Focal brain cooling terminates the faster frequency components of epileptic discharges induced by penicillin G in anesthetized rats

Kida, Hirotaka; Fujii, Masami; Inoue, Takao; He, Yeting; Maruta, Yuichi; Nomura, Sadahiro; Taniguchi, Koichi; Ichikawa, Takuya; Saito, Takashi; Yamakawa, Takeshi; Suzuki, Michiyasu

doi:10.1016/j.clinph.2012.02.074

Cited by 34 publications

(28 citation statements)

References 30 publications

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“…In 1998, Sartorius and Berger [9] found that hypothermia suppressed local seizures in the cerebral cortex of 22 patients who received low-temperature Green's solution intraoperatively. The finding was supported by subsequent studies [10][11][12]. In 2006, Schmitt et al [13] established that electrical stimulation ignited spontaneous SE in a rat model, and they used low temperature (the lowest temperature limit of 29 C), diazepam and joint treatment to study the effect of low temperature treatment on SE.…”

Section: Historical Evolutionmentioning

confidence: 65%

Potential mechanisms and clinical applications of mild hypothermia and electroconvulsive therapy on refractory status epilepticus

Yang

Wang²

2014

Expert Review of Neurotherapeutics

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Status epilepticus (SE) is an acute and severe neurological disorder. A small number of SE cases cannot be terminated by a sufficient therapeutic dose and duration of two to three common anticonvulsant therapies. The continuing seizures often lead to poor prognosis and a higher mortality rate. Novel non-drug treatment options to terminate SE are greatly needed. Induced hypothermia and electroconvulsive therapies are used to treat SE. There are many case studies and multiple experimental investigations of these methods in the literature. This article reviews the historical evolution, mechanisms, clinical applications and adverse reactions of SE, some of which have shown that both treatments are beneficial and relatively safe. The purpose of this paper is to provide alternative treatment methods for SE.

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Section: Historical Evolutionmentioning

confidence: 65%

Potential mechanisms and clinical applications of mild hypothermia and electroconvulsive therapy on refractory status epilepticus

Yang

Wang²

2014

Expert Review of Neurotherapeutics

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“…Termination of EDs by FBC was achieved previously in a rat model at 20°C 2,23 and at 15°C. 1,4 Power spectrum analysis of ECoG 24 indicates that cooling to 20°C and 15°C suppresses the faster (alpha and beta) ECoG band and both the faster and the slower (theta and delta) bands. In the present study, both bands were suppressed by 15°C cooling in all patients.…”

Section: Mechanism Of Seizure Suppression By Coolingmentioning

confidence: 99%

Changes in glutamate concentration, glucose metabolism, and cerebral blood flow during focal brain cooling of the epileptogenic cortex in humans

et al. 2014

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SUMMARYObjective: Recently, focal brain cooling (FBC) was proposed as a method for treating refractory epilepsy. However, the precise influence of cooling on the molecular basis of epilepsy has not been elucidated. Thus the aim of this study was to assess the effect of FBC on glutamate (Glu) concentration, cerebral blood flow (CBF), and glucose metabolism in patients with intractable epilepsy. Methods: Nine patients underwent FBC at 15°C for 30 min prior to cortical resection (n = 6) or hippocampectomy (n = 3). Measurement of metabolites and CBF, as well as electrocorticography (ECoG), was performed. Results: Epileptic discharge (ED), as observed by ECoG, disappeared in the cooling period and reappeared in the rewarming period. Glu concentrations were high during the precooling period and were reduced to 51.2% during the cooling period (p = 0.025). Glycerol levels showed a similar decrease (p = 0.028). Lactate concentration was high during the precooling period and was reduced during the cooling period (21.3% decrease; p = 0.005). Glucose and pyruvate levels were maintained throughout the procedure. Changes in CBF were parallel to those observed by ECoG. Significance: FBC reduced EDs and concentrations of Glu and glycerol. This demonstrates the neuroprotective effect of FBC. Our findings confirm that FBC is a reasonable and optimal treatment option for patients with intractable epilepsy.

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“…A device made of a thermoelectric chip based on a silver plate has been used in rats with focal seizures induced by cortical application of penicillin G or cobalt powder (Fujii et al., ; Kida et al., ). Cooling cortex focally to 10–20°C resulted in significant seizure control, but functional sensorimotor deterioration at 15°C suggests this temperature as the safety cutoff point.…”

Section: Hypothermia In Animal Models Of Epilepsymentioning

confidence: 99%

Therapeutic brain hypothermia, its mechanisms of action, and its prospects as a treatment for epilepsy

2013

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SUMMARYCooling the core body temperature to 32-35°C, is almost standard practice for conditions such as cardiac arrest in adults, and perinatal hypoxic ischemic encephalopathy in neonates. Limited clinical data, and more extensive animal experiments, indicate that hypothermia could help control seizures, and could be applied directly to the brain using implantable devices. These data have fostered further research to evaluate whether cooling would be a viable means to treat refractory epilepsy.Although the effect of temperature on cellular physiology has long been recognized, with possibly dual effects on pyramidal cells and interneurons, the exact mechanisms underlying its beneficial effects, in particular in epilepsy, are yet to be discovered. This article reviews currently available clinical and laboratory data with a focus on cellular mechanisms of action and prospects of hypothermia as a treatment for intractable seizures.

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Focal brain cooling terminates the faster frequency components of epileptic discharges induced by penicillin G in anesthetized rats

Cited by 34 publications

References 30 publications

Potential mechanisms and clinical applications of mild hypothermia and electroconvulsive therapy on refractory status epilepticus

Potential mechanisms and clinical applications of mild hypothermia and electroconvulsive therapy on refractory status epilepticus

Changes in glutamate concentration, glucose metabolism, and cerebral blood flow during focal brain cooling of the epileptogenic cortex in humans

Therapeutic brain hypothermia, its mechanisms of action, and its prospects as a treatment for epilepsy

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