neoplasia (HCC and metastases), and illustrate the potential of the newer techniques for improving the sensitivity of US . Historical review of conventional ultrasonography Hepatocellular carcinomasThe detection rate of HCC using US is related to the size, location, and echotexture of the lesions, as well as to both the US technology employed and operator experience. Nevertheless, due to successive technologic improvements, there has been a trend toward detecting ever smaller lesions. Given a wide range of techniques and technology, the reported detection rate of HCCs measuring less than 2 cm in diameter has been variable, ranging from 46% to 95% [1, 3, 4], with accurate detection of 82-93% of HCCs measuring between 2 and 3 cm. For HCCs smaller than 1 cm, US is reported to have a detecti...

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Section: Hepatocellular Carcinomamentioning

confidence: 99%

The role of contrast-enhanced ultrasound in the detection of focal liver leasions

et al. 2001

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“…Following intravenous administration, the Mn-DPDP chelate dissociates slowly, and the manganese is taken up by the hepatocytes. This leads to an increase in signal intensity of normal liver parenchyma on the T1-weighted image caused by T1 shortening and, thereby, to an increase in contrast between normal and abnormal tissue (13,16). Because there are no liver-specific CT contrast agents available, it would seem that Mn-DPDP-enhanced MR imaging might allow a more specific diagnosis to be established for focal liver lesions than dualphase spiral CT.…”

Section: Gastrointestinal Imagingmentioning

confidence: 99%

Characterization of Liver Lesions with Mangafodipir Trisodium–enhanced MR Imaging: Multicenter Study Comparing MR and Dual-Phase Spiral CT

Oudkerk¹,

Torres²,

Song³

et al. 2002

Radiology

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“…As the agent is taken up by the functioning hepatocytes, increased contrast between normal liver parenchyma and different kinds of hepatic tumors can be achieved (1). Since a hepatocellular lesion and a group of liver metastases from endocrine tumors may show uptake of the agent at various degrees (2)(3)(4), some differential diagnostic information on tumor origin can also be obtained.…”

mentioning

confidence: 99%

Sequence optimization in mangafodipir trisodium-enhanced liver and pancreas MRI

Wang

Johansson

Western³

et al. 1999

J. Magn. Reson. Imaging

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Focal liver lesions: MR imaging with Mn-DPDP--initial clinical results in 40 patients.

Cited by 170 publications

References 0 publications

The role of contrast-enhanced ultrasound in the detection of focal liver leasions

The role of contrast-enhanced ultrasound in the detection of focal liver leasions

Characterization of Liver Lesions with Mangafodipir Trisodium–enhanced MR Imaging: Multicenter Study Comparing MR and Dual-Phase Spiral CT

Sequence optimization in mangafodipir trisodium-enhanced liver and pancreas MRI

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