Focal Brain Therapy: Transcranial Pulse Stimulation with Ultrasound in Alzheimer's Disease—A New Navigated Focal Brain Therapy (Adv. Sci. 3/2020)

Beisteiner, Roland; Matt, Eva; Fan, Christina; Baldysiak, Heike; Schönfeld, Marleen; Novak, Tabea Philippi; Amini, Ahmad; Aslan, Tuna Stefan; Reinecke, Raphael; Lehrner, Johann; Weber, Alexandra; Reime, U.; Goldenstedt, Cédric; Marlinghaus, Ernst; Hallett, Mark; Lohse-Busch, H.

doi:10.1002/advs.202070017

Cited by 4 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Functional MRI (fMRI) also showed significantly increased connectivity within the memory network ( 28). Beisteiner's study also found that participants' depressive symptoms were significantly improved as measured by Geriatric Depression Scale (GDS) (p = 0.005) and Beck Depression Inventory (BDI) (p < 0.0001) at 1-and 3-months post-stimulation follow-up compared with the baseline scores (28). Increased connectivity in memory network was also evident in Beisteiner's study (60) in the 3months post-stimulation follow-up.…”

Section: Previous Study By the Research Teammentioning

confidence: 81%

“…The recent development of a new NIBS called "transcranial pulse stimulation" (TPS) has been proven effective for only a 2-week treatment of 35 patients with Alzheimer's disease (AD). Patients' memories had shown improvement which lasted up to 3 months (28). However, there is a paucity of scientific evidence on the efficacy of this TPS intervention on other vulnerable psychiatric populations such as MDD, which is increasingly prevalent in Hong Kong and nationwide, especially during the COVID-19 pandemic (1,2,12,29).…”

Section: Non-invasive Treatment In Psychiatrymentioning

confidence: 99%

See 1 more Smart Citation

Effects of Transcranial Pulse Stimulation (TPS) on Young Adults With Symptom of Depression: A Pilot Randomised Controlled Trial Protocol

Cheung

Yeung

et al. 2022

Front. Neurol.

Self Cite

View full text Add to dashboard Cite

BackgroundSince the emergence of the COVID-19 pandemic, there have been lots of published work examining the association between COVID-19 and mental health, particularly, anxiety and depression in the general populations and disease subpopulations globally. Depression is a debilitating disorder affecting individuals' level of bio-psychological-social functioning across different age groups. Since almost all studies were cross-sectional studies, there seems to be a lack of robust, large-scale, and technological-based interventional studies to restore the general public's optimal psychosocial wellbeing amidst the COVID-19 pandemic. Transcranial pulse stimulation (TPS) is a relatively new non-intrusive brain stimulation (NIBS) technology, and only a paucity of studies was conducted related to the TPS treatment on older adults with mild neurocognitive disorders. However, there is by far no study conducted on young adults with major depressive disorder nationwide. This gives us the impetus to execute the first nationwide study evaluating the efficacy of TPS on the treatment of depression among young adults in Hong Kong.MethodsThis study proposes a two-armed single-blinded randomised controlled trial including TPS as an intervention group and a waitlist control group. Both groups will be measured at baseline (T1), immediately after the intervention (T2), and at the 3- month follow-up (T3).RecruitmentA total of 30 community-dwelling subjects who are aged 18 and above and diagnosed with major depressive disorder (MDD) will be recruited in this study. All subjects will be computer randomised into either the intervention group or the waitlist control group, balanced by gender and age on a 1:1 ratio.InterventionAll subjects in each group will have to undertake functional MRI (fMRI) before and after six 30-min TPS sessions, which will be completed in 2 weeks' time.OutcomesBaseline measurements and post-TPS evaluation of the psychological outcomes (i.e., depression, cognition, anhedonia, and instrumental activities of daily living) will also be conducted on all participants. A 3-month follow-up period will be usedto assess the long-term sustainability of the TPS intervention. For statistical analysis, ANOVA with repeated measures will be used to analyse data. Missing data were managed by multiple mutations. The level of significance will be set to p < 0.05.Significance of the StudyResults of this study will be used to inform health policy to determine whether TPS could be considered as a top treatment option for MDD.Clinical Trial RegistrationClinicalTrials.gov, identifier: NCT05006365.

show abstract

Section: Previous Study By the Research Teammentioning

confidence: 81%

Section: Non-invasive Treatment In Psychiatrymentioning

confidence: 99%

Effects of Transcranial Pulse Stimulation (TPS) on Young Adults With Symptom of Depression: A Pilot Randomised Controlled Trial Protocol

Cheung

Yeung

et al. 2022

Front. Neurol.

Self Cite

View full text Add to dashboard Cite

show abstract

Demenzen

Onur,

Fink

2024

Therapie-Handbuch - Neurologie

View full text Add to dashboard Cite

Low-Intensity Focused Ultrasound Neuromodulation for Stroke Recovery: A Novel Deep Brain Stimulation Approach for Neurorehabilitation?

Yüksel

Sun

Latchoumane

et al. 2023

IEEE Open J. Eng. Med. Biol.

View full text Add to dashboard Cite

Stroke as the leading cause of adult long-term disability and has a significant impact on patients, society and socio-economics. Non-invasive brain stimulation (NIBS) approaches such as transcranial magnetic stimulation (TMS) or transcranial electrical stimulation (tES) are considered as potential therapeutic options to enhance functional reorganization and augment the effects of neurorehabilitation. However, non-invasive electrical and magnetic stimulation paradigms are limited by their depth focality trade-off function that does not allow to target deep key brain structures critically important for recovery processes. Transcranial ultrasound stimulation (TUS) is an emerging approach for non-invasive deep brain neuromodulation. Using non-ionizing, ultrasonic waves with millimeter-accuracy spatial resolution, excellent steering capacity and long penetration depth, TUS has the potential to serve as a novel non-invasive deep brain stimulation method to establish unprecedented neuromodulation and novel neurorehabilitation protocols. The purpose of the present review is to provide an overview on the current knowledge about the neuromodulatory effects of TUS while discussing the potential of TUS in the field of stroke recovery, with respect to existing NIBS methods. We will address and discuss critically crucial open questions and remaining challenges that need to be addressed before establishing TUS as a new clinical neurorehabilitation approach for motor stroke recovery.

show abstract

Focal Brain Therapy: Transcranial Pulse Stimulation with Ultrasound in Alzheimer's Disease—A New Navigated Focal Brain Therapy (Adv. Sci. 3/2020)

Cited by 4 publications

References 0 publications

Effects of Transcranial Pulse Stimulation (TPS) on Young Adults With Symptom of Depression: A Pilot Randomised Controlled Trial Protocol

Effects of Transcranial Pulse Stimulation (TPS) on Young Adults With Symptom of Depression: A Pilot Randomised Controlled Trial Protocol

Demenzen

Low-Intensity Focused Ultrasound Neuromodulation for Stroke Recovery: A Novel Deep Brain Stimulation Approach for Neurorehabilitation?

Contact Info

Product

Resources

About