Focal cortical hypoperfusion in corticobasal degeneration demonstrated by three-dimensional surface display with 123 I-IMP: a possible cause of apraxia

Okuda, Bungo; Tachibana, Hisao; Takeda, Masanaka; Kawabata, Keita; Sugita, Minoru; Fukuchi, Minora

doi:10.1007/s002340050168

Cited by 3 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This type of limb clumsiness follows perirolandic cortical damage, suggesting a disorder of sensorimotor integration. 11,16,17,[28][29][30] In fact, all of our patients showed greater clumsiness on the side contralateral to the more hypoperfused SM and PP. In addition to limb-kinetic apraxia, our patients presented occasionally with perseveration or body parts as objects in pantomime.…”

Section: Discussionmentioning

confidence: 45%

Cerebral Blood Flow Correlates of Higher Brain Dysfunctions in Corticobasal Degeneration

Okuda¹,

Tachibana²,

Kawabata³

et al. 1999

J Geriatr Psychiatry Neurol

View full text Add to dashboard Cite

To investigate clinicoanatomic correlations of higher brain dysfunctions in corticobasal degeneration, regional cerebral blood flow (rCBF) was semiquantitatively measured with single-photon emission computed tomography in 9 patients with corticobasal degeneration and 12 age-matched control subjects. The patients showed significant reductions of relative tracer uptake in widespread cortical areas, as well as the basal ganglia and thalamus. Interhemispheric difference of hypoperfusion was significant in the sensorimotor and posterior parietal cortices. Asymmetric limb apraxia and cortical sensory disturbance corresponded to either sensorimotor cortical or posterior parietal cortical hypoperfusion or both. Compared with the patients without dementia, those with dementia showed significant reductions of relative rCBF in the inferior prefrontal region in the more affected hemisphere. The unique correlation of cortical signs with regional hypoperfusion may be useful in distinguishing between corticobasal degeneration and other neurodegenerative diseases.

show abstract

Section: Discussionmentioning

confidence: 45%

Cerebral Blood Flow Correlates of Higher Brain Dysfunctions in Corticobasal Degeneration

Okuda¹,

Tachibana²,

Kawabata³

et al. 1999

J Geriatr Psychiatry Neurol

View full text Add to dashboard Cite

show abstract

“…Although their symptoms were invariably lateralised (indeed two patients were unable to use their dominant hand), they all NT not tested; * unable to perform task due to severity of limb apraxia were also impaired when using their less involved hand in the imitation of nonsense postures. The awkward, clumsy and poorly co-ordinated nature of the movements was akin to that observed in other studies of CBD and given the label melokinetic or limb kinetic apraxia [17,19,29,30]. The apraxic deficits in CBD cannot, however, be entirely attributed to a breakdown in the action production-executive system since they showed impairment on two separate tasks which did not require a manual response: the matching of gestures-to-objects and the selection component of the Novel Tools test.…”

Section: Discussionmentioning

confidence: 64%

“…Patients show profound impairment in the production of meaningless, as well as symbolic, gestures with the features previously described as melokinetic or limb kinetic apraxia [17,18,30].…”

Section: Discussionmentioning

confidence: 99%

Apraxia, mechanical problem solving and semantic knowledge

Spatt

Bak²,

Bozeat³

et al. 2002

Journal of Neurology

View full text Add to dashboard Cite

To investigate the nature of the apraxia in corticobasal degeneration (CBD) five patients with CBD and five matched controls were compared on tests of: i) meaningless and symbolic gesture production, ii) a battery of semantic tasks based on 20 everyday items (involving naming and picture-picture matching according to semantic attributes, matching gestures-to-objects, object usage from name and with the real object) and iii) a novel tool test of mechanical problem solving. All five patients showed severe impairment in the production of meaningless and symbolic gestures from command, and by imitation, and were also impaired when using real objects. Deficits were not, however, restricted to action production: four were unable to match gestures to objects and all five showed impairment in the selection and usage of novel tools in the mechanical problem solving task. Surprising was the finding of an additional semantic knowledge breakdown in three cases, two of whom were markedly anomic. The apraxia in CBD is, therefore, multifactorial. There is profound breakdown in the organisation and co-ordination of motor programming. In addition, patients show central deficits in action knowledge and mechanical problem solving, which has been linked to parietal lobe pathology. General semantic memory may also be affected in CBD in some cases and this may then contribute to impaired object usage. This combination of more than one deficit relevant for object use may explain why CBD patients are far more disabled by their dyspraxia in everyday life than any other patient group.

show abstract

“…Since in our study SM region comprised the posterior frontal and anterior parietal cortices, and PP region comprised the superior and inferior parietal lobules, our results agree with others, indicating that the SM and PP regions are most vulnerable in CBD. The most severely affected regions appear to contribute to such higher cortical dysfunctions as limb apraxia and constructional disability [21]. In our patients, in fact, limb apraxia was severer on the side contralateral to the more hypoperfused SM and PP regions.…”

Section: Discussionmentioning

confidence: 72%

“…Previous neuroimaging studies of CBD have revealed asymmetric changes in rCBF or brain metabolism in various cortical and subcortical regions [16][17][18][19][20][21]. With positron emission tomography (PET), cortical oxygen metabolism was found to be asymmetrically decreased in the posterior frontal, superior and posterior temporal, inferior parietal and occipital association cortices, and 18 Fdopa uptake was asymmetrically reduced in the caudoputamen [16].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Brain Perfusion in Corticobasal Degeneration and Alzheimer’s Disease

Okuda

Tachibana²,

Kawabata³

et al. 2001

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

To compare brain perfusion between corticobasal degeneration (CBD) and Alzheimer’s disease (AD), we measured regional cerebral blood flow (rCBF) semiquantitatively with single-photon emission computed tomography in 10 patients with CBD and 16 with AD. There was no significant difference in age or illness duration between the patients with CBD and AD. Mini-Mental State Examination scores were significantly lower in the AD patients than in the CBD patients. All CBD patients showed asymmetric akinetic-rigid syndrome and limb apraxia. Four CBD patients were demented, and 1 AD patient had parkinsonism. Compared with 12 age-matched control subjects, the average of the left and right rCBF values for the CBD patients was significantly reduced in the prefrontal, anterior cingulate (AC), medial premotor, sensorimotor (SM), posterior parietal (PP) and superior temporal (ST) cortices as well as in the basal ganglia (BG) and thalamus (Th), while the prefrontal, PP and ST cortices were significantly hypoperfused in the AD patients. In the CBD patients, rCBF was significantly less in the AC and SM cortices, and in the Th and BG, and significantly greater in the PP cortex than in the AD patients. Interhemispheric differences of rCBF in the inferior prefrontal and SM cortices were significantly greater in the CBD patients than the AD patients. It is concluded that rCBF comparison may aid in differentiating CBD from AD.

show abstract

Focal cortical hypoperfusion in corticobasal degeneration demonstrated by three-dimensional surface display with 123 I-IMP: a possible cause of apraxia

Cited by 3 publications

References 0 publications

Cerebral Blood Flow Correlates of Higher Brain Dysfunctions in Corticobasal Degeneration

Cerebral Blood Flow Correlates of Higher Brain Dysfunctions in Corticobasal Degeneration

Apraxia, mechanical problem solving and semantic knowledge

Comparison of Brain Perfusion in Corticobasal Degeneration and Alzheimer’s Disease

Contact Info

Product

Resources

About