Foam Drug Delivery in Dermatology

A novel foam vehicle for delivery of topical corticosteroids

“…12 It is well known that maximum drug transfer into the skin takes place when the drug is in a saturated solution at the vehicle-skin interface. 12,21 The evaporation of volatiles from the foam, which leaves behind little if any residue from the vehicle, may cause the active ingredient to concentrate at the interface, leading to the aforementioned saturation and then to supersaturation.…”

“…12 It is well known that maximum drug transfer into the skin takes place when the drug is in a saturated solution at the vehicle-skin interface. 12,21 The evaporation of volatiles from the foam, which leaves behind little if any residue from the vehicle, may cause the active ingredient to concentrate at the interface, leading to the aforementioned saturation and then to supersaturation. This supersaturation, although generally a transient condition, results in a drug delivery rate exceeding that of a saturated solution that may occur with other vehicles, further contributing to the enhanced rate of delivery seen with the new foam.…”

“…In the case of topical corticosteroids, the type of delivery vehicle or formulation of excipients can markedly affect the penetrant properties and absorption of the active agent, and thereby affect drug potency or effectiveness. 12 Vehicles for topical corticosteroids traditionally have included ointments, creams, lotions, gels, aerosol sprays, and powders. However, distinguishing between some of these vehicles can be problematic (eg, lotion vs cream, gel vs cream/lotion, and ointment vs cream) 13 ; vehicles that traditionally have been perceived as belonging to different categories are often structurally similar.…”

Bulk and surface rheology of Aculyn™ 22 and Aculyn™ 33 polymeric solutions and kinetics of foam drainage

“…Everyday experiences include beer, cappuccino, ice cream, shaving foams etc. Foams become now more and more popular formulations in pharmacy and cosmetics owing to their good spreadability, luck of stickiness upon application, quick absorption of active components, ease of application to hair-bearing skin and to the desired place only (foams do not easily flow unlike usual liquids of low viscosity) [3][4][5]. According to [3], patients demonstrated preference for foams in topical drug formulations.…”

Corticosteroids for Skin Delivery: Challenges and New Formulation Opportunities

“…They offer more convenient topical drug delivery with easy application and spreadability characteristics in comparision to other topical dosage forms [84,85].…”