Focal adhesion kinase inhibition decreases cell viability and induces apoptosis of JAK2 V617F positive cells
Ana Carolina Menezes Mendonça Valente,
Gustavo Henrique Lima de Farias,
Ana Cristina Ribeiro Bernardo
et al.
Abstract:Focal Adhesion Kinase (FAK) protein participates in proliferation, migration, cell survival, and apoptosis process. It has been described as overexpressed in several neoplasms being a promising target for therapy. BCR-ABL negative chronic Myeloproliferative Neoplasms (MPN) are clonal disorders characterized by the excess of proliferation and apoptosis resistance. The identification of the acquired JAK2 V617F mutation in MPN patients allowed a better understanding of pathogenesis. However, there is still no pha… Show more
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