Foamy cell mesothelioma

Cavazza, Alberto; Pasquinelli, Gianandrea; Agostini, Lidiane Pignaton; Ko, Leslie; Colby, T V

doi:10.1046/j.1365-2559.2002.14044.x

Cited by 17 publications

(13 citation statements)

References 13 publications

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“…However, the presence of lipid accumulation in carcinoma cells has not been demonstrated thus far. Several cases of mesothelioma with a foamy cytoplasm have been reported [12][13][14][15][16][17] , and intracytoplasmic lipid accumulation was reported in 2 cases [12,14] . In addition, in a case of papillary mesothelioma of the peritoneum [14] , cytoplasmic vacuoles containing lipid droplets were located in the basal portion of tumour cells that showed papillary growth.…”

Section: Discussionmentioning

confidence: 99%

Cytoplasmic Lipid Accumulation Characteristic of the Cribriform Variant of Papillary Thyroid Carcinoma

Takada¹,

Hirokawa²,

Ito³

et al. 2017

Pathobiology

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Objective: The purpose of this study was to clarify the diagnostic significance of cytoplasmic lipid accumulation (CLIA) in the cribriform variant of papillary thyroid carcinoma (CV-PTC). Methods: We performed a histological, immunohistochemical, and cytological examination of 35 CV-PTC cases at the Kuma Hospital. CLIA was defined as bubble-like multivacuolation in cytoplasm with distinct cell border. We also examined 100 conventional PTC (con-PTC) cases as controls. Results: Histological analysis showed the presence of carcinoma cells with CLIA in 60.0% of CV-PTC and 5.0% of con-PTC cases. The vacuoles tended to distribute in the subnuclear portion of carcinoma cells showing papillary growth. They were positive for oil red O staining and adipophilin. The carcinoma cells without the vacuoles showed a subnuclear dot-like expression for adipophilin in CV-PTC cases, but not in the con-PTC cases. Cytological analysis showed CLIA in 17 (54.8%) of the 31 CV-PTC cases, but not in the con-PTC cases. Conclusion: This is the first study to report the presence of carcinoma cells with CLIA in CV-PTC. The subnuclear dot-like expression of adipophilin may be characteristic of CV-PTC. These findings might be related to degenerative changes occurring in CV-PTC.

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Section: Discussionmentioning

confidence: 99%

Cytoplasmic Lipid Accumulation Characteristic of the Cribriform Variant of Papillary Thyroid Carcinoma

Takada¹,

Hirokawa²,

Ito³

et al. 2017

Pathobiology

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“…Mesotheliomas with clear cell morphology are uncommon and only a few cases have been reported under a variety of descriptive terms, including clear cell mesothelioma [9,24], glycogen-rich mesothelioma [23], lipid-rich mesothelioma [7], and foamy cell mesothelioma [6]. In the present case, the cytoplasmic clearing was caused by the accumulation of large amounts of glycogen, but this change has also been attributed to other factors, such as the presence of large amounts of lipid [7], or numerous cytoplasmic vesicles [24].…”

Section: Discussionmentioning

confidence: 99%

“…Although epithelioid mesotheliomas more often present a tubulopapillary or solid pattern, on occasion, they may present other unusual histologic patterns, including adenomatoid, deciduoid, small cell, signet ring, rhabdoid, and pleomorphic. Mesotheliomas presenting a clear cell morphology are rare and only a few individual case reports have been published [6,9,24]. The purpose of this article is to report a case of a clear cell mesothelioma that was unusual in that it originated in the peritoneum and presented as an incarcerated ventral abdominal hernia.…”

Section: Introductionmentioning

confidence: 99%

Clear cell mesothelioma presenting as an incarcerated abdominal hernia

Ordóñez

2005

Virchows Arch

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A clear cell mesothelioma presenting as an incarcerated ventral abdominal hernia in a 67-year-old man who had no history of asbestos exposure is described. The cause of the cytoplasmic clearing was the presence of large amounts of glycogen. Although uncommon, this variant of mesothelioma is important to recognize because it can be easily confused with other clear cell tumors involving the serosal membranes. Significant recent advances in the immunohistochemistry of epithelioid mesothelioma are briefly reviewed because immunohistochemical studies can be helpful in establishing the correct diagnosis.

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“…The epithelioid forms include solid epithelioid areas, squamoid solid areas, stranding, complex lace-like network, papillae, cotyledonous structures, deciduoid cells, glomeruloid features, insular features, macrocysts, microcysts, jelly rolllike structures, lymphohistiocytoid forms, tubuloglandular structures, small cells, clear cells, foam cells, and rhabdoid cells [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]. Transitions between these epithelioid forms generally occur.…”

Section: Introductionmentioning

confidence: 99%

Lymphangiomatoid pattern in diffuse malignant mesothelioma of the pleura: a report of six cases

Ruangchira-urai

Mark

2009

Virchows Arch

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The multiplicity of epithelioid and mesenchymal forms of diffuse malignant mesothelioma includes patterns that may mimic another process. Identification of the multiplicity of patterns may help in the diagnosis of diffuse malignant mesothelioma. One pattern that has not been described is lymphangiomatoid. We observed six cases with ovoid or elongated or irregular anastomosing vascular-like spaces lined by flattened cells simulating lymphangioma. The luminal spaces could contain proteinaceous material simulating lymph but not erythrocytes. The cells lining the spaces were mesothelial by immunohistochemical staining. The lymphangiomatoid areas never constituted more than 40% of the area of the tumor on the slides. When seen in more solid areas of tumor, the lymphangiomatoid structures generally did not produce diagnostic difficulty. However, when seen at the edge of solid tumor or forming an irregular nodule or invading into adjacent adipose tissue, these lymphangiomatoid structures could be confusing. All six patients had been exposed to asbestos either by occupation or by spousal exposure. Three patients received chemotherapy. One patient died of diffuse malignant mesothelioma of the pleura.

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Foamy cell mesothelioma

Cited by 17 publications

References 13 publications

Cytoplasmic Lipid Accumulation Characteristic of the Cribriform Variant of Papillary Thyroid Carcinoma

Cytoplasmic Lipid Accumulation Characteristic of the Cribriform Variant of Papillary Thyroid Carcinoma

Clear cell mesothelioma presenting as an incarcerated abdominal hernia

Lymphangiomatoid pattern in diffuse malignant mesothelioma of the pleura: a report of six cases

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