Focal electroretinograms and fundus appearance in nonexudative age-related macular degeneration

Falsini, Benedetto; Serrao, Sebastiano; Fadda, Antonello; Iarossi, Giancarlo; Porrello, Giovanni; Cocco, F; Merendino, E.

doi:10.1007/s004170050218

Cited by 38 publications

(31 citation statements)

References 22 publications

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“…Another study confirmed these findings and is postulated to be due outer retinal ischaemia [27]. Normal fERG phase but decreasing amplitudes have been documented with increasing severity of non-exudative AMD [28].…”

Section: Focal Ergmentioning

confidence: 61%

The electroretinogram: a useful tool for evaluating age-related macular disease?

et al. 2010

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With an ageing population, the number of age-related macular disease (ARMD) cases will inevitably rise. This gives greater impetus for the need to identify the disease earlier and assess treatments to slow disease progression. Differing electroretinogram (ERG) modalities have been reviewed in relation to the objective assessment of retinal function in ARMD and for monitoring the effectiveness of clinical interventions. Conflicting results have been found with regard to the efficacy of ERG findings in the investigation of ARMD in previous years. The newer multifocal ERG paradigm provides spatial topographical information about retinal function in ARMD. It has shown promising results in monitoring effectiveness of clinical interventions and studies are continuing in this area. Better knowledge of retinal function in ARMD may lead to enhanced treatments at each phase of the disease.

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Section: Focal Ergmentioning

confidence: 61%

The electroretinogram: a useful tool for evaluating age-related macular disease?

et al. 2010

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“…Stereo fundus color photography (30°) was evaluated by two experienced observers, to determine the ARM grading. Digital image analysis was performed according to a published, semi-automated, quantitative protocol [25] to estimate the proportion of retinal area affected by drusen or RPE defects, reflected by angiographic abnormal hyperfluorescence. The analysis was performed for the C and PC areas, matched with those of the FERG and perimetric stimuli.…”

Section: Fundus Lesion Assessmentmentioning

confidence: 99%

“…FERG responses to sinusoidal flicker stimuli have been employed to characterize regional cone-mediated dysfunction in retinitis pigmentosa [23] and in eyes recovering from retinal detachment surgery [24] . The FERG to sinusoidal flicker may provide a unique way to assess directly temporal retinal responsiveness, which has been found to be altered in ARM by both FERG [5,25] and psychophysical [10,26] techniques. In addition, the FERG responses have been shown to be highly sensitive in very early stages of disease [5,19,25,27,28] , and potentially useful to monitor its progression [28,29] .…”

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confidence: 99%

“…The FERG to sinusoidal flicker may provide a unique way to assess directly temporal retinal responsiveness, which has been found to be altered in ARM by both FERG [5,25] and psychophysical [10,26] techniques. In addition, the FERG responses have been shown to be highly sensitive in very early stages of disease [5,19,25,27,28] , and potentially useful to monitor its progression [28,29] . Finally, in a previous study in retinitis pigmentosa [23] , FERG losses recorded at the C and PC retinal regions significantly predicted perimetric losses at corresponding locations.…”

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confidence: 99%

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Regional Cone-Mediated Dysfunction in Age-Related Maculopathy Evaluated by Focal Electroretinograms: Relationship with Retinal Morphology and Perimetric Sensitivity

et al. 2009

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Purpose: To assess regional cone-mediated function in age-related maculopathy (ARM) by focal electroretinograms (FERGs), and to compare FERGs with morphologic changes and perimetric sensitivity at corresponding locations. Methods: Twenty-six ARM patients and 12 age-matched controls were evaluated. FERGs were elicited by either a central (0–2.25°, C) or a paracentral annular (2.25–9°, PC) flickering (41 Hz) field, presented on a light-adapting background. Morphological changes (soft drusen and/or retinal pigment epithelium defects) at matched locations were assessed by fundus photography and fluorescein angiography. Perimetric sensitivity was measured by Octopus 10° program (tM2). Results: When compared to controls, mean C and PC FERG amplitudes of patients were reduced (p < 0.01), and the mean PC FERG phase was delayed (p < 0.01). Both FERG delays and morphologic lesions tended to involve to a greater extent the PC compared to the C region. In the C region, perimetric losses were correlated with the extent of morphologic lesions (p < 0.05). In the PC region, perimetric losses were correlated with FERG amplitudes (p < 0.05). Conclusions: In ARM, FERG losses are eccentricity-dependent, not quantitatively linked to retinal morphology, and correlated with perimetric losses, suggesting a heterogeneous dysfunction with loss of both C and PC perimetric sensitivities.

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“…Drusen are associated with slight delays in mfERG implicit times, although changes are not limited to areas with drusen (Berrow et al, 2010). Correlations between the amplitude of the focal ERG and severity of non-exudative AMD have been reported (Falsini et al, 1999). A focal ERG implementation of the photo stress test also found a significantly slower recovery of bleach cone response in ARM patients (Binns, & Margrain 2007).…”

Section: Introductionmentioning

confidence: 98%

Electroretinogram Assessment of Dark Adaptation and Rod Phototransduction from the Central Retina of Japanese Macaques with Dominantly Inherited Drusen

Jeffrey¹,

Morgans²,

Duvoisin³

et al. 2011

Electroretinograms

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Focal electroretinograms and fundus appearance in nonexudative age-related macular degeneration

Abstract: The results indicate that, in NE-AMD, the FERG is altered in parallel with the extent and severity of fundus lesions. However, a functional impairment of outer macular layers, which is detected by FERG losses, could precede morphological changes typical of more advanced disease.

Cited by 38 publications

References 22 publications

The electroretinogram: a useful tool for evaluating age-related macular disease?

The electroretinogram: a useful tool for evaluating age-related macular disease?

Regional Cone-Mediated Dysfunction in Age-Related Maculopathy Evaluated by Focal Electroretinograms: Relationship with Retinal Morphology and Perimetric Sensitivity

Electroretinogram Assessment of Dark Adaptation and Rod Phototransduction from the Central Retina of Japanese Macaques with Dominantly Inherited Drusen

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