Retinal vascular disorders are commonly found in ophthalmologic practice: in addition to hypertensive changes and retinal vein occlusions, diabetic eye disease plays a major role. Driven by demographic change and the obesity trend, the prevalence of diabetes has increased steadily recently and is likely to rise further. Diabetic retinopathy (DR) and diabetic macular edema (DME) are ocular complications of diabetes, where numbers are expected to double by 2030.1 As opposed to other retinal diseases, DR and DME frequently affect the working-age population, requiring long-term disease management. To date, DR and especially its manifestation DME is the main cause of severe visual impairment and blindness. [1][2][3][4] For many years, laser photocoagulation has been the mainstay in the treatment of proliferative DR (PDR) and DME. 5,6 For PDR panretinal laser photocoagulation (PRP) is the method of choice to repress neovascularization caused by retinal ischemia and to prevent serious complications. Likewise, for DME without foveal involvement focal laser has been the gold standard for the last 3 decades. 6,7 The concept of clinically significant macular edema (CSMO) was introduced by the Early Treatment Diabetic Retinopathy Study (ETDRS), describing a thickening of the retina and/or hard exudates within a distance of 500 µm from the fovea or a zone of edema greater than one disk area at a distance of one disk diameter of the fovea. 6 Even though the patient still has good vision, immediate action is warranted. Numerous studies have shown that a significant stabilization of visual acuity can be achieved in patients with CSMO by a single or repeated focal laser treatment. 3,4,7 While the exact mechanisms of action of laser photocoagulation in DME (focal or modified grid laser photocoagulation) are not fully understood, it seems clear that extensive tissue scarring is not the primary aim as it is in laser retinopexy or panretinal laser treatment for PDR. It has been postulated that a major goal of macular laser therapy is to solve leakage arising from macular vessels by photocoagulating photoreceptors and it is believed that, in macular laser treatment, photocoagulation of photoreceptor outer segments results in sealing of the blood vessels in the area of highest visual acuity and the subsequent reduced oxygen demand of the outer retina helps reduce retinal hypoxia. [8][9][10] In addition, increased oxygen tension in the inner retina helps to decrease tissue edema and improve vision by autoregulatory vasoconstriction and reduced hydrostatic pressure in the capillaries and venules. 8,10 With a delayed onset-of-action, treatment success after macular laser photocoagulation can be assessed at the earliest 3 months after the therapy session.11 Three to four treatments are typically required when using a slitlamp-based, manually applied laser to achieve stabilization of vision.11 On average, only limited visual gains can be expected. 6 Over the years, the original ETDRS laser protocol was steadily adjusted and improved, leadi...