Foams for pharmaceutical and cosmetic application

Arzhavitina, A.; Steckel, Hartwig

doi:10.1016/j.ijpharm.2010.04.028

Cited by 136 publications

(108 citation statements)

References 38 publications

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“…Everyday experiences include beer, cappuccino, ice cream, shaving foams etc. Foams become now more and more popular formulations in pharmacy and cosmetics owing to their good spreadability, luck of stickiness upon application, quick absorption of active components, ease of application to hair-bearing skin and to the desired place only (foams do not easily flow unlike usual liquids of low viscosity) [3][4][5]. According to [3], patients demonstrated preference for foams in topical drug formulations.…”

Section: Introductionmentioning

confidence: 99%

Bulk and surface rheology of Aculyn™ 22 and Aculyn™ 33 polymeric solutions and kinetics of foam drainage

Bureiko

Trybała

Huang

et al. 2013

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Citation: BUREIKO, A., 2013 AbstractExperimental investigations of both bulk and surface rheology of solutions of commercially available polymers Aculyn TM 22 and Aculyn TM 33 in presence of sodium chloride are performed in a wide range of the polymer and salt concentrations. It is shown that the bulk viscosity and the surface viscoelastic modulus of solutions of both polymers increases with the increase of polymer concentration and the decrease of the salt concentration. Solutions of both polymers demonstrate very good foamability and form stable foams. Foam drainage is governed mainly by the bulk viscosity when the latter is in the range of 100-500 mPa·s.

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Section: Introductionmentioning

confidence: 99%

Bulk and surface rheology of Aculyn™ 22 and Aculyn™ 33 polymeric solutions and kinetics of foam drainage

Bureiko

Trybała

Huang

et al. 2013

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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“…Foams are widely used in food, pharmacy, personal care products, flotation and other separation processes, firefighting, petroleum and gas industries [1][2][3]. They pop up in lightweight mechanical materials and affect absorbing components in cars, heat exchangers and textured wallpapers.…”

Section: Introductionmentioning

confidence: 99%

Foams built up by non-Newtonian polymeric solutions: Free drainage

Arjmandi-Tash

Trybała

Mahdi

et al. 2017

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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A mathematical model of free drainage of foam built up by a power-law non-Newtonian liquid is developed. The theory predictions are compared with the experimental data on the drainage of foams formed using commercially available AculynTM22 and AculynTM33 polymeric solutions. The rheological parameters of the polymeric solutions were independently measured and used in the calculations. The deduced dimensionless equations were solved using finite element method with appropriate boundary conditions. The numerical simulations show that the decrease in the foam height and liquid content is very fast in the very beginning of the drainage; however, it reaches a steady state at longer time. The predicted values of the time evolution of the foam height and liquid content are in good agreement with the measured experimental data. were solved using finite element method with appropriate boundary conditions. The numerical simulations show that the decrease in the foam height and liquid content is very fast in the very beginning of the drainage; however, it reaches a steady state at longer time. Graphical AbstractThe predicted values of the time evolution of the foam height and liquid content are in good agreement with the measured experimental data.

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“…These foams are essentially gas-in-liquid dispersions, in which the gas volume fraction usually ranges between 0.5 and 0.9. They are thermodynamically and mechanically unstable systems [7]. Interestingly, foams have been shown to be generally preferred by patients over more conventional gels, creams and ointments.…”

Section: Introductionmentioning

confidence: 99%

Topical Oleaginous Minocycline Foam: Efficacious Delivery into Skin Layers

Tamarkin¹

2017

JAPLR

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Minocycline hydrochloride (MCH) is a broad spectrum antibiotic of the tetracycline group that is extensively used to treat skin conditions such as acne and rosacea. Unfortunately, since this antibiotic is highly prone to degradation, no minocyclinecontaining topical product is currently available on the market. In this pilot study, MCH was incorporated into a novel oleaginous foam recently developed by Foamix Pharmaceuticals, Ltd. The product, coded FMX101, was produced in drug concentrations of 1% w/w or 4% w/w. An in vitro porcine skin model was utilized to evaluate the extent of MCH penetration into the skin layers and compartments. The results indicated that topical foam administration allows MCH penetration that is sufficiently deep to treat most typical skin infections, acne and rosacea. Additional studies, using MALDI FTICR imaging and fluorescent microscopy techniques demonstrated visually the residence of MCH in the stratum corneum, the epidermis and the dermis and showed specific targeting to the pilosebaceous unit. The antibiotic foam caused virtually no trans-dermal drug absorption.

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Foams for pharmaceutical and cosmetic application

Cited by 136 publications

References 38 publications

Bulk and surface rheology of Aculyn™ 22 and Aculyn™ 33 polymeric solutions and kinetics of foam drainage

Bulk and surface rheology of Aculyn™ 22 and Aculyn™ 33 polymeric solutions and kinetics of foam drainage

Foams built up by non-Newtonian polymeric solutions: Free drainage

Topical Oleaginous Minocycline Foam: Efficacious Delivery into Skin Layers

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