Focal Hyperhidrosis

Naumann, Markus; Hofmann, U.; Bergmann, Ilka; Hamm, Henning; Toyka, Klaus V.; Reiners, Karlheinz

doi:10.1001/archderm.134.3.301

Cited by 219 publications

(26 citation statements)

References 12 publications

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“…Our results confirm the efficacy of treatment of palmar hyperhidrosis with injections of botulinum toxin [7, 8, 9, 10, 11, 12, 13, 14, 15]. However, a review of the literature indicates that there is so far no consensus on the way to use botulinum toxin for palmar hyperhidrosis.…”

Section: Discussionsupporting

confidence: 77%

“…Although the results of these observations need to be confirmed by standardized studies, they suggest that intracutaneous/subcutaneous injections are not complicated by a higher incidence of muscle weakness than subepidermal injections. This is in contrast with the incidence of hematomas, which were not noted after subepidermal injections and occurred in series using subcutaneous injections at incidence rates ranging from 9 to 25% [7, 11]. …”

Section: Discussionmentioning

confidence: 96%

“…All patients were severely disabled by social or occupational consequences of excessive sweating. Before and every month after the botulinum toxin injections, the area of hyperhidrosis was visualized by the semiquantitative iodine-starch test, as previously reported [11]. In this test, an iodine solution (2 g of iodine in 10 ml of castor oil and alcohol to 100 ml) is painted over the palms.…”

Section: Methodsmentioning

confidence: 99%

“…It helps in a variety of conditions including blepharospasm, strabismus, focal dystonias, spasmodic dysphonia, achalasia and has been recently used as a successful treatment of localized hyperhidrosis [3, 4, 5, 6]. Recent studies have reported that injections of botulinum toxin represent an effective therapeutic option for idiopathic palmar hyperhidrosis [7, 8, 9, 10, 11, 12, 13, 14, 15]. However, there is so far no consensus on the way to administer botulinum toxin for palmar hyperhidrosis.…”

Section: Introductionmentioning

confidence: 99%

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Treatment of Idiopathic Palmar Hyperhidrosis with Botulinum Toxin

Vadoud-Seyedi

Heenen²,

Simonart³

2001

Dermatology

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Background: Botulinum toxin represents a novel therapeutic option for idiopathic palmar hyperhidrosis. However, so far there is no consensus on the way to administer botulinum toxin in this indication. Moreover, its use is limited by severe pain during the injections, especially with subepidermal injections close to ‘free nerve endings’. Objectives: To analyze the effectiveness and tolerability of intracutaneous injections of botulinum toxin after nerve blocks and to review the techniques of injections and the results reported by other groups. Methods: Twenty-three adult patients with refractory palmar hyperhidrosis were treated with intracutaneous injections of botulinum toxin after ulnar and median nerve blocks. Patients were followed up on a monthly basis. Results: In all patients botulinum toxin abolished sweating in the injected areas within 1 week. Anhidrosis lasted for 4–13 months. The intensity of pain was rated as absent (n = 13), mild (n = 8) or moderate (n = 2). Other side effects included hematoma (n = 2) and pain consecutive to nerve block (n = 1). Discussion: Intracutaneous injections of botulinum toxin after median and ulnar nerve block represent an effective and mildly painful technique to treat palmar hyperhidrosis and may be as safe as subepidermal injections.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 96%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Treatment of Idiopathic Palmar Hyperhidrosis with Botulinum Toxin

Vadoud-Seyedi

Heenen²,

Simonart³

2001

Dermatology

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show abstract

“…Surgical procedures are performed in severely affected patients. Intra- or subcutaneous injections of botulinum toxin are a novel, effective and safe alternative therapeutic modality in the management of focal hyperhidrosis [1, 2, 3, 4, 5, 6]. Its benefits may last as long as 14 months [1, 2].…”

Section: Introductionmentioning

confidence: 99%