Focal Laser Ablation for Prostate Cancer Followed by Radical Prostatectomy: Validation of Focal Therapy and Imaging Accuracy

Lindner, Uri; Lawrentschuk, Nathan; Weersink, Robert A.; Davidson, Sean M.; Raz, Orit E.; Hlasny, Eugen; Langer, Deanna L.; Gertner, Mark R.; Kwast, Theodorus H. van der; Haider, Masoom A.; Trachtenberg, John

doi:10.1016/j.eururo.2010.03.008

Cited by 157 publications

(114 citation statements)

References 11 publications

Supporting

Mentioning

111

Contrasting

Order By: Relevance

“…Preclinical trials using 980 nm diode laser (Visualase, Houston, Texas) as a thermal energy source for in-bore focal ablation have shown precise, accurate and predictable ablation zones [20,47,48]. Two separate phase I trials using the transperineal approach, on a cohort of 38 patients [49] and nine patients [50], respectively, have demonstrated its feasibility in humans with minimal or no sideeffects of the treatment.…”

Section: Magnetic Resonance-guided Focal Laser Ablationmentioning

confidence: 98%

In-bore MRI interventions

Ghai

Trachtenberg²

2015

Current Opinion in Urology

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Magnetic Resonance-guided Focal Laser Ablationmentioning

confidence: 98%

In-bore MRI interventions

Ghai

Trachtenberg²

2015

Current Opinion in Urology

Self Cite

View full text Add to dashboard Cite

show abstract

“…A variety of treatment modalities have been used to deliver focal prostate cancer therapy. The literature includes reports on high-intensitye focused ultrasound (HIFU) (7,8), cryotherapy (9e14), laser ablation (15,16), and photodynamic therapy (17), but there are limited reports on focal high-dose-rate (HDR) or lowdose-rate (LDR) prostate brachytherapy.…”

Section: Introductionmentioning

confidence: 99%

Focal high-dose-rate brachytherapy: A dosimetric comparison of hemigland vs. conventional whole-gland treatment

et al. 2013

View full text Add to dashboard Cite

PURPOSE: To determine the utility of focal high-dose-rate brachytherapy for localized prostate cancer, we investigated the impact on target coverage and dose to organs at risk (OARs) with hemigland (HG) compared with whole-gland (WG) treatment. METHODS AND MATERIALS:A total of 10 WG implants were used to generate 10 WG and 20 HG (left and right) treatment plans optimized with the inverse planning simulation annealing algorithm using Oncentra MasterPlan (Nucletron B.V., Veenendaal, The Netherlands). The standard distribution of 17e18 catheters designed for WG was used to generate HG plans. The same OARs namely bladder, rectum, and urethra contours and dose constraints were applied for HG and WG plans. The HG contour was a modification of the WG contour whereby the urethra divided the prostate into HGs.

show abstract

“…This poses a challenge to FT evaluation as there is currently no validated PSA threshold that would be considered fulfillment of the oncological aspect of the trifecta. After lesion-targeted FT and even hemiablation, most of the gland remains vital, 45,46 hence the PSA does not reach undetectable levels. New standards of treatment efficacy would have to be implemented.…”

Section: Evaluation Of Treatment Efficacymentioning

confidence: 99%

“…39 Histopathologic analysis of radical prostatectomy specimens initially treated with FLA has validated treatment efficacy, revealing homogeneous coagulative necrosis of the target volume with no remaining viable cells. 45 Later, the same group performed fully MR-guided and monitored FLA in two patients without complication. Two weeks post-treatment contrast-enhanced MR imaging revealed devascularization of the target with no evidence of residual disease, damage to the rectum, or damage to the neurovascular bundles.…”

Section: Dovepressmentioning

confidence: 99%

The new era of minimally invasive interventions for prostate cancer: robot-assisted laparoscopic radical prostatectomy and focal therapy

Schatloff¹,

Louis²,

Lindner³

2011

OAS

Self Cite

View full text Add to dashboard Cite

Prostate cancer remains a common but highly treatable disease. Innovations in prostate cancer treatment have allowed a transition toward minimally invasive approaches in an attempt to avoid treatment-related morbidities. In the middle of the treatment spectrum between radical open surgeries and active surveillance lies robot-assisted laparoscopic radical prostatectomy (RALP) and focal therapy (FT). This review sets out the most current information on RALP and FT (including laser ablation, cryotherapy, high-intensity focused ultrasound, photodynamic therapy, and irreversible electroporation).

show abstract

Focal Laser Ablation for Prostate Cancer Followed by Radical Prostatectomy: Validation of Focal Therapy and Imaging Accuracy

Cited by 157 publications

References 11 publications

In-bore MRI interventions

In-bore MRI interventions

Focal high-dose-rate brachytherapy: A dosimetric comparison of hemigland vs. conventional whole-gland treatment

The new era of minimally invasive interventions for prostate cancer: robot-assisted laparoscopic radical prostatectomy and focal therapy

Contact Info

Product

Resources

About