Focal epilepsy impacts rapid eye movement sleep microstructure

Schiller, Katharina; Ellenrieder, Nicolás von; Avigdor, Tamir; Kosseifi, Charbel El; Abdallah, Chifaou; Minato, Erica; Gotman, Jean; Frauscher, Birgit

doi:10.1093/sleep/zsac250

Cited by 7 publications

(3 citation statements)

References 41 publications

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“…The rates and duration of sawtooth waves are reduced in patients with both temporal and extratemporal lobe epilepsy. 67,68 6 | SLEEP, WAKE, AND EPILEPTOGENESIS So far, we have reported what has been observed in patients and animals with epilepsy. Because epilepsy is essentially a dynamic process-the phenotypic traits, including the comorbidities, may evolve during aging-it is possible that the relationships between sleep and epilepsy may also change over time.…”

Section: Oscillations Affected In Patients With Epilepsy?mentioning

confidence: 97%

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Sleep, oscillations, and epilepsy

et al. 2023

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Sleep and wake are defined through physiological and behavioral criteria and can be typically separated into non‐rapid eye movement (NREM) sleep stages N1, N2, and N3, rapid eye movement (REM) sleep, and wake. Sleep and wake states are not homogenous in time. Their properties vary during the night and day cycle. Given that brain activity changes as a function of NREM, REM, and wake during the night and day cycle, are seizures more likely to occur during NREM, REM, or wake at a specific time? More generally, what is the relationship between sleep–wake cycles and epilepsy? We will review specific examples from clinical data and results from experimental models, focusing on the diversity and heterogeneity of these relationships. We will use a top‐down approach, starting with the general architecture of sleep, followed by oscillatory activities, and ending with ionic correlates selected for illustrative purposes, with respect to seizures and interictal spikes. The picture that emerges is that of complexity; sleep disruption and pathological epileptic activities emerge from reorganized circuits. That different circuit alterations can occur across patients and models may explain why sleep alterations and the timing of seizures during the sleep–wake cycle are patient‐specific.

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Section: Oscillations Affected In Patients With Epilepsy?mentioning

confidence: 97%

“…Data on REM sleep remain sparse. The rates and duration of sawtooth waves are reduced in patients with both temporal and extratemporal lobe epilepsy 67,68 …”

Section: How Are Sleep Oscillations Affected In Patients With Epilepsy?mentioning

confidence: 99%

Sleep, oscillations, and epilepsy

et al. 2023

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“…Epilepsy is well known to lead to alterations in sleep. Patients with epilepsy (PWE) tend to have less efficient sleep with increased fragmentation, prolonged sleep latency, 1 and notably shorter rapid eye movement (REM) sleep compared to healthy controls 2,3 . Although sleep deprivation can be a clear trigger for seizures, increased epileptiform activity itself can disrupt sleep via arousals 4 .…”

Section: Introductionmentioning

confidence: 99%

Sleep physiology in patients with epilepsy: Influence of seizures on rapid eye movement (REM) latency and REM duration

Kilgore‐Gomez,

Norato,

Theodore

et al. 2024

Epilepsia

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ObjectiveA well‐established bidirectional relationship exists between sleep and epilepsy. Patients with epilepsy tend to have less efficient sleep and shorter rapid eye movement (REM) sleep. Seizures are far more likely to arise from sleep transitions and non‐REM sleep compared to REM sleep. Delay in REM onset or reduction in REM duration may have reciprocal interactions with seizure occurrence. Greater insight into the relationship between REM sleep and seizure occurrence is essential to our understanding of circadian patterns and predictability of seizure activity. We assessed a cohort of adults undergoing evaluation of drug‐resistant epilepsy to examine whether REM sleep prior to or following seizures is delayed in latency or reduced in quantity.MethodsWe used a spectrogram‐guided approach to review the video‐electroencephalograms of patients' epilepsy monitoring unit admissions for sleep scoring to determine sleep variables.ResultsIn our cohort of patients, we found group‐ and individual‐level delay of REM latency and reduced REM duration when patients experienced a seizure before the primary sleep period (PSP) of interest or during the PSP of interest. A significant increase in REM latency and decrease in REM quantity were observed on nights where a seizure occurred within 4 h of sleep onset. No change in REM variables was found when investigating seizures that occurred the day after the PSP of interest. Our study is the first to provide insight about a perisleep period, which we defined as 4‐h periods before and after the PSP.SignificanceOur results demonstrate a significant relationship between seizures occurring prior to the PSP, during the PSP, and in the 4‐h perisleep period and a delay in REM latency. These findings have implications for developing a biomarker of seizure detection as well as longer term seizure risk monitoring.

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The Relationship Between Sleep, Epilepsy, and Development: a Review

Roliz

Kothare

2023

Curr Neurol Neurosci Rep

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Focal epilepsy impacts rapid eye movement sleep microstructure

Cited by 7 publications

References 41 publications

Sleep, oscillations, and epilepsy

Sleep, oscillations, and epilepsy

Sleep physiology in patients with epilepsy: Influence of seizures on rapid eye movement (REM) latency and REM duration

The Relationship Between Sleep, Epilepsy, and Development: a Review

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