Focal changes in nerve, muscle and connective tissue in normal and unstable human bladder

Abstract

Objective To compare and quantify, in a morphological (91), 81 (20) and 74 (38) nerves/mm2 in the three defined areas, respectively. In the neuropathic tissues study, the changes that occur in the connective tissue elements (elastin and collagen), muscle fibre diameters the nerve profile densities were 672 (249), 57 (23) and 37 (28) nerves/mm2, respectively. Fibre diameter, and nerve densities between normal, idiopathic and neuropathic bladders.elastin and collagen content and nerve density were measured in normal and unstable bladder tissue using Materials and methods Bladder tissue was obtained from 27 patients undergoing cystectomy for carcithese three defined areas. The mean (sem) fibre diameter was 6.81 (0.52) in normal bladder; in idiopathic noma, from 12 with idiopathic instability and from seven neuropathic patients who were undergoing ileobladder tissue the fibre diameters in the three areas were 6.72 (0.62), 7.06 (0.62) and 7.34 (1.15) mm, cystoplasty. A combination of histochemical and immunohistochemical techniques were used to detect respectively, and in neuropathic bladders were 6.75 (0.62), 8.24 (0.62) and 9.35 (0.62) mm, respectively. detrusor muscle, connective tissue and nerve profiles in the bladder tissue.The relative areas of elastin were 0.79 (0.70), 0.56 (0.45) and 18.3 (4.1)% for the control, normal and Results In both idiopathic and neuropathic bladder tissue the structural changes were highly punctate. From aCected areas of the neuropathic bladders, respectively, and the relative areas of collagen were 3.5 (1.3), 6.15

Structural and Functional Denervation of Human Detrusor after Spinal Cord Injury

“…The reduction was global for all tested transmitters and appeared to be a loss of both the slender fibers and varicose terminals rather than merely loss of the IR. Detrusor denervation occurs in humans with congenital neuropathic hyperreflexia (Charlton et al, 1999;German et al, 1995), idiopathic DI (Charlton et al, 1999;Mills et al, 2000), and obstructive DI (Harrison et al, 1987;Speakman et al, 1987). In some, the denervation has been reported as patchy, akin to the current findings (Charlton et al, 1999;Mills et al, 2000).…”

“…However, there is no alteration in the overall suburothelial nerve density (Smet et al, 1997). Changes in detrusor innervation occur, with reduced densities of some transmitters in hyperreflexia , idiopathic DI (Gu et al, 1983), and bladder outflow obstruction (Chapple et al, 1992), and alterations in cholinergic nerve distribution in idiopathic DI (Charlton et al, 1999;Mills et al, 2000). The morphological studies have been supported by functional experiments.…”

Mitochondrial metabolism in the rat during bladder regeneration induced by small intestinal submucosa

“…This is made possible by the elastic and contractile properties of the bladder wall, and it is the contractile function of the bladder that consumes metabolic energy, derived from ATP synthesis driven by oxidative phosphorylation. The relationship between bladder contractile or metabolic function has already been detailed [6][7][8][9][10][11][12][13][14][15]. Mitochondrial metabolism is a very good indicator of the state of any tissue, in particular muscle, the type and performance of the mitochondria varying according to the type of tissue studied [16].…”

Botulinumtoxin in der Urologie

“…Patienten typischerweise Inseln kompletter oder teilweiser Denervierungen neben Arealen normaler Struktur (Brading and Speakman, 1998;Charlton et al, 1999;Drake et al, 2000;German et al, 1995;Mills et al, 2000) (Abb. 4.3.).…”

“…4.3.). Diese teilweise oder in Gänze denervierten Areale zeigen sich durch Bindegewebe wie Kollagen und Elastin und mit stark hypertrophierten glattmuskulären Zellen durchwoben (Brading and Speakman, 1998;Charlton et al, 1999;German et al, 1995 Greenland and Brading, 1996;Levin et al, 1999).…”