FNIH-defined Sarcopenia Predicts Adverse Outcomes Among Community-Dwelling Older People in Taiwan: Results From I-Lan Longitudinal Aging Study

Tang, Ting; Hwang, An Chun; Liu, Li Kuo; Lee, Wei Ju; Chen, Liang Yu; Wu, Yi Hui; Huang, Chiou-Jye; Hung, Cheng Hao; Wang, Chi-Jane; Lin, Ming Hsien; Peng, Li Ning

doi:10.1093/gerona/glx148

Cited by 41 publications

(38 citation statements)

References 48 publications

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“…Secondly, we included relatively healthy participants because the baseline assessment was conducted in a community setting, which might be a constraint on the generalizability and applications to practice. Additionally, as the 24 month follow‐up period was relatively shorter than those in the previous studies, future studies should provide a longer follow‐up period for incident disability to clarify how the incidence of disability increases with advancing age.…”

Section: Discussionmentioning

confidence: 94%

“…The associations between sarcopenia and clinical adverse outcomes (i.e. disability, fracture, and mortality) were also varied, depending on the definition of sarcopenia and the formula for calculating muscle mass …”

Section: Introductionmentioning

confidence: 99%

“…disability, fracture, and mortality) were also varied, depending on the definition of sarcopenia and the formula for calculating muscle mass. [4][5][6] Bioelectrical impedance analysis (BIA) has become a popular non-invasive, inexpensive, and quick method to estimate body composition across different populations, particularly to assess sarcopenia in geriatrics. BIA measures whole-body impedance (Z), which is the opposition of the body to alternating current consisting of the following two components: resistance (R) and reactance (X C ), Z 2 = R 2 + X C 2 .…”

Section: Introductionmentioning

confidence: 99%

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Predictivity of bioimpedance phase angle for incident disability in older adults

Uemura

Doi

Tsutsumimoto

et al. 2019

J cachexia sarcopenia muscle

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Background Bioelectrical impedance analysis (BIA)‐derived phase angle is expected to be an efficient prognostic marker of health adverse events with aging as an alternative of muscle mass. We aimed to examine the predictive ability of phase angle for incident disability in community‐dwelling elderly and determine the optimal cut‐off values. Methods Community‐dwelling elderly aged ≥65 years (n = 4452; mean age = 71.8 ± 5.3 years, 48.3% women) without disability at baseline participated in this prospective cohort study. Phase angle and appendicular skeletal muscle mass (ASM) were examined using a multi‐frequency BIA at baseline. Other potential confounding factors (demographics, cognitive function, depressive symptoms, medications, and physical performance) were also assessed. Incident disability was monitored on the basis of long‐term care insurance certification. Results Over a follow‐up of 24 months, 4.0% (n = 174) experienced disability, with an overall incidence rate of 20.6 per 1000 person‐years. The Cox hazard regression analysis showed that phase angle, as a continuous variable, was independently associated with incident disability after adjusting the covariates [male: hazard ratios (HRs) = 0.61, 95% confidence interval (CI) = 0.37–0.98; female: HR = 0.58, 95% CI = 0.37–0.90], although body mass index adjusted ASM was not. Receiver operating characteristic analysis indicated moderate predictive abilities of phase angle for incident disability [male: area under the receiver operating characteristic curve (AUC) = 0.76, 95% CI = 0.70–0.83; female: AUC = 0.71, 95% CI = 0.65–0.76], while those of body mass index adjusted ASM were low (male: AUC = 0.59, 95% CI = 0.521–0.66; female: AUC = 0.58, 95% CI = 0.52–0.63). Multivariate Cox regression analysis showed that low phase angle categorized by cut‐off value (male, ≤4.95°; female, ≤4.35°) was independently related to increased risk of incident disability (HR = 1.95, 95% CI = 1.37–2.78). Conclusions Lower phase angle independently predicts the incident disability separately from known risk factors. BIA‐derived phase angle can be used as a valuable and simple prognostic tool to identify the elderly at risk of disability as targets of preventive treatment.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Predictivity of bioimpedance phase angle for incident disability in older adults

Uemura

Doi

Tsutsumimoto

et al. 2019

J cachexia sarcopenia muscle

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“…Sarcopenia has been described as an age-related decline in skeletal muscle mass as well as muscle function 1 and leads to serious health problems, including disability. [2][3][4] It is important for the elderly to shorten the period of having a disability and prolong the period of being healthy. 5 Thus, the modifiable risk factors were particularly focused on that likely to contribute to develop intervention from sarcopenia.…”

