Focal Endothelial Cell Injury in Rabbit Aorta, Aggravation of Injury by 2 Days of Cholesterol Feeding

Svendsen, Einar

doi:10.1111/j.1699-0463.1979.tb00032.x

Cited by 8 publications

(5 citation statements)

References 23 publications

(18 reference statements)

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“…The cells were seen to be curled up at some locations and they also became elevated and swollen. Also in studies of the effects of dietarily-induced hypercholesterolaemia, endothelial cell swelling has been taken as sign of injury (Bylock et al 1977, Svendsen 1979.…”

Section: Discussionmentioning

confidence: 99%

Early Reactions of the Arterial Wall, Following Mechanical Trauma

Bylock

Bondjers

1981

Acta Pathologica Microbiologica Scandinavica Section A Patholog

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Bylock, A. & Bondjers, G. Early reactions of the arterial wall, following mechanical trauma. A scanning and transmission electron microscopy study. Acta path. microbiol. scand. Sect. A, 89: 3 I3-323, 1981.Endothelial injury has for a long time been suggested to be an important factor for the development of atherosclerotic lesions. In this study, a superficial, circumferential, injury to the aortic intima was induced via a catheter covered with small stones, introduced into the femoral artery of rabbits. The immediate amwer of the -rial wall and the formed elements of the blood was studied with combined scanning and transmission electron microscopy. De-endothelialization was noted and the denuded areas were almost immediately covered by platelets, spreading over the surface and releasing the contents of their granules by time. At some locations deeper injuries to the elastic laminae of the wall could be noted. Especially frequent around these areas, but also common all over the de-endothelialized surface, leukocytes were seen. Both neutrophils, lymphocytes and monocytes could be found. A demarcation of the border of the injury was noted three days after catheterization.

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Section: Discussionmentioning

confidence: 99%

Early Reactions of the Arterial Wall, Following Mechanical Trauma

Bylock

Bondjers

1981

Acta Pathologica Microbiologica Scandinavica Section A Patholog

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“…Results obtained by Svendsen & Tindall ( 1 3) with arterial casts during continuous monitoring of the diameter Endothelial cell injury is commonly found at the lower lip of intercostal anery ostia (I 5. 16). This area merges with the smooth area downstream to the ostia.…”

Section: Discussionmentioning

confidence: 99%

Pattern of Intimal Folds Around Intercostal Artery Orifices in Rabbit Aorta

Svendsen

1980

Acta Pathologica Microbiologica Scandinavica Section A Patholog

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The pattern of intimal folds was studied around intercostal artery orifices in rabbit aorta by scanning electron microscopy and light microscopy. The area just proximal and distal to the orifices revealed a smooth surface lacking folds, reflected by a stretched internal elastic membrane which showed no undulation. Lateral as well as further proximal and distal well‐preserved folds were observed. It is reasonable to suppose that the pattern of intimal folds in this area reflects the special flow conditions prevailing in and at the intercostal artery orifices.

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“…This fact may indicate that the atherosclerotic process starts in the ICA-area. Experimentally the ICA-area is a site of increased permeablility (161, platelet deposition (9, I I), and endothelial cell injury (27,28,29). Increased cell replication atherosclerosis are described in the same area (2, 1 5 , 2 1, 22).…”

Section: Discussionmentioning

confidence: 99%

Distribution of Atherosclerosis in Human Descending Thoracic Aorta

Svendsen

Eide

1980

Acta Pathologica Microbiologica Scandinavica Section A Patholog

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A morphometric study of 49 randomly selected human aortas is reported with regard to the distribution of atherosclerotic lesions in the descending thoracic aorta (DTA). The intercostal artery area (ICA‐area) revealed a higher degree of atherosclerosis compared with the remaining part of the DTA. The difference was more striking at overall lower grades of atherosclerosis of the DTA. The ventral aspect of the DTA in the proximal and caudal thirds showed a higher degree of atherosclerosis compared with the middle third. The atherosclerotic indices of the proximal and distal areas correlated significantly with increasing heart weights but not for the middle third. The explanation of this is, presumably, irregular flow conditions. For the distal part a possible effect of continuous pounding of an enlarged heart upon the ventral aspect of the descending thoracic aorta is discussed.

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Focal Endothelial Cell Injury in Rabbit Aorta, Aggravation of Injury by 2 Days of Cholesterol Feeding

Cited by 8 publications

References 23 publications

Early Reactions of the Arterial Wall, Following Mechanical Trauma

Early Reactions of the Arterial Wall, Following Mechanical Trauma

Pattern of Intimal Folds Around Intercostal Artery Orifices in Rabbit Aorta

Distribution of Atherosclerosis in Human Descending Thoracic Aorta

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