Focal intrahepatic extramedullary hematopoiesis: color Doppler US and CT findings

Aytaç, Suat; Fítöz, Suat; Akyar, Serdar; Atasoy, Çetin; Erekul, Selim

doi:10.1007/s002619900515

Cited by 21 publications

(7 citation statements)

References 8 publications

(20 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The liver is fixed posteriorly and superiorly by the coronary ligament, hypoattenuating at unenhanced CT with a welldefined edge and does not enhance after the intravenous administration of contrast material (Fig 7). These characteristics could be related to a high grade of intralesional fibrosis (14). Extramedullary hematopoiesis may involve the subcapsular region of the liver based on the progression of disease, similar to involvement of the subcapsular region of the liver by lymphoma.…”

Section: Invasion Via the Perihepatic Ligaments-mentioning

confidence: 96%

Hepatic Capsular and Subcapsular Pathologic Conditions: Demonstration with CT and MR Imaging

Lee¹,

Kim²,

Kwack³

et al. 2008

RadioGraphics

View full text Add to dashboard Cite

A variety of pathologic conditions and pseudolesions occur at the capsular and subcapsular regions of the liver and are detected with cross-sectional abdominal imaging. These entities are related to anatomic and hemodynamic characteristics of the liver such as negative subdiaphragmatic pressure, connection with other viscera and extraperitoneal sites by the perihepatic ligaments, and a "third inflow" of blood from sources other than the usual hepatic arterial and portal venous sources. Pathologic conditions can affect the hepatic capsular and subcapsular regions by way of peritoneal, hematogenous, biliary, and perihepatic ligamentous routes. Pseudolesions or benign conditions may also be identified on the basis of altered hemodynamics of the liver. Computed tomography and magnetic resonance imaging with a multiphasic approach can be used to identify and characterize these entities. Familiarity with the wide spectrum of pathologic conditions and pseudolesions at the hepatic capsular and subcapsular regions and precise knowledge of the anatomic and hemodynamic characteristics of the liver will aid the radiologist in diagnosing pathologic conditions and differentiating pseudolesions from true lesions.

show abstract

Section: Invasion Via the Perihepatic Ligaments-mentioning

confidence: 96%

Hepatic Capsular and Subcapsular Pathologic Conditions: Demonstration with CT and MR Imaging

Lee¹,

Kim²,

Kwack³

et al. 2008

RadioGraphics

View full text Add to dashboard Cite

show abstract

“…Iron overload is frequent in congenital haemolytic anaemias and is usually related to chronic transfusion [4]. Although unusual, focal intra-hepatic EMH in this setting can mimic other solid lesions of the liver leading to a troublesome differential diagnosis with hepatocellular carcinoma (HCC) [5, 6]. To our knowledge the specific MR features of intra-hepatic EMH have been reported in just four separated case reports [1, 5, 7, 8].…”

Section: Introductionmentioning

confidence: 99%

MRI features of intrahepatic extramedullary haematopoiesis in sickle cell anaemia

Jelali

Luciani

Kobeiter³

et al. 2006

Cancer Imaging

View full text Add to dashboard Cite

Extramedullary haematopoiesis (EMH) is a reactive mechanism by which blood cells are produced outside of the bone marrow to supplement insufficient production or increased destruction of erythrocytes. EMH is uncommon in sickle cell anaemia (SCA). We report the first case of focal intra-hepatic EMH in SCA depicted on MRI occurring in a 32-year-old woman with homozygote SCA and in view of previously published data, highlight the diagnostic features suggesting a differential diagnosis with other focal liver lesions including infectious, inflammatory or primary liver tumors.

show abstract

“…Extramedullary hematopoiesis (EMH) is a compensatory mechanism by which blood cells are produced outside the bone marrow when marrow production is unable to maintain the needs of the organism (1). It can be seen in a variety of hematological disorders that lack cell formation such as myeloproliferative diseases.…”

mentioning

confidence: 99%

“…It can be seen in a variety of hematological disorders that lack cell formation such as myeloproliferative diseases. EMH usually shows microscopic involvement and its most common sites are the liver, spleen, and lymph nodes (1, 2). In rare cases, such as presented in this report, the involvement can manifest as a mass-like lesion; this uncommon manifestation made it difficult for us to differentiate this disease entity from other focal hepatic neoplasms.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Intrahepatic Extramedullary Hematopoiesis Mimicking a Hypervascular Hepatic Neoplasm on Dynamic- and SPIO-Enhanced MRI

Lee

Kim

et al. 2008

Korean J Radiol

View full text Add to dashboard Cite

We present a rare case of a focal intrahepatic extramedullary hematopoiesis (EMH) that mimicked a hypervascular hepatic neoplasm in a 33-year-old woman with idiopathic myelofibrosis. The lesion showed homogeneous and persistent enhancement on both contrast-enhanced CT and gadolinium-enhanced dynamic MR imaging. The lesion did not demonstrate an apparent signal drop on a T2*-weighted sequence following administration of a superparamagnetic iron-oxide agent (SHU 555A). A hepatocellular adenoma was the initial radiological diagnosis. To the best of our knowledge, this is the first report of a histopathologically proven intrahepatic EMH evaluated with dynamic- and SPIO-enhanced MRI.

show abstract

Focal intrahepatic extramedullary hematopoiesis: color Doppler US and CT findings

Cited by 21 publications

References 8 publications

Hepatic Capsular and Subcapsular Pathologic Conditions: Demonstration with CT and MR Imaging

Hepatic Capsular and Subcapsular Pathologic Conditions: Demonstration with CT and MR Imaging

MRI features of intrahepatic extramedullary haematopoiesis in sickle cell anaemia

Intrahepatic Extramedullary Hematopoiesis Mimicking a Hypervascular Hepatic Neoplasm on Dynamic- and SPIO-Enhanced MRI

Contact Info

Product

Resources

About