Section: Introductionmentioning

confidence: 99%

Association between anorexia of ageing and sarcopenia among Japanese older adults

Tsutsumimoto

Doi

Nakakubo

et al. 2020

J cachexia sarcopenia muscle

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Background Malnutrition plays an essential role in the mechanism of pathogenesis for sarcopenia. In late life, both food consumption and energy intakes decline. One of key factors for reduced energy intakes is anorexia of ageing. The aim of this study is to examine the association between anorexia of ageing and sarcopenia among community-dwelling elderly Japanese individuals. Methods This uses population-based, cross-sectional cohort study of elderly Japanese individuals. Anorexia of ageing was assessed via a simplified nutritional appetite questionnaire. Handgrip strength and walking speed were tested, and skeletal muscle mass was assessed using a bio-impedance analysis device. Subjects with sarcopenia were defined as those who met the criteria of the Asian Working Group for Sarcopenia. The association between anorexia of ageing and sarcopenia was then analysed via multiple regression analysis. Results In total, 9,496 elderly Japanese individuals were evaluated (mean age 74.1 ± 5.4 years; male, 47.0%). The prevalence of anorexia of ageing was 9.8% (n = 927) in the present study. The prevalence of sarcopenia in men was 1.

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“… 36 , 37 Recently, FNIH-defined sarcopenia criteria have been reported to predict death and adverse events from I-Lan Longitudinal Aging Study in Taiwan. 38 However, we showed that only a sarcopenia definition with height-adjusted muscle index was significantly associated with death or institutionalization, rather than FNIH sarcopenia criteria when adjusted for age and sex. This difference may be due to heterogeneities in the characteristics of the study population, outcome measures, and the duration of follow-up.…”

Section: Discussionmentioning

confidence: 64%

Comparisons of predictive values of sarcopenia with different muscle mass indices in Korean rural older adults: a longitudinal analysis of the Aging Study of PyeongChang Rural Area

Jang¹,

Lee²,

Yu³

et al. 2018

CIA

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PurposeIt is important to define lean muscle mass when diagnosing sarcopenia, but there is still controversy on the clinical implication of sarcopenia derived by height, weight, and body mass index (BMI) adjusted muscle mass indices. We aimed to evaluate the longitudinal clinical relevance of 3 sarcopenia definitions in the Korean population.Patients and methodsWe conducted comprehensive geriatric assessments for 1,379 community-dwelling older participants in the Aging Study of PyeongChang Rural Area (ASPRA) cohort and followed them up prospectively for death, institutionalization, and disability every 3 months. Sarcopenia was defined using the Asian Working Group consensus algorithm, combining grip strength, gait speed, and muscle mass.ResultsAmong 1,343 participants (mean age: 76 years, 741 women) analyzed, there were 29 deaths and 89 institutionalizations during 22.0 ± 8.3 months follow-up (mean ± SD). All three muscle indices correlated to age and sex. All sarcopenia criteria with muscle mass indices of height, weight, and body mass index (BMI) adjustment significantly predicted death or institutionalization. However, when adjusted for age and sex, only the sarcopenia criteria with muscle mass index of height adjustment were significantly associated with major adverse health outcomes.ConclusionAdjusting age and gender, the sarcopenia definition from the quintile-based muscle index of height adjustment could predict death or institutionalization in Korean community-dwelling older adults.

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FNIH-defined Sarcopenia Predicts Adverse Outcomes Among Community-Dwelling Older People in Taiwan: Results From I-Lan Longitudinal Aging Study

Abstract: Among community-dwelling older people in Taiwan, participants with FNIH-defined sarcopenia had a significantly greater risk of all-cause mortality and composite falls, emergency department visits, institutionalization, and hospitalization.

Cited by 41 publications

References 48 publications

Predictivity of bioimpedance phase angle for incident disability in older adults

Predictivity of bioimpedance phase angle for incident disability in older adults

Association between anorexia of ageing and sarcopenia among Japanese older adults

Comparisons of predictive values of sarcopenia with different muscle mass indices in Korean rural older adults: a longitudinal analysis of the Aging Study of PyeongChang Rural Area

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