Focal Liver Lesions Classification and Characterization

Calistri, Linda; Castellani, A.; Matteuzzi, Benedetta; Mazzoni, Elisa; Pradella, Silvia; Colagrande, Stefano

doi:10.1097/rct.0000000000000458

Cited by 13 publications

(12 citation statements)

References 31 publications

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“…Due to its contrast independence, ADC could be more advantageous over contrast‐enhanced MRI in differentiating between benign and malignant liver lesions . However, ADC alone may not be adequate for characterization of focal liver lesions . Indeed, previously the usefulness of concomitant use of multiple MRI metrics, including volumetric DWI and volumetric contrast‐enhanced MRI, has been demonstrated in predicting response to treatment and prognosis of patients with HCC, cholangiocarcinoma, and neuroendocrine liver metastasis …”

Section: Discussionmentioning

confidence: 99%

“…26 However, ADC alone may not be adequate for characterization of focal liver lesions. 34 Indeed, previously the usefulness of concomitant use of multiple MRI metrics, including volumetric DWI and volumetric contrast-enhanced MRI, has been demonstrated in predicting response to treatment and prognosis of patients with HCC, 10 cholangiocarcinoma, 35 and neuroendocrine liver metastasis. 26 In the present study, we used both volumetric contrast-enhanced MRI and volumetric analysis of ADC in distinguishing HCC, FNH, and HCA from each other.…”

Section: Discussionmentioning

confidence: 99%

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Utility of volumetric contrast‐enhanced and diffusion‐weighted MRI in differentiating between common primary hypervascular liver tumors

Zarghampour

Fouladi

Pandey

et al. 2018

Magnetic Resonance Imaging

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Utility of volumetric contrast‐enhanced and diffusion‐weighted MRI in differentiating between common primary hypervascular liver tumors

Zarghampour

Fouladi

Pandey

et al. 2018

Magnetic Resonance Imaging

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“…Diffusion‐weighted imaging (DWI) has been widely applied in the liver . In the Liver Imaging Reporting and Data System (LI‐RADS) v. 2017, the presence of restricted diffusion was an ancillary feature favoring malignancy and the target appearance on DWI was characteristic of category LR‐M (probable or definite malignancy, not specific for HCC, eg, IMCC)…”

mentioning

confidence: 99%

Volumetric Apparent Diffusion Coefficient Histogram Analysis in Differentiating Intrahepatic Mass‐Forming Cholangiocarcinoma From Hepatocellular Carcinoma

Zou

Luo

et al. 2018

Magnetic Resonance Imaging

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Background: Accurate differentiation between intrahepatic mass-forming cholangiocarcinoma (IMCC) and hepatocellular carcinoma (HCC) is needed because treatment and prognosis differ significantly. Purpose: To explore whether volumetric apparent diffusion coefficient (ADC) histogram analysis can provide additional value to dynamic enhanced MRI in differentiating IMCC from HCC. Study Type: Retrospective. Population: In all, 131 patients with pathologically proven IMCC (n = 33) or HCC (n = 98). Field Strength/Sequence: 3.0T MRI/conventional T 1 -weighted imaging (T 1 WI), T 2 WI, and diffusion-weighted imaging (DWI) with b value of 800 sec/mm 2 , dynamic enhanced MRI with gadobenate dimeglumine. Assessment: Dynamic enhanced MR images were analyzed by two independent reviewers using a five-point scale to determine the diagnosis. Volumetric ADC assessments were performed independently by two radiologists to obtain different histogram parameters for each lesion. Quantitative histogram parameters were compared between the IMCC group and HCC group. Diagnostic performance of dynamic enhanced MRI, volumetric ADC histogram analysis, and the combination of both were analyzed. Statistical Tests: Intraclass correlation coefficient (ICC) analysis, independent Student's t-test, or Mann-Whitney U-test, receiver operator characteristic (ROC) curves analysis, and McNemar test. Results: The sensitivity and specificity for dynamic enhanced MRI to differentiate IMCC from HCC were 82.1% and 82.6%, respectively. For all volumetric ADC histogram parameters, the 75th percentile ADC (ADC 75% ) had the highest AUC (0.791) in differentiating IMCC from HCC, with sensitivity and specificity of 69.7% and 77.6%, respectively. When combining dynamic enhanced MRI with ADC 75% , the sensitivity and specificity were 82.1% and 91.9%, respectively. Compared to dynamic enhanced MRI alone, the specificity for combined dynamic enhanced MRI and ADC 75% was significantly increased (P = 0.008). Data Conclusion: Volumetric ADC histogram analysis provides additional value to dynamic enhanced MRI in differentiating IMCC from HCC. Level of Evidence: 3 Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2019;49:975-983. View this article online at wileyonlinelibrary.com.

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“…6 е (Fig. 6 f трастного препарата [32]. В случае нечеткой визуализации очагов на Т1-ВИ и Т2-ВИ, при ДВИ подобные образования имели более высокую интенсивность сигнала и более четкие контуры [33].…”

Section: компьютерная томографияunclassified

Radiological Methods in Diagnostics of Focal Liver Lesions

Schekoturov¹,

Bakhtiozin²,

Серова³

et al. 2018

Rejr

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ель исследования. Особое место среди заболеваний печени занимают различные опухоли и опухолеподобные поражения. За последние годы, благодаря внедрению в клиническую практику более совершенной диагностической аппаратуры и достаточно широкому применению различных контрастных препаратов при исследованиях брюшной полости с помощью ультразвукового метода (УЗИ), мультиспиральной компьютерной томографии (МСКТ) и магнитно-резонансной томографии (МРТ) значительно повысились возможности диагностики различных очаговых поражений печени. Кроме того, упростилась дифференциальная диагностика доброкачественных и злокачественных новообразований, в том числе, при размерах очагов менее 1 см. В данном научном обзоре описаны возможности как «рутинного» метода исследования печени-УЗИ, так и новейших методик, которые внедряются в современную практику, таких как УЗИ с внутривенным контрастированием, УЗИ эластография и перфузионная КТ и МРТ. Представлены преимущества каждого из методов, а также ограничения их применения в клинической практике.

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Focal Liver Lesions Classification and Characterization

Abstract: Diffusion-weighted imaging may improve classification/characterization of FLLs at unenhanced/enhanced examinations.

Cited by 13 publications

References 31 publications

Utility of volumetric contrast‐enhanced and diffusion‐weighted MRI in differentiating between common primary hypervascular liver tumors

Utility of volumetric contrast‐enhanced and diffusion‐weighted MRI in differentiating between common primary hypervascular liver tumors

Volumetric Apparent Diffusion Coefficient Histogram Analysis in Differentiating Intrahepatic Mass‐Forming Cholangiocarcinoma From Hepatocellular Carcinoma

Radiological Methods in Diagnostics of Focal Liver Lesions

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